A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders

Şener, Elif Funda; Sahin, Mustafa Caglar; Taheri, Serpil; Bayramov, Keziban Korkmaz; Marasli, Mert Kahraman; Zararsız, Gökmen; Canpolat, Mehmet; Şahın, Nilfer; Öztop, Didem Behice

doi:10.1080/24750573.2017.1293248

Cited by 4 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…General heritability of ASD is approximately 80% (282). Among the numerous genes associated with ASD, some have also recently been implicated in pain processing (283,284). These genes are involved in various cytomolecular mechanisms controlling of C-fiber excitability thresholds, or glutamate pathways (27) and induce alteration in pain processing, in both animal and human models (5) if muted.…”

Section: Perspectivesmentioning

confidence: 99%

“…To note, most animal models are monogenic mutation models, in contrast with human. Additional research is needed to better understand the common genetic and biomolecular pathways (283,284), and propose innovative and preventative therapeutics. Pain processing develops with age, starting during gestation, and matures with social experiences throughout life (285,286).…”

Section: Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

The Current View on the Paradox of Pain in Autism Spectrum Disorders

et al. 2022

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which affects 1 in 44 children and may cause severe disabilities. Besides socio-communicational difficulties and repetitive behaviors, ASD also presents as atypical sensorimotor function and pain reactivity. While chronic pain is a frequent co-morbidity in autism, pain management in this population is often insufficient because of difficulties in pain evaluation, worsening their prognosis and perhaps driving higher mortality rates. Previous observations have tended to oversimplify the experience of pain in autism as being insensitive to painful stimuli. Various findings in the past 15 years have challenged and complicated this dogma. However, a relatively small number of studies investigates the physiological correlates of pain reactivity in ASD. We explore the possibility that atypical pain perception in people with ASD is mediated by alterations in pain perception, transmission, expression and modulation, and through interactions between these processes. These complex interactions may account for the great variability and sometimes contradictory findings from the studies. A growing body of evidence is challenging the idea of alterations in pain processing in ASD due to a single factor, and calls for an integrative view. We propose a model of the pain cycle that includes the interplay between the molecular and neurophysiological pathways of pain processing and it conscious appraisal that may interfere with pain reactivity and coping in autism. The role of social factors in pain-induced response is also discussed. Pain assessment in clinical care is mostly based on subjective rather than objective measures. This review clarifies the strong need for a consistent methodology, and describes innovative tools to cope with the heterogeneity of pain expression in ASD, enabling individualized assessment. Multiple measures, including self-reporting, informant reporting, clinician-assessed, and purely physiological metrics may provide more consistent results. An integrative view on the regulation of the pain cycle offers a more robust framework to characterize the experience of pain in autism.

show abstract

Section: Perspectivesmentioning

confidence: 99%

Section: Perspectivesmentioning

confidence: 99%

The Current View on the Paradox of Pain in Autism Spectrum Disorders

et al. 2022

View full text Add to dashboard Cite

show abstract

Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders

Şener

Taheri

Sahin³

et al. 2018

J Mol Neurosci

View full text Add to dashboard Cite

Aggression Dimensions in Students with Autism

Elkhamisi

Almutery²

2018

ESJ

View full text Add to dashboard Cite

The current study is intended to explore the prevalence of aggression level of students with autism based on gender, age, and intellectual state. The study sample is composed of parents for (108) of children with autism. These students are aged 5-16 years old who have been attending the autism centers in the State of Kuwait. The current study has utilized a three-dimensional aggression scale, which includes aggression toward others, aggression toward self, and aggression toward things. The result of the study reveals that among the participant's aggression toward others has been ranked the highest on subscale, followed by aggression toward self, and lastly aggression toward things. The study further exposed that the most significant aspects of aggression were explicit obstinacy and refusal when asking the participant to perform an action, the act of pinching others in a state of anger, kicking others without any legit or obvious reason, throwing himself on the floor, and hitting himself with his hand or any other part of his body. In addition, the results of the study suggests that there are a statistically significant differences based on gender in aggression toward things, which is in favour of female. No statistically significant difference has been observed based on gender on aggression toward others. As per the total score of aggression scale, there is no statistically significant difference found based on age or intellectual state of all aggression subscales.

show abstract

A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders

Cited by 4 publications

References 31 publications

The Current View on the Paradox of Pain in Autism Spectrum Disorders

The Current View on the Paradox of Pain in Autism Spectrum Disorders

Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders

Aggression Dimensions in Students with Autism

Contact Info

Product

Resources

About