2010
DOI: 10.3109/02652048.2010.539304
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A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide

Abstract: Methazolamide (MTA) is an antiglaucoma drug; however, there are many side effects of its systemic administration with insufficient ocular therapeutic concentrations. The aim of this study was to formulate MTA-loaded solid lipid nanoparticles (SLNs) and evaluate the potential of SLNs as a new therapeutic system for glaucoma. SLNs were prepared by a modified emulsion-solvent evaporation method and their physicochemical characteristics were evaluated. The pharmacodynamics was investigated by determining the perce… Show more

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Cited by 68 publications
(30 citation statements)
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“…[108,109], as confirmed by others [106,110]. Liposomes have been studied for the delivery of acetazolamide via eye drops [111] or latanoprost via single subconjunctival injection [112,113].…”
Section: B Glaucoma Therapiesmentioning
confidence: 80%
“…[108,109], as confirmed by others [106,110]. Liposomes have been studied for the delivery of acetazolamide via eye drops [111] or latanoprost via single subconjunctival injection [112,113].…”
Section: B Glaucoma Therapiesmentioning
confidence: 80%
“…68 In other model systems, solid lipid nanoparticles containing methazolamide yield prolonged therapeutic efficacy in reducing intraocular pressure in glaucoma compared to commercial eye drop preparations. 69 Magnetic hyperthermia was used with superparamagnetic Mn 0.5 Zn 0.5 Fe 2 O 4 nanoparticles to induce heat shock proteins throughout the vitreous body as a neuroprotective strategy for glaucoma. 70 Delivery of macromolecules and plasmid DNA to the nuclei of retinal and corneal cells can be achieved using PEGylated nucleolin-binding peptide nanoparticles.…”
Section: Nanomedicines For the Diagnosis And Treatment Of Cancermentioning
confidence: 99%
“…Another approach is usage of solid lipid nanoparticles loaded with neuroprotective drugs. Researchers have reported promising results from experiments using laboratory-created nanoparticles to deliver a glaucoma medication (Li et al, 2011). Investigations into this approach for treating glaucoma were in very early stages.…”
Section: Potential Methods For Nts Deliverymentioning
confidence: 99%