A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS/MND patients

Jackson, Carlayne E.; Rosenfeld, Jeffrey; Moore, Dan H.; Bryan, Wilson W.; Barohn, Richard J.; Wrench, M; Myers, Dean A.; Heberlin, L; King, R.; Smith, Jennifer A.; Gelinas, Deborah; Miller, Robert G.

doi:10.1016/s0022-510x(01)00617-7

Cited by 137 publications

(98 citation statements)

References 12 publications

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“…35 FVC may be insensitive since 13/20 patients with an FVC Ͼ70% had abnormal maximal inspiratory pressure (MIP) ϽϪ60 cm (Class III). 36 Nocturnal desaturations Ͻ90% for 1 cumulative minute was a more sensitive indicator of nocturnal hypoventilation than either FVC or MIP (Class III). 36 FVC correlated poorly with symptoms of nocturnal hypoventilation and desaturation (Class III).…”

Section: Discussionmentioning

confidence: 92%

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review)

et al. 2009

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Section: Discussionmentioning

confidence: 92%

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review)

et al. 2009

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“…FVC is not a sufficiently sensitive test to detect early respiratory involvement in ALS, and there is only a weak correlation between FVC and parameters such as MIP and MEP 22 .…”

Section: Discussionmentioning

confidence: 99%

Amyotrophic lateral sclerosis: combined nutritional, respiratory and functional assessment

Silva

Mourão

Silva

et al. 2008

Arq. Neuro-Psiquiatr.

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-Objective:To establish correlations between nutritional, functional and respiratory indices of patients with amyotrophic lateral sclerosis (ALS). Method: Twenty patients (13 appendicular -GA and 7 bulbar -GB) were included in the multidisciplinary study at the Neurological Clinic Ambulatory of the University of Campinas Hospital. Results: Among the GA type significant correlation was observed between maximal inspiratory (MIP) and expiratory (MEP) pressure (r= -0.76), MEP and pulse oxymetry (r=0.58), MIP and percent weight loss (%WL; r=0.59), and between MIP, total and subscale respiratory scores (ALSFRS-R) with %WL. With regard to the GB, correlation was found between MEP and body mass index (BMI) (r=0.97). In both GA and GB correlations were noticed between the BMI and the variables mass (kg), fat (%), arm and wrist circumference (cm), and tricipital, subscapular and supra-iliac skinfolds (mm), as well as the arm muscle circumference (cm) and fatty arm muscular area (mm 2 ). Conclusion: It is suggested that the application of simple anthropometric measurements could be useful in routine monitoring of patients with ALS.KEY WORDS: amyotrophic lateral sclerosis, nutritional support, respiratory tests, ALSFRS scale. esclerose lateral amiotrófica: correlações dos indicadores da avaliação nutricional, funcional e respiratóriaResumo -Objetivo: Correlacionar os indicadores utilizados na avaliação nutricional, funcional e respiratória de indivíduos com esclerose lateral amiotrófica (ELA). Método: Vinte pacientes (13 apendiculares -GA e 7 bulbares -GB) foram incluídos no estudo usando parâmetros nutricionais, respiratórios e escala funcional (ALSFRS-R). Resultados: Entre os pacientes do GA, as correlações observadas foram: pressão inspiratória máxima (PI max ) e expiratória máxima (PE max ) (r= -0,76); PE max e oximetria de pulso (r=0,58); PI max e porcentagem de perda de peso (%PP) (r=0,59); e entre PI max , escore ALSFRS-R com %PP. No GB, houve correlação entre MEP e índice de massa corporal (IMC) (r=0,97). Em GA e GB, observaram-se correlação entre IMC e as variáveis: massa, gordura (%), circunferência braquial e punho, pregas cutâneas tricipital, subescapular e supra-ilíaca, circunferência muscular do braço (cm), área muscular gordurosa do braço (mm 2 ). Conclusão: Sugere-se a aplicação deste conjunto de medidas durante a evolução clínica de indivíduos com ELA. PALAVRAS-CHAVE: esclerose lateral amiotrófica, suporte nutricional, testes respiratórios, escala ALSFRS-R.

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“…Therefore, vital capacity is a more sensitive measurement in the evaluation of respiratory muscle strength in the advanced stage of these diseases 14 . Jackson et al 15 , in their studies on pulmonary function in ALS, reported that most of the patients, even though their FVC was 70% above expected, had MIP lower than 60 cm H 2 O, which may reflect an early respiratory insufficiency. Our study corroborates that, since the FVC mean was 82% of the expected value and the MIP mean was 49% of what was expected.…”

Section: Resultsmentioning

confidence: 95%

Amyotrophic lateral sclerosis: prospective study on respiratory parameters

Almeida

Silva

Guerreiro

et al. 2010

Arq. Neuro-Psiquiatr.

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Objective: To verify how efficient respiratory parameters are in the follow-up of subjects with amyotrophic lateral sclerosis (ALS) and to observe possible correlations between respiratory and nutritional functions. Method: Sixteen patients with probable or defined ALS were selected and evaluated over eight months using the following respiratory parameters: spirometry, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), arterial gasometry and pulse oximetry; and nutritional parameters such as body mass index (BMI) and percentage weight loss. Results: P a CO 2 was a significant parameter to follow up disease evolution (p=0.051). There was significant correlation between MIP and MEP (r: 0.83); BMI and MIP (r: 0.70); BMI and MEP (r: 0.72); pulse oximetry and forced vital capacity (r: 0.57). Conclusion: P a CO 2 was shown to be an efficient and significant parameter in the measurement of respiratory impairment; the correlations among MIP, MEP and BMI indicated that these are significant parameters for periodic clinical evaluation. Key words: amyotrophic lateral sclerosis, maximum inspiratory pressure, maximum expiratory pressure, body mass index.Esclerose lateral amiotrófica: estudo prospectivo de parâmetros respiratórios RESUMO Objetivo: Verificar a eficácia dos parâmetros respiratórios na evolução de indivíduos com esclerose lateral amiotrófica (ELA) e identificar possíveis correlações entre função respiratória e nutricional. Método: 16 pacientes com diagnóstico provável ou definido de ELA foram selecionados por critérios definidos e avaliados, durante 8 meses, através de parâmetros respiratórios: espirometria, pressão inspiratória máxima (PIM), pressão expiratória máxima (PEM), gasometria arterial e oximetria de pulso; e parâmetros nutricionais: índice de massa corporal (IMC) e porcentagem de perda de peso. Resultados: P a CO 2 foi um parâmetro significativo para acompanhar a evolução da doença (p=0.051). Houve correlação significante entre PIM e PEM (r: 0.83); IMC e PIM (r: 0.70); IMC e PEM (r: 0.72); oximetria de pulso e capacidade vital forçada (r: 0.57). Conclusão: P a CO 2 foi marcador eficaz e significante para medir o comprometimento respiratório; correlações entre PIM, PEM e IMC indicaram ser bons parâmetros nas avaliações clínicas periódicas. Palavras-chave: esclerose lateral amiotrófica, pressão inspiratória máxima, pressão expiratória máxima, índice de massa corporal.

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A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS/MND patients

Cited by 137 publications

References 12 publications

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review)

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review)

Amyotrophic lateral sclerosis: combined nutritional, respiratory and functional assessment

Amyotrophic lateral sclerosis: prospective study on respiratory parameters

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