A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China

Weng, Wubin; Dong, Meng‐Jie; Zhang, Jun; Yang, Jun; Zhang, Bo; Zhao, Xingdong

doi:10.1097/md.0000000000007279

Cited by 17 publications

(22 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another recent study in Chinese school‐children, the odds ratio (OR) for total goiter rate per 50 μg iodine intake increments rose from 0.9 (95% CI: 0.2–3.9) at an estimated daily iodide intake of 150–199 μg, to 14.2 (95% CI: 4.8–42.7) at >600 μg iodine/day . A recent meta‐analysis that compiled data from 43 Chinese studies, grouped them by iodine status, found a lower prevalence of thyroid nodules in the excessive iodine intake group compared with those with adequate or deficient intakes (7%, 25%, and 22%, respectively) …”

Section: Thyroid Disorders Associated With Iodine Excessmentioning

confidence: 99%

“…The development of hypothyroidism following chronic excess iodine exposure may be due to increased thyroid autoimmunity, the presence of elevated antithyroid antibodies …”

Section: Thyroid Disorders Associated With Iodine Excessmentioning

confidence: 99%

“…56 A recent meta-analysis that compiled data from 43 Chinese studies, grouped them by iodine status, found a lower prevalence of thyroid nodules in the excessive iodine intake group compared with those with adequate or deficient intakes (7%, 25%, and 22%, respectively). 130 Goiter has been associated with excessive iodine intakes in Sudan, 131 Ethiopia, 132 Algeria, [132][133][134] and China. 56,[62][63][64][65] Lv et al investigated the reversibility of iodine-induced goiter following the initiation of a Chinese policy to remove iodized salt from regions with a high water iodine concentration.…”

Section: Increased Thyroidal Volume and Goitermentioning

confidence: 99%

“…139 The development of hypothyroidism following chronic excess iodine exposure may be due to increased thyroid autoimmunity, the presence of elevated antithyroid antibodies. 57,130,140 Thyroid autoimmunity Excessive iodine consumption has been widely described as a risk factor for the development of thyroid autoimmunity. 6,97,116,141,142 The association between autoimmunity and disease is complex; a diagnosis of autoimmune disease is made using positive antibody titers, yet individuals may have positive titers of autoantibodies and no disease, or disease and a negative titer.…”

Section: Hypothyroidismmentioning

confidence: 99%

See 3 more Smart Citations

Excess iodine intake: sources, assessment, and effects on thyroid function

Farebrother

Zimmermann

Andersson

2019

Annals of the New York Academy of Sciences

206

131

View full text Add to dashboard Cite

Iodine is essential for thyroid hormone synthesis. High iodine intakes are well tolerated by most healthy individuals, but in some people, excess iodine intakes may precipitate hyperthyroidism, hypothyroidism, goiter, and/or thyroid autoimmunity. Individuals with preexisting thyroid disease or those previously exposed to iodine deficiency may be more susceptible to thyroid disorders due to an increase in iodine intake, in some cases at intakes only slightly above physiological needs. Thyroid dysfunction due to excess iodine intake is usually mild and transient, but iodine‐induced hyperthyroidism can be life‐threatening in some individuals. At the population level, excess iodine intakes may arise from consumption of overiodized salt, drinking water, animal milk rich in iodine, certain seaweeds, iodine‐containing dietary supplements, and from a combination of these sources. The median urinary iodine concentration (UIC) of a population reflects the total iodine intake from all sources and can accurately identify populations with excessive iodine intakes. Our review describes the association between excess iodine intake and thyroid function. We outline potential sources of excess iodine intake and the physiological responses and consequences of excess iodine intakes. We provide guidance on choice of biomarkers to assess iodine intake, with an emphasis on the UIC and thyroglobulin.

show abstract

Section: Thyroid Disorders Associated With Iodine Excessmentioning

confidence: 99%

“…The development of hypothyroidism following chronic excess iodine exposure may be due to increased thyroid autoimmunity, the presence of elevated antithyroid antibodies …”

Section: Thyroid Disorders Associated With Iodine Excessmentioning

confidence: 99%

Section: Increased Thyroidal Volume and Goitermentioning

confidence: 99%

Section: Hypothyroidismmentioning

confidence: 99%

See 2 more Smart Citations

Excess iodine intake: sources, assessment, and effects on thyroid function

Farebrother

Zimmermann

Andersson

2019

Annals of the New York Academy of Sciences

206

131

View full text Add to dashboard Cite

show abstract

“…In the article, “A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China”, [ 1 ] Jun Zhang's name appeared incorrectly.…”

mentioning

confidence: 99%