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Abstract

The prostate, an exocrine gland of the male reproductive system, secretes a fluid that enhances sperm motility, prolongs sperm survival, and protects the genetic material contained within. Prostate enlargement due to nonmalignant hyperplasia is a common condition in older men, while prostate cancer represents one of the most common cancers in men in the West, as well as a significant cause of death. The in vitro modeling of the normal and diseased prostate through advanced three-dimensional (3D) culture techniques aims to explore