A pressure-induced amorphous phase transition in magnesium-substituted -tricalcium phosphate

Scott, Paul R.; Crow, Joseph; LeGeros, Racquel Z.; Krüger, Michael

doi:10.1016/j.ssc.2011.07.019

Cited by 8 publications

(11 citation statements)

References 11 publications

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“…In addition, a crystalline to amorphous transition has been detected for various calcium orthophosphates at very high (up to 10 GPa) pressures (Fig. 6) [160,161,347]. Figure 6.…”

Section: Mechanical and Pressure-induced Techniquesmentioning

confidence: 99%

“…As the majority of calcium orthophosphates are crystalline, this review is devoted to the detailed description of ACPs (emphasized by bold font in Table 1), which is of a great biomedical importance due to its chemical and structural similarities to the calcified tissues of mammals. Furthermore, with a few important exceptions, neither ion-substituted forms of ACP [34][35][36][37][38][39][40][41][42][43][44][45][46][47]347], nor ACP-containing biocomposites are considered and discussed. The readers interested in either these topics and/or other types of amorphous calcium phosphates (e.g., amorphous calcium polyphosphate [76][77][78][79][80] and amorphous calcium metaphosphate [81]) are referred to the original publications.…”

Section: Introductionmentioning

confidence: 99%

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Amorphous Calcium Orthophosphates: Nature, Chemistry and Biomedical Applications

Dorozhkin¹

2012

IJMC

124

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Amorphous calcium orthophosphates (ACPs) represent a unique class of biomedically relevant calcium orthophosphate salts, having variable chemical but rather identical glass-like physical properties, in which there are neither translational nor orientational long-range orders of the atomic positions. Normally, ACPs are the first solid phases, precipitated after a rapid mixing of aqueous solutions containing ions of Ca 2+ and PO 4 3-; however, other production techniques are known. Interestingly, but ACPs prepared by wet-chemical techniques were found to possess a relative constancy in their chemical composition over a relatively wide range of preparation conditions, which suggested the presence of a well-defined local structural unit, presumably, with the structure of Ca 9 (PO 4 ) 6 -so-called a Posner's cluster. However, the presence of similar clusters in ACPs produced by other techniques remains uncertain. All ACPs are thermodynamically unstable compounds and, unless stored in dry conditions or doped by stabilizers, spontaneously they tend to transform to crystalline calcium orthophosphates, mainly to calcium apatites. This solution instability of ACPs and their easy transformation to crystalline phases are of a great biological relevance. Namely, the initiating role ACPs play in matrix vesicle biomineralization raises the importance of ACPs from a mere laboratory curiosity to that of a reasonable key intermediate in skeletal calcification. In addition, due to great chemical and structural similarities to the calcified tissues of mammals, as well as excellent biocompatibility and bioresorbability, all types of ACPs are very promising candidates to manufacture artificial bone grafts. In this review, current knowledge on occurrence, preparation, composition, structure, major properties and biomedical applications of ACPs have been summarized. To assist the readers in looking for the specific details on ACPs, a great number of references have been collected and systematized.

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“…In addition, a crystalline to amorphous transition has been detected for various calcium orthophosphates at very high (up to 10 GPa) pressures (Fig. 6) [160,161,347]. Figure 6.…”

Section: Mechanical and Pressure-induced Techniquesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amorphous Calcium Orthophosphates: Nature, Chemistry and Biomedical Applications

Dorozhkin¹

2012

IJMC

124

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“…Bone formation markers (ALP and osteocalcin) and bone resorption markers (TGF‐ β and collagen) activity in MC3T3‐E1 cell line had a higher expression for β‐TCP group, followed by β‐TCMP and BCMP group, as shown on Figure . This behavior can be explained for the fact that the presence of Mg ions retards the dissolution of CaPs due to increase of structural stability . The reason why Mg stabilizes the structure of TCP may reside in the fact that Mg atoms are located closer to the axis of the cluster than the Ca atoms, due to their smaller ionic radius .…”

Section: Resultsmentioning

confidence: 99%

“…This behavior can be explained for the fact that the presence of Mg ions retards the dissolution of CaPs 20 due to increase of structural stability. 4,7,21 The reason why Mg stabilizes the structure of TCP may reside in the fact that Mg atoms are located closer to the axis of the cluster than the Ca atoms, due to their smaller ionic radius. 21 Yassuda et al showed, in their in vivo study, that b-TCP granules had a positive influence on osteoclast activity compared to b-TCMP granules.…”

Section: Resultsmentioning

confidence: 99%

“…3 Consequently, magnesium (Mg) is frequently incorporated in calcium phosphates and in composite materials as they are considered promising materials for bone engineering. 3,7,8 Mg is one of the most important ions present in biological hard tissue; it plays a significant role in bone growth, because it influences osteoblast and osteoclast activity. 4,9 In addition, substituting Mg for Ca is known to stabilize b-TCP.…”

Section: Introductionmentioning

confidence: 99%

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Beta‐type calcium phosphates with and without magnesium: From hydrolysis of brushite powder to robocasting of periodic scaffolds

Richard

Sader

Dai

et al. 2013

J Biomedical Materials Res

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Several approaches have attempted to replace extensive bone loss, but each of them has their limitation. Nowadays, additive manufacture techniques have shown great potential for bone engineering. The objective of this study was to synthesize beta tricalcium phosphate (β-TCP), beta tricalcium phosphate substituted by magnesium (β-TCMP), and biphasic calcium phosphate substituted by magnesium (BCMP) via hydrolysis and produce scaffolds for bone regeneration using robocasting technology. Calcium deficient apatites, with and without magnesium were obtained by hydrolysis, calcined and physico-chemically characterized. Colorimetric cell viability assay, calcium nodule formation, and the expression of alkaline phosphatase, osteocalcin, transforming growth factor beta-1 and collagen were assessed using a mouse osteoblastic cell line (MC3T3-E1). Direct-write assembly of cylindrical periodic scaffolds was done via robotic deposition using β-TCP, β-TCMP, and BCMP colloidal inks. The sintered scaffolds were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, Archimede's method, and uniaxial compression test. According to the cell viability assay, the powders induced cell proliferation. Calcium nodule formation and bone markers activity suggested that the materials present potential value in bone tissue engineering. The scaffolds built by robocasting presented interconnected porous and exhibited mean compressive strength between 7.63 and 18.67 MPa, compatible with trabecular bone.

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Equations of State and Crystal Structures of KCaPO₄, KSrPO₄, and K₂Ce(PO₄)₂ under High Pressure: Discovery of a New Polymorph of KCaPO₄

Errandonea

Achary

Díaz-Anichtchenko

et al. 2023

Crystal Growth & Design

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We have studied by means of angle-dispersive powder synchrotron X-ray diffraction the structural behavior of KCaPO 4 , SrKPO 4 , and K 2 Ce(PO 4 ) 2 under high pressure up to 26, 25, and 22 GPa, respectively. For KCaPO 4 , we have also accurately determined the crystal structure under ambient conditions, which differs from the structure previously reported. Arguments supporting our structural determination will be discussed. We have found that KCaPO 4 undergoes a reversible phase transition. The onset of the transition is at 5.6 GPa. It involves a symmetry decrease. The low-pressure phase is described by space group P3̅ m1 and the high-pressure phase by space group Pnma. For KSrPO 4 and K 2 Ce(PO 4 ) 2 , no evidence of phase transitions has been found up to the highest pressure covered by the experiments. For the three compounds, the linear compressibility for the different crystallographic axes and the pressure−volume equation of states are reported and compared with those of other phosphates. The three studied compounds are among the most compressible phosphates. The results of the study improve the knowledge about the high-pressure behavior of complex phosphates.

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A pressure-induced amorphous phase transition in magnesium-substituted -tricalcium phosphate

Cited by 8 publications

References 11 publications

Amorphous Calcium Orthophosphates: Nature, Chemistry and Biomedical Applications

Amorphous Calcium Orthophosphates: Nature, Chemistry and Biomedical Applications

Beta‐type calcium phosphates with and without magnesium: From hydrolysis of brushite powder to robocasting of periodic scaffolds

Equations of State and Crystal Structures of KCaPO₄, KSrPO₄, and K₂Ce(PO₄)₂ under High Pressure: Discovery of a New Polymorph of KCaPO₄

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A pressure-induced amorphous phase transition in magnesium-substituted -tricalcium phosphate

Cited by 8 publications

References 11 publications

Amorphous Calcium Orthophosphates: Nature, Chemistry and Biomedical Applications

Amorphous Calcium Orthophosphates: Nature, Chemistry and Biomedical Applications

Beta‐type calcium phosphates with and without magnesium: From hydrolysis of brushite powder to robocasting of periodic scaffolds

Equations of State and Crystal Structures of KCaPO4, KSrPO4, and K2Ce(PO4)2 under High Pressure: Discovery of a New Polymorph of KCaPO4

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Equations of State and Crystal Structures of KCaPO₄, KSrPO₄, and K₂Ce(PO₄)₂ under High Pressure: Discovery of a New Polymorph of KCaPO₄