A postulated role of testosterone for prevention of cisplatin gonadal toxicity

Preventive role of exogenous testosterone on cisplatin-induced gonadal toxicity: an experimental placebo-controlled prospective trial

“…As a result, germ cell division and metabolism would be slowed, and this in turn would curtail the damage by cisplatin chemotherapy (20). In mice given two cycles of cisplatin with exogenous T, we observed severe histopathological destruction of the testis with severe oligospermia in the early recovery phase (group Ib).…”