A potential new biomarker to monitor the phosphorus balance in dry dairy cows

Cohrs, Imke; Wächter, Sophia; Hansen, Kirstin Anderson; Scheu, Theresa; Wilkens, Mirja R.; Grünberg, Walter

doi:10.1016/j.anifeedsci.2022.115281

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Literature data concerning the influence of dietary phosphorus as well as calcium content on activity of bone resorption markers in the blood serum are ambiguous. Similarly to results of the present study other experiments with pigs (Sørensen et al, 2018 b) and cows (Cohrs et al, 2022) also found that the concentration of serum CTX-I increased in animals fed low phosphorus diet (Ca concentration was stable and covered animals' requirements) compared to adequate fed. In both experiment such a response of animals was observed after just two weeks of feeding and in the study by Cohrs et al (2022) even increased when the duration of the experiment was prolonged.…”

Section: Relation Between the Phosphorus Intake And The Concentration...supporting

confidence: 90%

“…Similarly to results of the present study other experiments with pigs (Sørensen et al, 2018 b) and cows (Cohrs et al, 2022) also found that the concentration of serum CTX-I increased in animals fed low phosphorus diet (Ca concentration was stable and covered animals' requirements) compared to adequate fed. In both experiment such a response of animals was observed after just two weeks of feeding and in the study by Cohrs et al (2022) even increased when the duration of the experiment was prolonged. In turn, Gerlinger et al (2021) did not find differences for CTX-I concentration between pigs fed low, adequate and high level of dietary phosphorus regardless of whether the Ca : P ratio in the diets was constant or different.…”

Section: Relation Between the Phosphorus Intake And The Concentration...supporting

confidence: 90%

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Markers of bone turnover and biomechanical properties of the third metacarpal bone of growing pigs subjected to the different dietary phosphorus and calcium content

Sobol,

Skiba,

Kowalczyk

et al. 2024

Annals of Animal Science

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Eighteen weaned piglets were subjected to deficiency, adequate or excess of dietary phosphorus and calcium (group C-50, C and C+50, respectively) during growth from 33 to 110 day of age. However, the ratio of calcium/digestible phosphorus in all feeds was the same and consistent with the nutritional recommendation. Performance, bone growth, concentration of Osteocalcin (OC) and Carboxyterminal telopeptide of type I collagen (CTX-I), densitometry, geometry and mechanical properties of the 3rd metacarpal bone were measured. Growth rate and final body weight did not differ between C and C+50 animals, however, they grew approximately 5.9% faster and were heavier by about 4.0% than C-50 pigs. In turn, mass and length of bones were similar in C-50 and C+50 groups, however, were approximately 11% lighter and 4% shorter compared to C pigs. Serum content of OC took the following order C-50 < C < C+50 group (P<0.01). Content of CTX-I did not differ between C and C+50 animals, however were lower by 36% (P<0.01) than in the C-50 pigs. All measured geometry parameters (cortical wall thickness, cross section area and cortical index) did not differ between C and C+50 pigs and were higher than in C-50 pigs (P<0.01). Bones of C-50 pigs contained less minerals than bones of the C and C+50 pigs (5.24 g vs mean 6.14 g, P<0.01). The 3rd metacarpal bone mineral density (g/cm2) was the lowest in pigs in group C-50, higher in pigs in group C, and the highest in animals in group C+50 (0.398, 0.431 and 0.475, respectively, P<0.01). Maximum strength of bones was similar in the C and C+50 pigs, however by 13% greater (P<0.01) compared to C-50 animals. In turn, elastic strength and elastic deflection did not differ between the C and C-50 animals and were over 20% lower (P<0.01) than in the C+50 pigs. Whereas, there was no significant difference between groups in bone stiffness (mean 27.13 mm). The results of the present study proved that even a strong excess of phosphorus and calcium content in the diet for growing pigs is inadvisable and does not improve performance and bones parameters. While excessively lowering the dietary phosphorus and calcium concentration (e.g. to reduce environmental pollution) may adversely affect growth rate and bone characteristics.

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Section: Relation Between the Phosphorus Intake And The Concentration...supporting

confidence: 90%

Section: Relation Between the Phosphorus Intake And The Concentration...supporting

confidence: 90%

Markers of bone turnover and biomechanical properties of the third metacarpal bone of growing pigs subjected to the different dietary phosphorus and calcium content

Sobol,

Skiba,

Kowalczyk

et al. 2024

Annals of Animal Science

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“…The plasma CTX concentration has been demonstrated to be a useful indicator of mineral mobilization from bone. Cohrs et al, 2022). Pugaard et al (2014 showed that the levels of plasma CTX are proportional to osteoclastic activity .…”

Section: Milkmentioning

confidence: 99%

Reappraisal of the phosphorus requirement of lactating dairy cows

Keanthao¹

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Our aim was to evaluate the effects of a low or high dietary phosphorus (P) concentration during the dry period, followed by either a high or low dietary P concentration during the first 8 weeks of lactation, on plasma Ca concentrations, feed intake and lactational performance of dairy cattle. Sixty pregnant multiparous Holstein Friesian dairy cows were assigned to a randomized block design with repeated measurements and dietary treatments arranged in a 2 × 2 factorial fashion. The experimental diets contained 3.6 (Dry-HP) or 2.2 (Dry-LP) g P/kg dry matter (DM) during the dry period, and 3.8 (Lac-HP) or 2.9 (Lac-LP) g P/kg DM during 56 days after calving period. In dry cows, plasma Ca concentrations were 3.3% greater when cows were fed 2.2 instead of 3.6 g P/kg DM. The proportion of cows being hypocalcemic (plasma Ca concentrations < 2 mM) in the first week after calving was lowest with the low P diets both during the dry period and lactation. Plasma Ca concentrations in week1 to 8 after calving were affected by dietary P level in the dry period and in the lactation period, but no interaction between both was present. Feeding Dry-LP instead of Dry-HP diets resulted in 4.1% greater plasma Ca values, and feeding Lac-LP instead of Lac-HP diets resulted in 4.0% greater plasma Ca values. After calving, plasma Pi concentrations were affected by a 3-way interaction between sampling day after calving, and dietary P levels during the dry period and lactation. From d 1 to d 7 post-partum, cows fed Lac-HP had increased plasma Pi concentrations, and the rate appeared to be greater in cows fed Dry-LP vs. Dry-HP. In contrast, plasma Pi concentrations decreased from d 1 to d 7 post-partum in cows fed Lac-LP, and this decrease was at a higher rate for cows fed Dry-HP vs. Dry-LP. After d 7, plasma Pi concentrations remained rather constant at 1.5-1.6 mM when cows received Lac-HP while with Lac-LP plasma Pi concentrations reached stable levels (i.e. 1.3-1.4 mM) at d 28 after calving. Milk production, DM intake, and milk concentrations of P, Ca, fat, protein and lactose were not affected by any interaction nor the levels of dietary P. It is concluded that the feeding of diets containing 2.2 g P/kg DM during the last 6 weeks of the dry period and 2.9 g P/kg DM during early lactation increased plasma Ca levels when compared with greater dietary P levels. These low P diets may be instrumental in preventing hypocalcemia in periparturient cows and do not compromise DMI and milk production. Current results suggest that P requirements in dairy cows during dry period and early lactation can be fine-tuned towards lower values than recommended by both the NRC (2001) and the Dutch Central Bureau for Livestock Feeding (CVB, 2012). Caution, however, is warranted to extrapolate current findings to entire lactations because long term effects of feeding low P diets containing 2.9 g/kg DM on production and health needs further investigation.

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Phosphorus Metabolism During Transition

Grünberg

2023

Veterinary Clinics of North America: Food Animal Practice

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A potential new biomarker to monitor the phosphorus balance in dry dairy cows

Cited by 4 publications

References 15 publications

Markers of bone turnover and biomechanical properties of the third metacarpal bone of growing pigs subjected to the different dietary phosphorus and calcium content

Markers of bone turnover and biomechanical properties of the third metacarpal bone of growing pigs subjected to the different dietary phosphorus and calcium content

Reappraisal of the phosphorus requirement of lactating dairy cows

Phosphorus Metabolism During Transition

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