A Preliminary Nuclear Magnetic Resonance Metabolomics Study Identifies
Metabolites that Could Serve as Diagnostic Markers of Major Depressive
Disorder

Badamasi, Ibrahim Mohammed; Maulidiani, M.; Munn, Sann Lye; Ibrahim, Normala; Shaari, Khozirah; Stanslas, Johnson

doi:10.2174/1570159x19666210611095320

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…Currently, tumor staging and prognosis evaluation methods have limitations [ 16 – 18 ]. However, recent advancements in metabolomics offer new opportunities for identifying novel cancer diagnostic markers and prognostic assessments [ 19 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

Utilizing serum metabolomics for assessing postoperative efficacy and monitoring recurrence in gastric cancer patients

Qu,

Zhang,

Yang

et al. 2024

BMC Cancer

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Objective (1) This study aims to identify distinct serum metabolites in gastric cancer patients compared to healthy individuals, providing valuable insights into postoperative efficacy evaluation and monitoring of gastric cancer recurrence; (2) Methods: Serum samples were collected from 15 healthy individuals, 16 gastric cancer patients before surgery, 3 months after surgery, 6 months after surgery, and 15 gastric cancer recurrence patients. T-test and analysis of variance (ANOVA) were performed to screen 489 differential metabolites between the preoperative group and the healthy control group. Based on the level of the above metabolites in the recurrence, preoperative, three-month postoperative, and six-month postoperative groups, we further selected 18 significant differential metabolites by ANOVA and partial least squares discriminant analysis (PLS-DA). The result of hierarchical clustering analysis about the above metabolites showed that the samples were regrouped into the tumor-bearing group (comprising the original recurrence and preoperative groups) and the tumor-free group (comprising the original three-month postoperative and six-month postoperative groups). Based on the results of PLS-DA, 7 differential metabolites (VIP > 1.0) were further selected to distinguish the tumor-bearing group and the tumor-free group. Finally, the results of hierarchical clustering analysis showed that these 7 metabolites could well identify gastric cancer recurrence; (3) Results: Lysophosphatidic acids, triglycerides, lysine, and sphingosine-1-phosphate were significantly elevated in the three-month postoperative, six-month postoperative, and healthy control groups, compared to the preoperative and recurrence groups. Conversely, phosphatidylcholine, oxidized ceramide, and phosphatidylglycerol were significantly reduced in the three-month postoperative, six-month postoperative, and healthy control groups compared to the preoperative and recurrence groups. However, these substances did not show significant differences between the preoperative and recurrence groups, nor between the three-month postoperative, six-month postoperative, and healthy control groups; (4) Conclusions: Our findings demonstrate the presence of distinct metabolites in the serum of gastric cancer patients compared to healthy individuals. Lysophosphatidic acid, triglycerides, lysine, sphingosine-1-phosphate, phosphatidylcholine, oxidized ceramide, and phosphatidylglycerol hold potential as biomarkers for evaluating postoperative efficacy and monitoring recurrence in gastric cancer patients. These metabolites exhibit varying concentrations across different sample categories.

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Section: Discussionmentioning

confidence: 99%

Utilizing serum metabolomics for assessing postoperative efficacy and monitoring recurrence in gastric cancer patients

Qu,

Zhang,

Yang

et al. 2024

BMC Cancer

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“…A future study that could leverage on association study designs previously reported for genomic or metabolomic features in recruited participants could be done to identify the factors that may predict the weight gain associated with olanzapine 59,60 .…”

Section: Discussionmentioning

confidence: 99%

Waist-Height ratio Highlights Detrimental Risk for Olanzapine Associated Weight Gain Earlier than Body Mass Index.

Ibrahim,

Tajudeen,

Shakirat

et al. 2024

Preprint

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Patients with psychotic mental disorders, including schizophrenia, often exhibit poor dietary choices and low levels of physical activity, contributing to a higher prevalence of obesity compared to the general population. This study recruited 100 patients diagnosed with schizophrenia who had been receiving Olanzapine antipsychotic medication for at least three months, alongside 100 healthy volunteers for comparison. The average age of the schizophrenia patients was 35.56 ± 9.95 years, with a higher proportion of females in both groups. Our findings revealed significantly higher rates of abnormal Body Mass Index (BMI) (X² = 17.06, P = 0.000036; OR = 4.58, CI = 2.16–9.74) and abnormal waist-height ratio (WHtR) (X² = 35.57, P = 2.46E-9; OR = 6.37, CI = 3.39–12.00) among the schizophrenia patients compared to the healthy volunteers. Notably, BMI identified 43.3% of the schizophrenia patients as having concerning weight changes, whereas WHtR identified 64.7%, indicating that WHtR is a more sensitive measure. This discrepancy means that an additional 21.4% of schizophrenia patients would benefit from weight management guidance based on WHtR rather than BMI. Our results underscore the critical importance of WHtR in assessing adiposity among schizophrenia patients treated with Olanzapine, highlighting its value as a tool for monitoring and managing cardiometabolic risks in this population.

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“…When R2Y > 0.5 and Q2>0.5, the OPLS-DA model was considered a valid model. And the closer the accumulated values of R2Y and Q2 are to 1, the more reliable the model is [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

A comparative metabolomics study between grain-sized moxibustion and suspended moxibustion on rats with gastric ulcers

Wei,

Xie,

Pei

et al. 2023

Heliyon

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A Preliminary Nuclear Magnetic Resonance Metabolomics Study Identifies Metabolites that Could Serve as Diagnostic Markers of Major Depressive Disorder

Cited by 6 publications

References 42 publications

Utilizing serum metabolomics for assessing postoperative efficacy and monitoring recurrence in gastric cancer patients

Utilizing serum metabolomics for assessing postoperative efficacy and monitoring recurrence in gastric cancer patients

Waist-Height ratio Highlights Detrimental Risk for Olanzapine Associated Weight Gain Earlier than Body Mass Index.

A comparative metabolomics study between grain-sized moxibustion and suspended moxibustion on rats with gastric ulcers

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