A practical score for risk stratification of embolic stroke in hypertrophic cardiomyopathy

Thromboembolism in Patients with Hypertrophic Cardiomyopathy

“…Late gadolinium enhanced (LGE) extent > 14.4% on cardiovascular magnetic resonance (CMR) was regarded as an independent predictor for thromboembolic events in HCM patients (sensitivity 65%, specificity 78.1%, AUC 0.79, P<0.0001) 47 . A study reported CHADS 2 > 1 combined with left ventricular outflow tract gradient (LVOTG) >38 mmHg was an independent predictor of embolic stroke in HCM patients 48 . Additionally, some factors associated with AF like left ventricular outflow tract obstruction, systolic anterior movement (SAM), mitral regurgitation (MR)[49]predisposing hemodynamic might increase the thromboembolic risk.…”

Atrial Fibrillation and Anticoagulation in Hypertrophic Cardiomyopathy

“…was associated with increased risk of CVA and have advocated its use as part of a score for the incidence of CVA in the HCM popuatlion. 62 Inoue and colleagues, when assessing thromboembolic rates in those with non-valvular AF, have advocated a single point for the presence of HCM to the CHADS 2 score; 63 however, they failed to define a clear threshold at which point anticoagulation became necessary; instead assigned patients to low-, moderate-and high-risk categories. A low CHA 2 DS 2 -VASc score has been suggested as an appropriate marker for identifying little risk of thromboembolism in patients with HCM and AF.…”

Atrial Fibrillation and Anticoagulation in Hypertrophic Cardiomyopathy

“…was associated with increased risk of CVA and have advocated its use as part of a score for the incidence of CVA in the HCM popuatlion. 62 Inoue and colleagues, when assessing thromboembolic rates in those with non-valvular AF, have advocated a single point for the presence of HCM to the CHADS 2 score; 63 however, they failed to define a clear threshold at which point anticoagulation became necessary; instead assigned patients to low-, moderate-and high-risk categories. A low CHA 2 DS 2 -VASc score has been suggested as an appropriate marker for identifying little risk of thromboembolism in patients with HCM and AF.…”