2017
DOI: 10.21577/0103-5053.20170057
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A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties

Abstract: The cis-[Ru(bpy) 2 (4-bzpy)(NO)](PF 6 ) 3 complex was prepared (4-bzpy = 4-benzoylpyridine), and characterized by UV-visible, infrared and nuclear magnetic resonance (NMR) spectroscopies and electrochemical techniques. The reaction with cysteine was preliminarily investigated, aiming to shed light on the potential biological mechanism for NO or HNO release mediated by thiols. Furthermore, photochemical behavior of cis-[Ru(bpy) 2 (4-bzpy)(NO)](PF 6 ) 3 was studied, where it was observed NO release upon ultravio… Show more

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Cited by 6 publications
(13 citation statements)
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“…The most accepted mechanistic proposal for these processes follows the one illustrated by Franco and collaborators (Scheme 16). [120a,123,127] This mechanism describes the reaction of a nitrosyl complexes of Ru II and thiol‐based compound, which following quite similar steps as proposed in Scheme 14. A metal system [Ru(L) x (NO)] n+ (L is a ligand and x varies from 1 to 5) when attacked by an RS − group produces a first intermediate [Ru(L) x (N(O)SR)] (n−1)+ .…”
Section: Metal‐based No and Hno Donorsmentioning
confidence: 89%
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“…The most accepted mechanistic proposal for these processes follows the one illustrated by Franco and collaborators (Scheme 16). [120a,123,127] This mechanism describes the reaction of a nitrosyl complexes of Ru II and thiol‐based compound, which following quite similar steps as proposed in Scheme 14. A metal system [Ru(L) x (NO)] n+ (L is a ligand and x varies from 1 to 5) when attacked by an RS − group produces a first intermediate [Ru(L) x (N(O)SR)] (n−1)+ .…”
Section: Metal‐based No and Hno Donorsmentioning
confidence: 89%
“…On the other hand, [Ru(L) x (N(O)SR)] (n−1)+ in reaction with an excess of RS − can produce a second adduct [Ru(L) x (N(O)(SR) 2 )] (n−2)+ , a precursor of the [Ru(L) x HNO] (n−1)+ complex. This latter species has been proposed as the donor of HNO (Scheme 16B) [120a,123,127] …”
Section: Metal‐based No and Hno Donorsmentioning
confidence: 99%
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“…Com base nesses resultados, constata-se um comportamento similar entre os dois compostos estudados neste trabalho com sistemas relatados na literatura. 70,71 Atividade antibacteriana frente a Pseudomonas aeruginosa A atividade antibacteriana do nitrosilo complexo foi testada frente à bactéria de cepa gram-negativa Pseudomonas aeruginosa ATCC -9027 (Figura 6). Desse modo, foi observado que o complexo 1 (Concentração Inibitória Mínima (CIM) = 121,5 mmol L -1 ) é capaz de inibir o crescimento das bactérias Pseudomonas aeruginosa (ATCC -9027) numa concentração bem menor que o complexo 2 (CIM > 500 mmol L -1 ).…”
Section: Estudo Fotoquímicounclassified