A potent larvicidal agent against Aedes aegypti mosquito from cardanol

Abstract

Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. The isolation of cardanol is somewhat troublesome, however, in this work we describe an efficient and inexpensive method to obtain it as a pure material. The compound was used as starting material to make chemical transformation leading to saturated cardanol, epoxides and, halohydrins. These derivatives were tested for toxicity against Aedes aegypti larvae. The results showed that iodohydrins are very promising compounds for making commercial products to combat the vector mosquito larvae presenting a LC 50 of 0.0023 ppm after 72 h of exposure.

Acaricidal activity of cashew nut shell liquid associated with essential oils from Cordia verbenacea and Psidium guajava on Rhipicephalus microplus

“…Cardanol is produced by the decarboxylation of anacardic acid during CNSL heating (26). Cardanol and Cardol has known larvicidal activity against Aedes aegypti (27), but there are no studies show inactivity of these compounds on ticks.…”

Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol‑Based β-Amino Alcohol Derivatives

“…19 The key starting material cardanol epoxide 1 was attained in excellent yield (85%) by the reaction of cardanol (3-pentadecylphenol) with epichlorohydrin (obtained from glycerol) 60 in the presence of 4-dimethylaminopyridine (DMAP) under reflux conditions (Scheme 1). 9,19 After having the crucial precursor in hand, reactions with various amines with cardanol-epoxide 1 were carried out. To check our hypothesis, initially, we attempted the amination of cardanol epoxide 1 (1 mmol) with morpholine (1.5 mmol) in ethanol (1.5 mL) at room temperature as a model reaction.…”

“…Its derivatives present many biological activities such as: fungicidal, bactericidal, molluscicidal, larvicidal, anti-inflammatory, antioxidant and, towards serious disorders like cancer and obesity. [2][3][4][5][6][7][8][9] It is also described in the literature in recent years, that cardanol frameworks are involved to build phenolic resins, [10][11][12] bio-based polymers, 13 epoxy curing resins, [14][15][16] reactive diluents, Cardanol and glycerol can be starting materials to prepare β-amino alcohols which is a vital interesting class of organic intermediates due to their abundant existence in nature and they are useful in the preparation of wide range of biologically active natural and synthetic frameworks, pharmaceuticals (e.g. β-blockers), unnatural β-amino acids, pesticides and chiral auxiliaries.…”

“…Its derivatives present many biological activities such as: fungicidal, bactericidal, molluscicidal, larvicidal, anti-inflammatory, antioxidant and, towards serious disorders like cancer and obesity. [2][3][4][5][6][7][8][9] It is also described in the literature in recent years, that cardanol frameworks are involved to build phenolic resins, 10-12 bio-based polymers, 13 epoxy curing resins, 14-16 reactive diluents, 17,18 and fluorescent compounds. 19,20 Similarly, glycerol is another important renewable material used in the synthesis of higher value-added fine chemicals through green chemistry procedures in the last years.…”

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

“…For example, phenylpropanoids can be modified in a similar manner to eugenol derivatives to increase potency ( Barbosa et al, 2012 ). In some cases, larvicidal activity can be improved to the ppb level, as demonstrated in carnols from cashew nut shell liquid (11 ppm–2.3 ppb) ( Paiva et al, 2017 ). Structure-activity relationships (SAR) are important when constructing a nature-inspired active compound to be used in a final product.…”