A Preclinical Study on Wound Healing Activity of Lawsonia ulba Linn.

Nithya, V.; Baskar, Anusha

doi:10.3923/rjphyto.2011.123.129

Cited by 18 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in accordance with those of Mandawgade and Patil [33] who demonstrated that ethanol henna leaf extract promoted wound healing by 97%, compared to the control, in both excision and incision wound models in rats. In addition, a rapid wound contraction have been also observed in treated rats with ethanol Lawsonia ulba Lin leaf extract (71%), compared to those treated with nitrofurazone ointment (70%) and the untreated rats (58%) [34].…”

Section: Wound Closurementioning

confidence: 93%

Wound healing activity of cuttlefish gelatin gels and films enriched by henna (Lawsonia inermis) extract

Jridi

Sellimi

Lassoued

et al. 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

The in vivo wound-healing potential of gels and films based on cuttlefish skin gelatin (CSG) incorporated with aqueous henna extract (AHE) (at 50 and 500 µg/ml) was studied.Since wound healing is related to reactive oxygen species (ROS), this study was first conducted to evaluate the antioxidant activity of AHE by DPPH radical-scavenging, β-carotene-linoleate bleaching, and reducing power assays. The major volatile compounds were lawsone, dimethyl sulfoxide, dimethyl sulfide, eugenol and maltol. The finding of the study showed that the incorporation of AHE into gelatin gels and films enhanced the antioxidant activity in a dose-dependent manner. In the wound-healing study, topical application of gelatin hydrogels or films enriched by AHE, on the wound site in a rat model, enhanced significantly wound healing activity and helped to prevent from inflammation damage, when compared to the control and CICAFLORA®-treated groups. Further, all preparations were found to improve the antioxidant status of treated rats as was evidenced by increased antioxidant enzymatic activities and reduced MDA content. The increase in the activities of catalase (CAT), superoxide dismutase (SOD) and gluthatione peroxydase (GPx) in wound tissues revealed that bioactive compounds in AHE, film and gel are able to enhance the healing of wounds by reducing the damage caused by ROS. Wound-healing activity was confirmed by histopathology studies. The obtained results showed that the addition of AHE to the gelatin matrix could improve the wound healing activity.

show abstract

Section: Wound Closurementioning

confidence: 93%

Wound healing activity of cuttlefish gelatin gels and films enriched by henna (Lawsonia inermis) extract

Jridi

Sellimi

Lassoued

et al. 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

show abstract

“…Plants are more potent healers because they promote the repair mechanisms in the natural way. The healing process can be physically monitored by assessing the rate of contraction of the wound [10]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant and Wound Healing Potentials ofSphaeranthus amaranthoidesBurm.f.

Geethalakshmi

Sakravarthi

Kritika

et al. 2013

BioMed Research International

View full text Add to dashboard Cite

Background. Sphaeranthus amaranthoides commonly known as sivakaranthai is used in folklore medicine for the treatment of skin diseases. Methods. The antioxidant activity of the extract and its fraction was evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, total antioxidant capacity, and total phenolic content. The tested plant extracts showed variable degrees of antioxidant activity. In the present study, methanolic extract of the whole plant of S. amaranthoides and a flavonoid fraction obtained from column chromatography were studied for wound healing activity by incorporating the sample in simple ointment base. Wound healing activity was studied in excision wound model in rats, following which, wound contraction, period of epithelization, hydroxyproline content, and collagen levels in the scab were studied. Results. Methanolic extract showed the highest antioxidant effect (72.05%) and diethyl ether extract has the least (29.34%) compared to the standard (74.53%). Treatment of wound with ointment containing 5% (w/w) methanolic extract and 5% (w/w) flavonoid fraction exhibited better wound healing activity than positive control (silver sulfadiazine). Finally, histopathology studies conformed wound healing activity in Sphaeranthus amaranthoides. The methanolic extract and flavonoid fraction exhibited good wound healing activity probably due to the presence of phenolic and flavonoid constituents. The methanolic extract and flavonoid fraction significantly enhanced the rate of wound contraction and the period of epithelialization comparable to silver sulfadiazine.

show abstract

“…Phenolic compounds have been documented to possess potent antioxidant and free radical scavenging effect, which is believed to be one of the most important components of wound healing. Sulfur containing compounds are also important in healing accelerated efficacy and antimicrobial potency [ 34 ]. The extract has been reported to have a broad spectrum antibacterial activity in this study, which also seemed to have beneficial effects on promoting wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Two types of ointment formulations were prepared from the extract. Five percent ( w /w) and 10% ( w /w), where 5 or 10 g of the extract were incorporated in to 100 g of simple ointment base respectively [ 33 , 34 ]. Nitrofurazone ointment (0.2% w /w) was used as a standard drug for comparing the wound healing potential of the extract [ 31 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Methanol leaves extract Hibiscus micranthus Linn exhibited antibacterial and wound healing activities

Begashaw

Mishra

Tsegaw

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundInfectious diseases are the most common causes of morbidity and mortality in developing countries. Wound and wound infections are also major health problem. Nowadays, medicinal plants play a major role in treatment of infectious diseases and wound healing and they are easily available and more affordable as compared to synthetic compounds. The aim of this study is therefore, to investigate the antibacterial and wound healing activities of 80% methanol extract of Hibiscus micranthus leaves using disc diffusion methods and rat excision model respectively.MethodsIn vitro antibacterial screening was carried out against S. aureus, S.pneumoniae, S. pyogenes, E. coli, P. aeruginosa, K. pneumoniae and P. mirabilis bacterial strains using disc-well diffusion assay. Would healing activity was done in rats divided into four groups each consisting of six animals. Group I was served as a negative control (ointment base), Group II served as a positive control Nitrofurazone (NFZ 0.2% ointment), Groups III and IV was treated 5 and 10% extracts respectively. The acute oral toxicity test and skin sensitivity test were also performed before conducting the actual study. The extract was analyzed for secondary metabolites using standard methods.ResultsPreliminary phytochemical screening have revealed the presence of alkaloids, flavonoids, saponins, tannins, steroids, phenols, diterpines, anthraquinones and the absence of glycosides, terpinoides and triterpines. Based on acute oral toxicity test the extract was found to be safe up to a dose of 2 g/kg. In addition, acute dermal toxicity test indicated no sign of skin irritation. The leaves extract exhibited varying degrees of sensitivity with zones of inhibition ranging from 14.00 ± 0.333 (S.pyogenes) to 22.67 ± 1.202 mm (S.aureus). It was found that S. aureus and S. pneumonia (p < 0.05) were the most sensitive to the extracts of the leaves at concentrations of 800 μg/ml and 400 μg/ml respectively followed by P. aeuruginosa [(18.33 ± .333 mm) (p < 0.05)] at a concentration of 400 μg/ml. However, E. coli and P. mirabilis were found to be resistant to the extract at any of the applied doses. In the wound healing study, the 5 and 10% w/w extract exhibited significant wound contraction rate of 99.30% and 99.13% as compared to NFZ ointment and simple ointment base treated groups from 6th to 16th day, respectively (p < 0.05).ConclusionThe present study suggests that the methanol extract of the leaves exhibited a potential antibacterial activity against the tested microorganisms and wound healing activity.

show abstract

A Preclinical Study on Wound Healing Activity of Lawsonia ulba Linn.

Cited by 18 publications

References 11 publications

Wound healing activity of cuttlefish gelatin gels and films enriched by henna (Lawsonia inermis) extract

Wound healing activity of cuttlefish gelatin gels and films enriched by henna (Lawsonia inermis) extract

Evaluation of Antioxidant and Wound Healing Potentials ofSphaeranthus amaranthoidesBurm.f.

Methanol leaves extract Hibiscus micranthus Linn exhibited antibacterial and wound healing activities

Contact Info

Product

Resources

About