A probiotic lozenge administered medical device and its effect on salivary mutans streptococci and lactobacilli

Çağlar, Eşber; Kuşcu, Özgür Önder; Çıldır, Şule Kavaloğlu; Kuvvetli, Senem Selui; Sandallı, Nüket

doi:10.1111/j.1365-263x.2007.00866.x

Cited by 133 publications

(91 citation statements)

References 17 publications

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“…[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] All used parallel arms with intervention versus placebo/control, or a crossover design. The sample sizes were generally small and the interventions were shorter than 1 month.…”

Section: Clinical Trials With Microbial Endpointsmentioning

confidence: 99%

Are we ready for caries prevention through bacteriotherapy?

Twetman

2012

Braz. oral res.

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Recent insights in medical science indicate that human biofilms play an important role in health and well-being, and have put microbiota modulation through bacteriotherapy into focus. In dentistry, bacterial interference with probiotic bacteria to support the stability and diversity of oral biofilms has gained similar interest. Investigations in vitro into metabolic activity, co-aggregation, growth inhibition, bacteriocin production, and adhesion have collectively suggested a potential role for probiotic lactobacilli and bifidobacteria to modulate the oral microbial ecology. Likewise, short-term clinical studies with intermediate microbial endpoints indicate that interference with caries-associated bacteria seems possible through probiotic dairy products, tablets, lozenges and chewing gum in various dose regimens. Few randomized controlled clinical trials with caries outcomes are available, but three studies with preschool children and the elderly have demonstrated preventive fractions between 21% and 75%, following regular intake of milk supplemented with probiotic lactobacilli. However, further large-scale trials with orally derived anti-caries candidates are needed before we can say that we are ready for bacteriotherapy as an adjunct to complement the existing evidence-based methods for preventing and controlling caries in daily practice.

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Section: Clinical Trials With Microbial Endpointsmentioning

confidence: 99%

Are we ready for caries prevention through bacteriotherapy?

Twetman

2012

Braz. oral res.

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“…Lozenges containing L. brevis CD2 taken by school children with a high caries risk, resulted in a reduction in plaque acidogenicity, salivary mutans-streptococci and bleeding on probing [69]. L. reuteri significantly inhibited the growth of S. mutans, if applied as yoghurt [70], via straws and tablets [71,72] or as chewing gum [73]. A combination of L. sporogens, L. bifidum, L. bulgaricus, L. thermophilus, L. acidophilus, L. casei and L. rhamnosus either as capsule or as liquid form was tested.…”

Section: Thereforementioning

confidence: 99%

Lactobacilli for the Treatment of Oral Diseases

Hoffmann¹,

Daniels²

2017

J Prob Health

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Probiotics are defined as live microorganisms that beneficially affect the host. Probiotic bacteria have been used therapeutically for years to target gastrointestinal disease by rebalancing the complex microflora. Besides the gastrointestinal tract also the oral cavity is highly colonized by bacteria and many different bacterial species are part of the microbiota in the mouth, as it offers ideal conditions for bacteria with a stable temperature, moist surface with a relatively stable pH and regular supply of nutrients. By disturbing the balance of microorganisms in the oral cavity or by extensive accumulation of plaque, the ratio of pathogenic organisms can increase and lead to oral health problems. Probiotic bacteria, like lactobacilli, are a promising treatment strategy for oral diseases with a microbiological aetiology. Those include plaqueassociated diseases like dental caries, which is an infectious disease with microbial processes eroding and destroying the hard dental tissue or inflammation of periodontal tissue, namely gingivitis and the more severe periodontitis. Moreover, endodontic infections, and even fungal, viral and acute bacterial infections could be treated by a probiotic therapy. The interest of probiotics in the field of oral health is growing, although it is still in its infancy. The present review adresses criteria for the selection of probiotic lactobacilli strains. It encompasses existing evidence on the use of lactobacilli for caries, halitosis and candidiasis, as well as for periodontal disease like Gingivitis and periodontitis.

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“…Inclusion of Lactobacillus rhamnosus GG and L. rhamnosus LC 705 in milk or processed cheese lowers salivary counts of S. mutans and reduces the incidence of dental caries in children 37 . Lactobacillus reuteri as probiotic in fluid or tablet form, chewing gum 38 or lozenge 39,40 , or as administered in yoghurt 41 has been found to decrease S mutans level in saliva. L. reuteri secretes two bacteriocins, reuterin and reutericyclin, that inhibits the growth of a wide variety of pathogens.…”

Section: Probiotics Applications In Dentistry Dental Cariesmentioning

confidence: 99%