A potent genetic risk factor for restenosis

Ohishi, Mitsuru; Fujii, Kenshi; Minamino, Takazo; Higaki, Jitsuo; Kamitani, Atsushi; Rakugi, Hiromi; Zhao, Yongxiang; Mikami, Hiroshi; Miki, Tetsuro; Ogihara, Toshio

doi:10.1038/ng1293-324

Cited by 136 publications

(63 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we detected no association between the AT1R polymorphism and CVD events; however, the AGT polymorphism appeared to have an influence on the incidence of cardiovascular diseases in a Kaplan-Meier analysis. In cross-sectional studies, the ACE DD genotype has functioned as a risk factor for CVD in Japan; 10,[19][20][21][22]23 we confirmed this risk in our cohort. Subjects with the DD genotype exhibited higher tissue ACE activity and increased ACE expression in the plaque of acute coronary syndrome, observations that may explain why hypertensive patients with the DD genotype have a higher incidence of cardiovascular disease.…”

Section: Discussionsupporting

confidence: 81%

“…7,8 In 1992, the Etude Cas-Temoin de l'Infarctus du Myocarde study demonstrated that subjects with the DD genotype carry a significantly increased risk of myocardial infarction (MI). 9 We reported that subjects with the DD genotype have a higher risk of restenosis after emergency percutaneous coronary transluminal angioplasity, 10 hypertension in males 11 and stroke. 12 We also reported that subjects with the AGT TT genotype are at higher risk for lacunar infarction 13 and history of hypertension, 14 but not stroke.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients

et al. 2011

Self Cite

View full text Add to dashboard Cite

The renin-angiotensin system (RAS) adversely affects stroke and cardiovascular disease; polymorphisms in genes involved in this system are associated with cardiovascular disease. The aim of the present study was to confirm the genetic risk of these polymorphisms for stroke and cardiovascular events in a cohort study of 515 hypertensive patients in Japan (follow-up period 90.6±30.2 months). The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE), the M235T amino acid change in angiotensinogen, and the A1166C polymorphism in angiotensin II type 1 receptor were determined by TaqMan PCR. In Kaplan-Meier analyses, the ACE I/D polymorphism was a risk factor for cerebro-cardiovascular events, especially cardiovascular events (Po0.0001), and the M235T mutation was a risk factor for cardiovascular events (Po0.0105). The cumulative rates of cerebro-cardiovascular end points for the ACE polymorphism were 10.6, 16.4 and 42.2% for the II (n¼207), ID (n¼244) and DD (n¼64) genotype carriers, respectively (Po0.0001). Cox's proportional hazard models revealed that the ACE DD genotype was a risk factor for cerebro-cardiovascular and cardiovascular events (after adjusting for common risk factors), anti-hypertensive treatment and RAS inhibition (Po0.0001). Moreover, after adjustment for the common risk factors left ventricular hypertrophy and previous myocardial infarction/stroke, these phenomena were preserved. Thus, the DD genotype of ACE may be a genetic risk factor for cerebro-cardiovascular disease, especially cardiovascular events, in hypertensive patients in Japan.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 98%

Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…That the DD genotype contributes to fatal events, rather than nonfatal events or survival of MI, was supported by a subsequent report of association with parental history of fatal MI (12). Since then, other groups have reported an elevation in DD genotype frequency in 101 MI patients from Japan (13), as well as in 112 Caucasian patients with idopathic-dilated cardiomyopathy (14), 102 with ischemic-dilated cardiomyopathy (14), 25 with hypertrophic cardiomyopathy who had a strong family history of sudden cardiac death (15), and 32 Japanese patients with restenosis after emergency percutaneous transluminal angioplasty (16).…”

Section: Introductionmentioning

confidence: 99%

Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals.

Morris¹,

Zee²,

Schrader³

1994

J. Clin. Invest.

131

View full text Add to dashboard Cite

show abstract

“…(Rigat et al 1990). The D allele has been associated with growth of vascular smooth muscle at the site of coronary angioplasty (Ohishi et al 1993) and human cardiac hypertrophy in response to exercise (Montgomery et al 1997). …”

mentioning

confidence: 99%

Angiotensin‐Converting Enzyme Genotype Affects the Response of Human Skeletal Muscle to Functional Overload

Folland

Leach

Little

et al. 2000

Experimental Physiology

147

View full text Add to dashboard Cite

The response to strength training varies widely between individuals and is considerably influenced by genetic variables, which until now, have remained unidentified. The deletion (D), rather than the insertion (I), variant of the human angiotensin‐converting enzyme (ACE) genotype is an important factor in the hypertrophic response of cardiac muscle to exercise and could also be involved in skeletal muscle hypertrophy – an important factor in the response to functional overload. Subjects were 33 healthy male volunteers with no experience of strength training. We examined the effect of ACE genotype upon changes in strength of quadriceps muscles in response to 9 weeks of specific strength training (isometric or dynamic). There was a significant interaction between ACE genotype and isometric training with greater strength gains shown by subjects with the D allele (mean ± S.E.M.: II, 9.0 ± 1.7%; ID, 17.6 ± 2.2%; DD, 14.9 ± 1.3%, ANOVA, P 0.05). A consistent genotype and training interaction (ID DD II) was observed across all of the strength measures, and both types of training. ACE genotype is the first genetic factor to be identified in the response of skeletal muscle to strength training. The association of the ACE I/D polymorphism with the responses of cardiac and skeletal muscle to functional overload indicates that they may share a common mechanism. These findings suggest a novel mechanism, involving the renin‐angiotensin system, in the response of skeletal muscle to functional overload and may have implications for the management of conditions such as muscle wasting disorders, prolonged bed rest, ageing and rehabilitation, where muscle weakness may limit function.

show abstract

A potent genetic risk factor for restenosis

Cited by 136 publications

References 4 publications

Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients

Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients

Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals.

Angiotensin‐Converting Enzyme Genotype Affects the Response of Human Skeletal Muscle to Functional Overload

Contact Info

Product

Resources

About