A Primer into the Current State of Artificial Intelligence in Gastroenterology

Moldoveanu, Alexandru Constantin; Fierbinţeanu-Braticevici, Carmen

doi:10.15403/jgld-4180

Cited by 4 publications

(2 citation statements)

References 96 publications

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“…Further investigation of these test results may also benefit from analysis with artificial intelligence models, which would allow the correlation of a large number of other parameters [ 37 ]…”

Section: Discussionmentioning

confidence: 99%

The Role of Noninvasive 13C-Octanoate Breath Test in Assessing the Diagnosis of Nonalcoholic Steatohepatitis

Fierbinţeanu-Braticevici

Calin-Necula

Enciu

et al. 2022

Diagnostics

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Background: The diagnosis of NASH needs a liver biopsy, an invasive procedure that is not frequently accepted by patients. The aim of our study was to evaluate the efficacy of the 13C-Octanoate breath test (OBT) as a non-invasive surrogate marker to differentiate patients with NASH from patients with simple steatosis (NAFL). Methods: We performed a prospective study on patients with histologically established non-alcoholic steatohepatitis and no other hepatic disease. Each patient underwent a testing protocol, which included a clinical exam, laboratory blood tests, standard abdominal ultrasound, and a 13C-Octanoate breath test. Results: The study group included: 82 patients with steatohepatitis, 64 patients with simple steatosis, and 21 healthy volunteers. The univariate and bivariate analysis identified that significant values were the percent dose recovery (PDR) at 15 min—r = 0.65 (AUROC = 0.902) and cumulative percent dose recovery (cPDR) at 120 min—r = 0.69 (AUROC = 0.899). Discussion: Our study showed that 13C-OBT had good efficacy for identifying patients with NASH from those with NAFL (steatosis alone) but not those with NAFL from healthy subjects. Considering all these pathogenic steps in NASH we considered that OBT could have the clinical utility to identify patients at risk for NASH, especially “fast progressors”.

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Section: Discussionmentioning

confidence: 99%

The Role of Noninvasive 13C-Octanoate Breath Test in Assessing the Diagnosis of Nonalcoholic Steatohepatitis

Fierbinţeanu-Braticevici

Calin-Necula

Enciu

et al. 2022

Diagnostics

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“…The importance of this finding is the potential identification of increased portal resistance in the absence of fibrosis, due to the higher stiffness of the lipid droplets in comparison to hepatocytes’ cytoplasm [ 23 ], however, this will need to be investigated in future studies. Other potential new directions for research could include the application of artificial intelligence (AI) to these parameters, as some AI algorithms have already been applied to the histopathological exam [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of 13C-Methacetin and 13C-Octanoate Breath Test for the Evaluation of Nonalcoholic Steatohepatitis

Fierbinţeanu-Braticevici

Enciu

Calin-Necula

et al. 2023

JCM

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Background: While non-alcoholic fatty liver disease (NAFLD) is a wide-spread liver disease, only some patients progress towards steatohepatitis and cirrhosis. Aim: We comparatively analyzed the methacetin breath test (MBT) for the microsomal function of the liver and the octanoate breath test (OBT) for mitochondrial activity, in detecting patients with steatohepatitis and estimating fibrosis. Methods: 81 patients with histologically proven NAFLD (SAF score) were evaluated. The parameters used for both breath tests were the dose/h and the cumulative dose recovery at multiple timepoints. The statistical association between histological diagnosis and breath test results used Independent Samples t Test. The accuracy for diagnosis was evaluated using area under the receiver operator characteristic (AUROC) and the sensitivity and specificity were assessed using the Youden J method. Results: Both MBT and OBT were able to differentiate patients with simple steatosis from NASH and to stratify patients with significant fibrosis and cirrhosis (p-values < 0.001 for most analyzed timepoints). The best parameter for NASH diagnosis was OBT dose at 30 min. In the case of significant fibrosis, the most accurate test was MBT cumulative dose at 30 min. Conclusions: Both MBR and OBT tests are potentially useful tools in assessing patients with NAFLD.

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Telemedizin und KI-gestützte Diagnostik im Alltag der Viszeralmedizin

Grade,

Uslar

2024

Chirurgie

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ZusammenfassungDie Fortschritte von Augmented (AR) und Virtual Reality (VR) in der Telemedizin sind rasant. Eine über die Distanz verfügbare AR konnte beispielsweise bereits erfolgreich in der Krisenintervention, z. B. in Kriegsgebieten, eingesetzt werden. Vielversprechend erscheinen die Potenziale der Telemedizin auch in strukturschwachen Gebieten oder in der Hinzuschaltung von Expertinnen oder Experten in Notaufnahmesituationen. Der Einsatz von Avataren in der Telemedizin bedarf noch weiterer Forschung und Entwicklung, um das Gefühl der Präsenz zu verbessern und damit die Akzeptanz zu erhöhen. Künstliche Intelligenz in der Endoskopie v. a. in der Koloskopie ist bereits in vielen gastroenterologischen Abteilungen gelebte tägliche Praxis. Über eine erhöhte Adenomdetektionsrate (ADR) ist der Benefit klar belegt. Studien konnten zudem eine im Vergleich zur Kontrollgruppe erhöhte Detektionsrate für sessile serratierte Adenome (SSA) und eine signifikant erhöhte Rate an dysplastischen Barrett-Arealen im oberen Gastrointestinal(GI)-Trakt (eventuelle Barrett-Karzinome) zeigen.

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A Primer into the Current State of Artificial Intelligence in Gastroenterology

Cited by 4 publications

References 96 publications

The Role of Noninvasive 13C-Octanoate Breath Test in Assessing the Diagnosis of Nonalcoholic Steatohepatitis

The Role of Noninvasive 13C-Octanoate Breath Test in Assessing the Diagnosis of Nonalcoholic Steatohepatitis

A Comparison of 13C-Methacetin and 13C-Octanoate Breath Test for the Evaluation of Nonalcoholic Steatohepatitis

Telemedizin und KI-gestützte Diagnostik im Alltag der Viszeralmedizin

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