A possible retinal information route to the circadian pacemaker through pretectal areas in the hagfish, Eptatretus burgeri

Ooka-Souda, Sadako; Kadota, Tetsuo; Kabasawa, Hiroshi; Takeuchi, Hisanao

doi:10.1016/0304-3940(95)11645-d

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…We then investigated the distribution of melanopsin in the retina of another cyclostome, the hagfish, which is suggested to be primarily involved in non-image-forming vision, rather than in image-forming vision [26]–[28]. Retrograde tracing clearly labeled cells in the proximal and distal regions of the inner layer, respectively (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The lamprey possesses developed eyes that underlie visual functions, including image-forming vision, whereas the hagfish eyes have no lens, are buried beneath the skin, and are primarily involved in non-image-forming vision, rather than image-forming vision [26]–[28]. We identified a single melanopsin in each of these animals, and demonstrated that they have similar light-activated functionalities.…”

Section: Introductionmentioning

confidence: 93%

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Distribution of Mammalian-Like Melanopsin in Cyclostome Retinas Exhibiting a Different Extent of Visual Functions

et al. 2014

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Mammals contain 1 melanopsin (Opn4) gene that is expressed in a subset of retinal ganglion cells to serve as a photopigment involved in non-image-forming vision such as photoentrainment of circadian rhythms. In contrast, most nonmammalian vertebrates possess multiple melanopsins that are distributed in various types of retinal cells; however, their functions remain unclear. We previously found that the lamprey has only 1 type of mammalian-like melanopsin gene, which is similar to that observed in mammals. Here we investigated the molecular properties and localization of melanopsin in the lamprey and other cyclostome hagfish retinas, which contribute to visual functions including image-forming vision and mainly to non-image-forming vision, respectively. We isolated 1 type of mammalian-like melanopsin cDNA from the eyes of each species. We showed that the recombinant lamprey melanopsin was a blue light-sensitive pigment and that both the lamprey and hagfish melanopsins caused light-dependent increases in calcium ion concentration in cultured cells in a manner that was similar to that observed for mammalian melanopsins. We observed that melanopsin was distributed in several types of retinal cells, including horizontal cells and ganglion cells, in the lamprey retina, despite the existence of only 1 melanopsin gene in the lamprey. In contrast, melanopsin was almost specifically distributed to retinal ganglion cells in the hagfish retina. Furthermore, we found that the melanopsin-expressing horizontal cells connected to the rhodopsin-containing short photoreceptor cells in the lamprey. Taken together, our findings suggest that in cyclostomes, the global distribution of melanopsin in retinal cells might not be related to the melanopsin gene number but to the extent of retinal contribution to visual function.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Distribution of Mammalian-Like Melanopsin in Cyclostome Retinas Exhibiting a Different Extent of Visual Functions

et al. 2014

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“…We suppose that CSF-contacting neurons are transforming CSF-mediated non-synaptic information taken up by their ventricular dendrites to synaptic one, thus informing hypothalamic or telencephalic centers. The circadian pacemaker of Eptatretus was localized to the preoptic nucleus [16,17]. Since deep encephalic photoreceptors of higher vertebrates are represented by CSFcontacting neurons without outer segments [7,29] a light-sensitive role for some (preoptic?)…”

Section: Acta Biologica Hungarica 54 2003mentioning

confidence: 99%

Cerebrospinal fluid contacting neurons in the reduced brain ventricular system of the atlantic hagfish,Myxine glutinosa

Chiu

Frank

Lukáts

et al. 2003

Acta Biologica Hungarica

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Cerebrospinal fluid (CSF)-contacting neurons are sensory-type cells sending ciliated dendritic process into the CSF. Some of the prosencephalic CSF-contacting neurons of higher vertebrates were postulated to be chemoreceptors detecting the chemical composition of the CSF, other cells may percieve light as "deep encephalic photoreceptors". In our earlier works, CSF-contacting neurons of the mechanoreceptor-type were described around the central canal of the hagfish spinal cord. It was supposed that perceiving the flow of the CSF they are involved in vasoregulatory mechanisms of the nervous tissue. In the present work, we examined the brain ventricular system of the Atlantic hagfish with special reference to the presence and fine structure of CSF-contacting neurons. Myxinoids have an ontogenetically reduced brain ventricular system. In the adult hagfish (Myxine glutinosa) the lumen of the lateral ventricle is closed, the third ventricle has a preoptic-, infundibular and subhabenular part that are not connected to each other. The choroid plexus is absent. The infundibular part of the third ventricle has a medial hypophyseal recess and, more caudally, a paired lateral recess. We found CSF-contacting neurons in the lower part of the third ventricle, in the preoptic and infundibular recess as well as in the lateral infundibular recesses. No CSF-contacting neurons were found in the cerebral aqueduct connecting the subhabenular recess to the fourth ventricle. There is a pineal recess and a well-developed subcommissural organ at the rostral end of the aqueduct. Extending from the caudal part of the fourth ventricle in the medulla to the caudal end of the spinal cord, the central canal has a dorsal and ventral part. Dendrites of CSF-contacting neurons are protruding into the ventral lumen. Corroborating the supposed choroid plexus-like function of the wall of the dorsal central canal, segmental vessels reach a thin area on both sides of the ependymal lining. The perikarya of the CSF-contacting neurons found in the brain ventricles are mainly bipolar and contain granular vesicles of various size. The bulb-like terminal of their ventricular dendrites bears several stereocilia and contains basal bodies as well as mitochondria. Basal bodies emit cilia of the 9+0-type. Cilia may arise from the basal body and accessory basal body as well. The axons run ependymofugally and enter--partially cross--the periventricular synaptic zones. No neurohemal terminals similar to those formed by spinal CSF-contacting neurons of higher vertebrates have been found in the hagfish. We suppose that CSF-contacting neurons transform CSF-mediated non-synaptic information taken up by their ventricular dendrites to synaptic one. A light-sensitive role for some (preoptic?) groups of CSF-contacting neurons cannot be excluded.

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The Nervous Systems of Jawless Vertebrates

Pombal

Megı́as

2017

Evolution of Nervous Systems

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A possible retinal information route to the circadian pacemaker through pretectal areas in the hagfish, Eptatretus burgeri

Cited by 5 publications

References 9 publications

Distribution of Mammalian-Like Melanopsin in Cyclostome Retinas Exhibiting a Different Extent of Visual Functions

Distribution of Mammalian-Like Melanopsin in Cyclostome Retinas Exhibiting a Different Extent of Visual Functions

Cerebrospinal fluid contacting neurons in the reduced brain ventricular system of the atlantic hagfish,Myxine glutinosa

The Nervous Systems of Jawless Vertebrates

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