A prediction model for magnetic particle imaging–based magnetic hyperthermia applied to a brain tumor model

Le, Tuan‐Anh; Hadadian, Yaser; Yoon, Jungwon

doi:10.1016/j.cmpb.2023.107546

Cited by 10 publications

(3 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the imaging methods discussed above, imaging methods include magnetic ( Son et al, 2016 ; Xu et al, 2021 ; Le et al, 2023 ) and radio frequency positioning methods ( Bao et al, 2015 ; Hoang et al, 2023 ). The spatial position information of the microrobot was obtained by collecting and processing magnetic field information/high-frequency electromagnetic waves.…”

Section: Control System Of Magnetic Medical Microrobotsmentioning

confidence: 99%

System integration of magnetic medical microrobots: from design to control

Zhou,

Li,

et al. 2023

Front. Robot. AI

View full text Add to dashboard Cite

Magnetic microrobots are ideal for medical applications owing to their deep tissue penetration, precise control, and flexible movement. After decades of development, various magnetic microrobots have been used to achieve medical functions such as targeted delivery, cell manipulation, and minimally invasive surgery. This review introduces the research status and latest progress in the design and control systems of magnetic medical microrobots from a system integration perspective and summarizes the advantages and limitations of the research to provide a reference for developers. Finally, the future development direction of magnetic medical microrobot design and control systems are discussed.

show abstract

Section: Control System Of Magnetic Medical Microrobotsmentioning

confidence: 99%

System integration of magnetic medical microrobots: from design to control

Zhou,

Li,

et al. 2023

Front. Robot. AI

View full text Add to dashboard Cite

show abstract

“…This temperature change affects the physiology of tumor cells, inducing apoptosis and/or cellular necrosis [ 15 , 16 , 17 ]. The MHT technique has its advantages as a non-invasive approach, as it is applicable to deep-seated tumors, causes the selective death of tumor cells without harming surrounding healthy tissues, and has a high heating performance compared to other heat-based therapies [ 18 , 19 ], showing its efficacy in tumor therapeutics [ 20 ]. One of the most magnetic NP used in this technique is iron oxide nanoparticles (ION), which have been used in a series of preclinical studies to treat various tumors [ 21 , 22 , 23 , 24 , 25 , 26 ], as well as BC [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training

Theinel,

Nucci,

Cianciarullo

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Breast cancer (BC) presents a growing global concern, mainly for the female population of working age. Their pathophysiology shows challenges when attempting to ensure conventional treatment efficacy without adverse effects. This study aimed to evaluate the efficacy of magneto-hyperthermia (MHT) therapy associated with supplementation with omega-3 polyunsaturated fatty acid (w-3 PUFA) and engagement in physical training (PT) for the triple-negative BC (TNBC) model. First, we assessed the physicochemical properties of iron oxide nanoparticles (ION) in biological conditions, as well as their heating potential for MHT therapy. Then, a bioluminescence (BLI) evaluation of the best tumor growth conditions in the TNBC model (the quantity of implanted cells and time), as well as the efficacy of MHT therapy (5 consecutive days) associated with the previous administration of 8 weeks of w-3 PUFA and PT, was carried out. The results showed the good stability and potential of ION for MHT using 300 Gauss and 420 kHz. In the TNBC model, adequate tumor growth was observed after 14 days of 2 × 106 cells implantation by BLI. There was a delay in tumor growth in animals that received w-3 and PT and a significant decrease associated with MHT. This pioneering combination therapy approach (MHT, omega-3, and exercise) showed a positive effect on TNBC tumor reduction and demonstrated promise for pre-clinical and clinical studies in the future.

show abstract

“…Further advances integrated MPI with an AMF heater and used the MPI gradient field to restrict heating to a particular area within the AMF coil [ 25 , 26 ]. One group developed a computational model for predicting the spatio-thermal resolution of combined MPI/MPH systems [ 27 ]. A fully automated prototype AMF heating platform that enables spatially confined heating in a user-selected region of interest has also been described [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Particle Imaging-Guided Thermal Simulations for Magnetic Particle Hyperthermia

Carlton,

Arepally,

Healy

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Magnetic particle hyperthermia (MPH) enables the direct heating of solid tumors with alternating magnetic fields (AMFs). One challenge with MPH is the unknown particle distribution in tissue after injection. Magnetic particle imaging (MPI) can measure the nanoparticle content and distribution in tissue after delivery. The objective of this study was to develop a clinically translatable protocol that incorporates MPI data into finite element calculations for simulating tissue temperatures during MPH. To verify the protocol, we conducted MPH experiments in tumor-bearing mouse cadavers. Five 8–10-week-old female BALB/c mice bearing subcutaneous 4T1 tumors were anesthetized and received intratumor injections of Synomag®-S90 nanoparticles. Immediately following injection, the mice were euthanized and imaged, and the tumors were heated with an AMF. We used the Mimics Innovation Suite to create a 3D mesh of the tumor from micro-computerized tomography data and spatial index MPI to generate a scaled heating function for the heat transfer calculations. The processed imaging data were incorporated into a finite element solver, COMSOL Multiphysics®. The upper and lower bounds of the simulated tumor temperatures for all five cadavers demonstrated agreement with the experimental temperature measurements, thus verifying the protocol. These results demonstrate the utility of MPI to guide predictive thermal calculations for MPH treatment planning.

show abstract

A prediction model for magnetic particle imaging–based magnetic hyperthermia applied to a brain tumor model

Cited by 10 publications

References 75 publications

System integration of magnetic medical microrobots: from design to control

System integration of magnetic medical microrobots: from design to control

Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training

Magnetic Particle Imaging-Guided Thermal Simulations for Magnetic Particle Hyperthermia

Contact Info

Product

Resources

About