A preliminary study on the influence of glutathione S transferase T1 (GSTT1) as a risk factor for late onset Alzheimer's disease in North Indian population

Ghosh, T. K.; Mustafa, Md.; Kumar, Vivek; Datta, Sudip Kumar; Bhatia, M. L.; Sircar, Sabyasachi; Banerjee, Basu Dev

doi:10.1016/j.ajp.2012.02.023

Cited by 36 publications

(22 citation statements)

References 16 publications

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“…The reduction in the studied antioxidant enzymes is in agreement with Abdollahi et al and El‐Demerdash who reported that the decrease in antioxidant enzymes and increase in LPO could explain the induction of free radicals in chlorpyrifos‐treated rats and lambda‐cyhalothrin treated rabbit erythrocytes, respectively . Glutathione S‐transferases (GSTs), a family of phase‐II isoenzymes, play a critical role in providing protection against electrophiles and products of oxidative stress . The present results coincide with the study of Ranjbar et al who reported that GST is one of the enzyme system involved in the detoxification of organophosphorus insecticides to non‐toxic products or by rapidly binding and very slowly turning over the insecticide .…”

Section: Discussionsupporting

confidence: 92%

Modulatory effect of Turnera diffusa against testicular toxicity induced by fenitrothion and/or hexavalent chromium in rats

El‐Demerdash

Jebur

Nasr

et al. 2018

Environmental Toxicology

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Oxidative stress and increased production of reactive oxygen species have been implicated in pesticides and heavy metals toxicity. The objective of this study was to investigate the efficacy of Turnera diffusa Willd (damiana) on counteracting fenitrothion (FNT) and/or potassium dichromate (CrVI)-induced testicular toxicity and oxidative injury in rats. FNT and/or CrVI intoxicated animals revealed a significant increase in thiobarbituric acid reactive substances and hydrogen peroxide levels. While, reduced glutathione and protein content, as well as antioxidant enzymes, phosphatases, and aminotransferases activities, were significantly decreased. In addition, significant changes in testosterone and follicle-stimulating hormone levels were detected. Furthermore, histological and immunohistochemical alterations were observed in rat testes and this supported the observed biochemical changes. On the other hand, rats treated with damiana alone decreased lipid peroxidation and increased most of the examined parameters. Moreover, damiana pretreatment to FNT and/or CrVI-intoxicated rats showed significant improvement in lipid peroxidation, enzyme activities, and hormones as compared with their respective treated groups. Conclusively, rats treated with both FNT and/or CrVI showed pronounced hazardous effect especially in their combination group in addition, Turnera diffusa had a potential protective role against FNT and/or CrVI induced testicular toxicity. K E Y W O R D Schromium hexavalent, fenitrothion, oxidative stress, rat testes, Turnera diffusa

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Section: Discussionsupporting

confidence: 92%

Modulatory effect of Turnera diffusa against testicular toxicity induced by fenitrothion and/or hexavalent chromium in rats

El‐Demerdash

Jebur

Nasr

et al. 2018

Environmental Toxicology

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“…Alterations in the expression of GST isoenzymes in brain have been connected to neurological disorders including Alzheimeŕs disease [142], epilepsy [143] and Parkinsońs disease [144,145]. However, it remains to be elucidated whether the expression or activity of astrocytic GSTs are altered in such diseases.…”

Section: Conjugation Of Gsh With Endogenous Compounds and Xenobioticsmentioning

confidence: 97%

Glutathione-Dependent Detoxification Processes in Astrocytes

et al. 2014

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Astrocytes have a pivotal role in brain as partners of neurons in homeostatic and metabolic processes. Astrocytes also protect other types of brain cells against the toxicity of reactive oxygen species and are considered as first line of defence against the toxic potential of xenobiotics. A key component in many of the astrocytic detoxification processes is the tripeptide glutathione (GSH) which serves as electron donor in the GSH peroxidase-catalyzed reduction of peroxides. In addition, GSH is substrate in the detoxification of xenobiotics and endogenous compounds by GSH-S-transferases which generate GSH conjugates that are efficiently exported from the cells by multidrug resistance proteins. Moreover, GSH reacts with the reactive endogenous carbonyls methylglyoxal and formaldehyde to intermediates which are substrates of detoxifying enzymes. In this article we will review the current knowledge on the GSH metabolism of astrocytes with a special emphasis on GSH-dependent detoxification processes.

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“…Recent studies suggest that GST P1-1 is involved in Cdk5 regulation by the modulation of its expression in AD patients and therefore prevents neurodegeneration (Sun et al, 2011). GST T1-1: Deletion of GSTT1 is associated with an increased susceptibility to contract Parkinson's disease, motor neuron disease and Alzheimer's disease (Ghosh et al, 2012;Singh et al, 2008;Stroombergen and Waring, 1999). Therefore, the presence of GSTT1 may indicate protection from the disease.…”

Section: Glutathione Transferasesmentioning

confidence: 96%