A Predictable Approach of a Rare and Frequently Misdiagnosed Entity: Laryngeal Nerve Schwannoma

Filipov, Iulian; Chirilă, Lucian; Săndulescu, Mihai; Cristache, Corina Marilena

doi:10.3390/healthcare10010059

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Summarizing sonographic appearances of the schwannoma in different anatomical locations worth to note that possible US patterns are solid 6,24,25 , cystic 9,12,26 , and mixed 27,28 . Reynolds et al (2003) presented the US results more than worth of attention.…”

Section: Discussionmentioning

confidence: 99%

Schwannoma of the Tongue: Ultrasonography

Demidov

Cherniak

Snisarevskyi

et al. 2022

J. Diagn. Treat. Oral Maxillofac. Pathol.

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Schwannoma is a rare benign tumor originated from the Schwann cells of the nerve sheath. Other common names are neurilemmoma, neurinoma, and neurinoma of Verocay. The tumor is encapsulated and shows slow growth reaching even the 8.5-cm size. The purpose of this paper is to provide clinical presentation, sonogram and ultrasound video of schwannoma of the tongue, its analysis along with intraoperative and histopathological data. A 27-year-old female patient with tongue schwannoma is presented and analysis of the published schwannoma cases in different anatomical areas is performed. Distinctive sonographic features of this type of tumor are showed and comparison with the other tongue masses is highlighted. Ultrasonography proved its efficacy as a first-line diagnostic tool which needs to be popularized among oral and maxillofacial surgeons.

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Section: Discussionmentioning

confidence: 99%

Schwannoma of the Tongue: Ultrasonography

Demidov

Cherniak

Snisarevskyi

et al. 2022

J. Diagn. Treat. Oral Maxillofac. Pathol.

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“…Peripheral nerve sheath tumours (PNSTs) in the neck, including schwannomas, neurofibromas, and malignant PNSTs, consist of 40–45% of all PNSTs, and the parapharyngeal area is the most common location 1 – 3 . The reported incidence of vagus schwannoma is 2.93 per million person-years in the 65–74-year-old age group 4 . Malignant PNSTs account for 5–10% of soft tissue sarcomas with an overall incidence of 1.46 per million person-years 5 .…”

Section: Introductionmentioning

confidence: 99%

Quantification of vessel separation using the carotid-jugular angle to predict the nerve origin of neck peripheral nerve sheath tumours: a pooled analysis of cases from the literature and a single-center cohort

Wong

Huang

Chuang

et al. 2023

International Journal of Surgery

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Background: Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumours (PNSTs). Accurate preoperative identification of the nerve origin (NO) can improve surgical outcomes and patient counselling. Material and methods: This study was a retrospective cohort and quantitative analysis of the literature. The authors introduced a parameter, the carotid-jugular angle (CJA), to differentiate the NO. A literature review of neck PNST cases from 2010 to 2022 was conducted. The CJA was measured from eligible imaging data, and quantitative analysis was performed to evaluate the ability of the CJA to predict the NO. External validation was performed using a single-centre cohort from 2008 to 2021. Results: In total, 17 patients from our single-centre cohort and 88 patients from the literature were analyzed. Among them, 53, 45, and 7 patients had sympathetic, vagus, and cervical nerve PNSTs, respectively. Vagus nerve tumours had the largest CJA, followed by sympathetic tumours, whereas cervical nerve tumours had the smallest CJA (P<0.001). Multivariate logistic regression identified a larger CJA as a predictor of vagus NO (P<0.001), and receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) of 0.907 (0.831–0.951) for the CJA to predict vagus NO (P<0.001). External validation showed an AUC of 0.928 (0.727–0.988) (P<0.001). Compared with the AUC of the previously proposed qualitative method (AUC=0.764, 0.673–0.839), that of the CJA was greater (P=0.011). The cut-off value identified to predict vagus NO was greater than or equal to 100°. Receiver operating characteristic analysis showed an AUC of 0.909 (0.837–0.956) for the CJA to predict cervical NO (P<0.001), with a cut-off value less than 38.5°. Conclusions: A CJA greater than or equal to 100° predicted a vagus NO and a CJA less than 100° predicted a non-vagus NO. Moreover, a CJA less than 38.5 was associated with an increased likelihood of cervical NO.

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