A potential of terahertz solid immersion microscopy for visualizing sub-wavelength-scale tissue spheroids

Chernomyrdin, Nikita V.; Kucheryavenko, Anna S.; Kolontaeva, G. S.; Katyba, Gleb M.; Каралкин, П. А.; Parfenov, Vladislav A.; Gryadunova, A. A.; Norkin, N. E.; Smolyanskaya, O. A.; Minin, Oleg V.; Minin, Igor V.; Karasik, Valeriy E.; Zaytsev, Kirill I.

doi:10.1117/12.2306132

Cited by 21 publications

(12 citation statements)

References 58 publications

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“…Спектроскопия и визуализация в терагерцовом диапазоне могут послужить основной для перспективных инструментальных средств дифференциальной диагностики пигментных новообразований кожи, так как в настоящее время установлены особенности оптических терагерцовых характеристик различных классов новообразований [39]. Появление суперразрешающих систем визуализации в терагерцовом диапазоне на основе спектроскопического контрастирования вполне способно создать тренд в развитии диагностики опухолей малого диаметра, о чём свидетельствуют современные исследования [68,69]. Возможно, имеющиеся ограничения разрешающей способности такого оборудования, способного визуализировать структуры размерами в доли миллиметра, будут компенсированы именно высокой чувствительностью к спектральным различиям биологических тканей в норме и при патологии.…”

Section: Discussionunclassified

Ранняя Диагностика Меланомы Кожи С Применением Нескольких Изображающих Систем

Кудрин¹,

Римская²,

Аполлонова³

et al. 2020

Журнал Технической Физики

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A complex approach to the early diagnosis of skin melanoma has been proposed. The approach involves a step-by-step examination of pigment tumors using several imaging systems. The features of morphometry of clinical images of pigmented skin neoplasms, features of imaging systems, the main stages of automated image processing and pattern recognition in the melanoma diagnosis has been considered. The metrological features of the proposed approach has been shown: the measurement errors of the clinical parameters of skin neoplasms by the proposed methods do not exceed the allowable errors. The approbation of the offered approach has been showed that sensitivity and specificity of the used methods exceeds 90%

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Section: Discussionunclassified

Ранняя Диагностика Меланомы Кожи С Применением Нескольких Изображающих Систем

Кудрин¹,

Римская²,

Аполлонова³

et al. 2020

Журнал Технической Физики

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“…The focusing of light by the microspheres forms a nanojet, which transmits the converted propagating waves to the space outside the sphere, which plays an important role in enhancing the image contrast. Furthermore, Chernomyrdin et al used a method of the terahertz solid immersion microscope to focus electromagnetic waves to the evanescent field volume through a lens, thereby reducing the size of the terahertz beam caustics [141]. When articular hyaline cartilage of male sheep is placed on the scanning window of the system, the tissue ellipsoid of sub-wavelength diameter can be distinguished.…”

Section: Super-resolution Imaging Of Living Cells By Photonic Nanojetsmentioning

confidence: 99%

Optical Trapping, Sensing, and Imaging by Photonic Nanojets

Song

Zhao

et al. 2021

Photonics

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The optical trapping, sensing, and imaging of nanostructures and biological samples are research hotspots in the fields of biomedicine and nanophotonics. However, because of the diffraction limit of light, traditional optical tweezers and microscopy are difficult to use to trap and observe objects smaller than 200 nm. Near-field scanning probes, metamaterial superlenses, and photonic crystals have been designed to overcome the diffraction limit, and thus are used for nanoscale optical trapping, sensing, and imaging. Additionally, photonic nanojets that are simply generated by dielectric microspheres can break the diffraction limit and enhance optical forces, detection signals, and imaging resolution. In this review, we summarize the current types of microsphere lenses, as well as their principles and applications in nano-optical trapping, signal enhancement, and super-resolution imaging, with particular attention paid to research progress in photonic nanojets for the trapping, sensing, and imaging of biological cells and tissues.

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“…For this reason, a tremendous amount of research is dedicated to the enhancement of far-field THz imaging. In addition to digital image reconstruction techniques, [238][239][240] high-resolution THz imaging based on utilizing aperture synthesis, 241 dielectric cube terajet generation, [242][243][244][245][246] solid immersion imaging, [247][248][249][250] confocal THz laser microscope, 251 and wide-aperture spherical lens 252,253 for 3-D and flat diffractive optics 254,255 were proposed.…”

Section: Terahertz Opticsmentioning

confidence: 99%

Survey of terahertz photonics and biophotonics

et al. 2020

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We review the advances of terahertz (THz) science and technology in biophotonics, including related challenges and solutions. The main impediment to THz spectroscopy and imaging in this field is the high absorption of the THz beam in water. Hence, transmission imaging and spectroscopy of thick wet tissue using THz radiation has generally been quite difficult. However, the absorption of THz waves by water molecules is so strong that increasing the power of the THz source can lead to structural and functional changes in tissues, so solutions must go beyond a larger power output. In terms of resolution, THz imaging is superior to ultrasound but inferior to visible light microscopy. Owing to its unique material analysis capabilities, promising diagnosis applications have been demonstrated through THz imaging and spectroscopy. Unfortunately, many applications are limited by beam penetration depth and resolution. Hence, researchers from a wide variety of scientific and technical fields have been actively improving these features through the development of electronic devices and materials. In addition, groundbreaking optical architecture and materials to reduce beam absorption in the optics of a system and generate focused beams with smaller diameters have been proposed. On the software side, image processing techniques to computationally enhance the resolution and quality of THz imaging have been proposed. Data science and machine learning to automate the diagnosis of defects and diseases through processing THz images and spectroscopy data have been proposed. We have reviewed the applications of THz radiation in biophotonics and research achievements toward advancing these applications. A conclusion with a roadmap toward increasing the footprint of the THz technology in biophotonics is also proposed.

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A potential of terahertz solid immersion microscopy for visualizing sub-wavelength-scale tissue spheroids

Cited by 21 publications

References 58 publications

Ранняя Диагностика Меланомы Кожи С Применением Нескольких Изображающих Систем

Ранняя Диагностика Меланомы Кожи С Применением Нескольких Изображающих Систем

Optical Trapping, Sensing, and Imaging by Photonic Nanojets

Survey of terahertz photonics and biophotonics

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