A primary mediastinal germ cell tumor of yolk sac type: case report

Darif, Khadija; Benbrahim, Zineb; Acharfi, Nisrine; Khacha, Anass; Maâroufi, Mustapha; Amaadour, Lamiae; Oualla, Karima; Arifi, Samia; Mellas, Nawfel

doi:10.11604/pamj.2021.38.330.23730

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Endodermal sinus or yolk sac tumor (YST) is a rare malignant extragonadal NSGC tumor [5] . The World Health Organization (WHO) has divided germ cell tumors into 2 groups.…”

Section: Discussionmentioning

confidence: 99%

“…Though extremely rare, brain metastases in primary mediastinal YST have a poor prognosis. Signs and symptoms are not specific, so physicians should be more aware and reevaluate patient diagnosis [5] . As opposed to a single treatment, multimodal treatment, including pre-chemotherapy, surgery, and post-surgical chemotherapy, gives better outcomes.…”

Section: Discussionmentioning

confidence: 99%

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A rare case of brain metastatic of primary mediastinal yolk sac tumor

Cecilia¹,

Ardiansyah²,

Fadil³

2023

Radiology Case Reports

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“…Endodermal sinus or yolk sac tumor (YST) is a rare malignant extragonadal NSGC tumor [5] . The World Health Organization (WHO) has divided germ cell tumors into 2 groups.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A rare case of brain metastatic of primary mediastinal yolk sac tumor

Cecilia¹,

Ardiansyah²,

Fadil³

2023

Radiology Case Reports

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“…The following key words were used for the database search: “yolk sac tumor,” “mediastinum,” “mediastinal.” A total of 73 articles were retrieved, in which 22 articles on the therapy and prognosis of PMYST were extracted, including 16 case reports and 6 case series, involving 52 patients in total. 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 Out of all the patients, only six female cases were reported. The ages of all the patients ranged from 1 to 73 years old with a mean age of 23.64 years.…”

Section: Literature Reviewmentioning

confidence: 99%

“…In PubMed, the English case reports and case series of PMYST during the past decade were searched. The following key words were used for the database search: “yolk sac tumor,” “mediastinum,” “mediastinal.” A total of 73 articles were retrieved, in which 22 articles on the therapy and prognosis of PMYST were extracted, including 16 case reports and 6 case series, involving 52 patients in total 5–26 . Out of all the patients, only six female cases were reported.…”

Section: Literature Reviewmentioning

confidence: 99%

Primary mediastinal yolk sac tumor: A case report and literature review

Zhang

2023

Clinical Case Reports

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Key Clinical MessageThere are limited published cases of primary mediastinal yolk sac tumor (PMYST), with no consensus on the best treatment alternative. By far, the surgery oriented comprehensive therapies are the main treatment methods. The surgical strategy should be individualized and aimed at radical resection, considering all the possibilities, including the use of cardiopulmonary bypass and prosthetic materials.AbstractA 15‐year‐old boy was diagnosed as PMYST. The tumor, with a size about 13 × 12 × 8 cm, was located in the right upper mediastinum, closely adhering to ascending aorta, superior vena cava, right atrium, and the right hilum. After 6 cycles chemotherapy of bleomycin, etoposide, and cisplatin (BEP), no significant change was found in the size of tumor. Subsequently, an extended tumor excision including partial resection of the right lung, the pericardium, the diaphragm and the right phrenic nerve, was performed successfully with cardiopulmonary bypass on standby. During 6 months of follow‐up, there was no tumor recurrence. Meanwhile, in PubMed, we searched the English case reports and case series of PMYST during the past decade. A total of 73 articles were retrieved, in which 22 articles on the therapy and prognosis of PMYST were extracted and reviewed, included 16 case reports and 6 case series with a total of 52 patients. Due to the rarity of PMYST, it is difficult to provide a specific treatment regimen. The surgery‐oriented comprehensive therapies are still the main treatment methods. The surgical strategy should be individualized and aim at radical resection, considering all the possibilities, including the use of cardiopulmonary bypass and prosthetic materials.

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Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

Vandaele,

Van Slambrouck,

Schöffski

et al. 2024

World J Surg Onc

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Background Pleural neoplasms are rare and can be subdivided into pleural metastasis and primary pleural neoplasms. Non-mesothelioma primary pleural neoplasms are a diverse group of extremely rare pathologies. Case presentation In this case series, we describe the presentation and management of two rare primary pleural neoplasms. A first case describes a primary pleural yolk sac tumor treated with neoadjuvant chemotherapy, extended pleurectomy decortication, and hyperthermic intrathoracic chemotherapy. In a second case we describe the management of a primary pleural synovial sarcoma by neoadjuvant chemotherapy and extrapleural pneumonectomy. A complete resection was obtained in both cases and the post-operative course was uncomplicated. No signs of tumor recurrence were noted during follow-up in the first patient. In the second patient a local recurrence was diagnosed 6 months after surgery. Conclusion Neo-adjuvant chemotherapy followed by extensive thoracic surgery, including hyperthermic intrathoracic chemotherapy, is a feasible treatment strategy for non-mesothelioma primary pleural neoplasms, but careful follow-up is required.

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A primary mediastinal germ cell tumor of yolk sac type: case report

Cited by 4 publications

References 7 publications

A rare case of brain metastatic of primary mediastinal yolk sac tumor

A rare case of brain metastatic of primary mediastinal yolk sac tumor

Primary mediastinal yolk sac tumor: A case report and literature review

Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

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