A preventive measure for otitis media in children with upper respiratory tract infections

Mora, Renzo; Barbieri, Marco; Passàli, Giulio Cesare; Sovatzis, A.; Mora, Francesco; Cordone, M

doi:10.1016/s0165-5876(01)00649-8

Cited by 34 publications

(20 citation statements)

References 20 publications

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“…In this context, preventive strategies, such as ribosomal immunotherapy, may represent a valid alternative approach [3].…”

Section: Discussionmentioning

confidence: 99%

“…Because of the presence of proteoglycans and ribosomes from four frequently encountered bacterial strains, ''Immucytal'' has specific immunostimulant properties. It can stimulate both the non-specific immune response and the specific antibody production [3,13].…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of AOM involves a complex interplay between viruses, bacteria and the host's inflammatory response [3].…”

Section: Introductionmentioning

confidence: 99%

“…In the last years, several studies have demonstrated the immunostimulant activity of various bacterial extracts, which seems to target not only the bacteria from which such extracts are made but also (trough non-specific mechanism) other pathogens responsible for the most respiratory tract infections [3,8].…”

Section: Introductionmentioning

confidence: 99%

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Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Mora

Ralli

Maria

et al. 2004

International Journal of Pediatric Otorhinolaryngology

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SummaryThe aim of this study was to compare the efficacy and the safety of a short oral ribosomal immunotherapy (Immucytal) in the prevention of chronic otitis media in children. Seventy-two patients were enrolled in this study, 41 males and 31 females, aged between 6 and 14 years, with an history of recurrent otitis media. Patients were randomised to receive Immucytal (group A) or placebo (group B) according to the following protocol: one tablet daily in the morning 8 days per month for three consecutive months. Immucytal and placebo were identical in shape and size, in order to maintain double-blind conditions. The efficacy parameters were (evaluated before, at the end and 6 months after the beginning of the therapy): clinical score; changes in immunological parameters; patient's parents assessment of symptoms on a scale from 0 (much worse) to 4 (much improved) and hearing tests. Patients of group A, had an improvement of clinical items measured, serum concentrations of immunoglobulins, subjective patient's parents assessment of symptoms and hearing tests. For all evaluations, a significant difference between treatment groups was found. Using this dosage and posology (shorter than others) the beneficial effects of Immucytal were maintained until the end of the 6-month study period.

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“…In this context, preventive strategies, such as ribosomal immunotherapy, may represent a valid alternative approach [3].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of AOM involves a complex interplay between viruses, bacteria and the host's inflammatory response [3].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Mora

Ralli

Maria

et al. 2004

International Journal of Pediatric Otorhinolaryngology

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“…Особо было отмечено, что у 74% детей с исходно сниженным слухом вследствие ранее перенесенных эпизодов среднего экссудативного отита, снижение частоты обострений со-провождалось тенденций к нормализации показателей аудиограммы. В последующих двойных слепых рандоми-зированных плацебо-контролируемых исследованиях также было показано, что применение рибомунила при-водит к снижению частоты эпизодов среднего отита при ОРВИ у детей с рекуррентными респираторными инфек-циями [43,44]. При этом, помимо клинического эффекта, достигнутого у 74% пациентов, отмечали также и высокую экономическую результативность рибосомальной имму-низации [44].…”

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Immunoprophylaxis of infections of the upper respiratory tract in the frequently ill children

Ep¹,

Zaplatnikov²,

Da³

2015

Vestn. otorinolaringol.

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В повседневной практике врачи нередко пользуются определением «часто болеющие дети» (ЧБД), выделяя группу детей с более высоким, чем у сверстников, уров-нем заболеваемости респираторными инфекциями [1,2]. Это определяет необходимость уточнения причин и нозо-логической верификации причин рецидивов инфекций респираторного тракта в каждом конкретном случае. У большинства больных при этом имеют место острые по-ражения верхнего отдела дыхательных путей, обусловлен-ные респираторными вирусами. Острые респираторные вирусные инфекции (ОРВИ), как правило, протекают в легкой форме и заканчиваются самовыздоровлением па-циентов на 5-10-й дни заболевания. Однако в ряде случа-ев отмечаются бактериальные осложнения ОРВИ в виде острого среднего отита, аденоидита, риносинусита [3][4][5][6].Острый средний отит (ОСО) является самым частым бактериально ассоциированным осложнением ОРВИ у детей дошкольного возраста. Так, по материалам зарубеж-ной литературы, у детей раннего возраста ОСО, как ос-ложнение ОРВИ, развивается в 37% случаев [7]. По дан-ным отечественных авторов, 44% детей переносят хотя бы один эпизод ОСО на первом году жизни, а 7-8% -3 эпи-

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Immunostimulating agents for the prevention of acute otitis media

Williamson¹,

Mar²,

Crosby³

et al. 2004

The Cochrane Database of Systematic Reviews

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A preventive measure for otitis media in children with upper respiratory tract infections

Cited by 34 publications

References 20 publications

Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Immunoprophylaxis of infections of the upper respiratory tract in the frequently ill children

Immunostimulating agents for the prevention of acute otitis media

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