A Prognostic Factor Study of Disease-Free Interval and Survival Following Enucleation for Uveal Melanoma

Seddon, Johanna M.; Albert, Daniel M.; Lavin, Philip T.; Robinson, Nancy

doi:10.1001/archopht.1983.01040020896012

Cited by 269 publications

(125 citation statements)

References 17 publications

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“…A low BECN1 expression, probably representing gene silencing mechanism in a subset of tumor, was also linked with death events but these were of delayed metastasis. Uveal melanomas with the presence of an epithelioid component showed a clear tendency for metastases and a reduced overall survival, but this has been known for long 56 and needs no further comment. It will be of interest to investigate in the future the relation of autophagy with tumorinfiltrating macrophages in uveal melanomas.…”

Section: Discussionmentioning

confidence: 44%

Autophagy patterns and prognosis in uveal melanomas

et al. 2011

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Autophagy is a self-degradation mechanism by which cells recycle their own cytoplasmic constituents. It has been claimed that, under certain conditions, such a process may be associated with tumor progression. In this study, the autophagic activity was investigated in a series of 99 uveal melanomas after immunohistochemical staining for the autophagy-associated proteins MAP1LC3A and BECN1, most commonly known as LC3A and Beclin 1, respectively. These were assessed in parallel with the hypoxia-inducible factor 1a (HIF1A) and its downstream protein lactate dehydrogenase 5 (composed by five LDHA subunits). Increased autophagic reactivity, detected by MAP1LC3A or BECN1, was associated with intense pigmentation and tumor hypoxia. Uveal melanomas with extensive overexpression of BECN1 or those with underexpression of this protein were associated with the worst prognosis, but the former manifested metastases much earlier than the latter; only 58% of patients with extensive BECN1 overexpression were alive at 4 years, compared with 80% of patients with underexpressed patterns. It is concluded that autophagy is commonly upregulated in uveal melanomas, and may be associated with hypoxia and intense pigmentation. There is a strong association between extensive BECN1 overexpression and early metastases/poor prognosis, and between underexpression of this protein and late metastases/better prognosis.

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Section: Discussionmentioning

confidence: 44%

Autophagy patterns and prognosis in uveal melanomas

et al. 2011

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“…Accurate predictive testing may allow systemic prophylaxis in high-risk patients. However, it is difficult to predict clinical outcome in individual melanoma patients because of the spectrum of clinical, morphologic, and cytologic changes and a lack of discrete stages (1,2). In uveal melanoma, alterations on chromosomes 3, 6, and 8q have been linked to metastatic death (3,4), but the clinical use of these findings has not been established.…”

Section: Introductionmentioning

confidence: 39%

Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic Death

et al. 2004

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Melanomas are notoriously difficult to classify because of a lack of discrete clinical and pathological stages. Here, we show that primary uveal melanomas surprisingly cluster into two distinct molecular classes based on gene expression profile. Genes that discriminate class 1 (low-grade) from class 2 (high-grade) include highly significant clusters of downregulated genes on chromosome 3 and up-regulated genes on chromosome 8q, which is consistent with previous cytogenetic studies. A three-gene signature allows biopsy-size tumor samples to be assigned accurately to tumor classes using either array or PCR platforms. Most importantly, this molecular classification strongly predicts metastatic death and outperforms other clinical and pathological prognostic indicators. These studies offer new insights into melanoma pathogenesis, and they provide a practical foundation for effective clinical predictive testing.

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“…Factors that may predict a poor prognosis include: tumour size (13)(14)(15) , old age (16) , tumour thickness (17) , and involvement of the ciliary body (18) . It is believed that a small, light CM takes 7 years to grow and another 4 years to develop metastases (12,18,19) .…”

Section: Discussionmentioning

confidence: 46%

Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

Pasetto¹,

Freitas²,

Colossi³

et al. 2013

Rev. bras.oftalmol.

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RESUMOObjetivo: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. Métodos: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. Resultados: De um total de 18 olhos, 7 (38.9%) foram incluídos no estudo. Cinco (71,4%) pacientes foram tratados exclusivamente com termoterapia transpupilar, em 1 (14,2%) olho a crioterapia foi simultânea, 1 (14,2%) suplementou braquiterapia -placa episcleral. Três (42.8%) sofreram recorrência, 2 (28.5%) apresentaram metástases (um óbito), 2 foram enucleados. Complicações foram encontradas em 3 olhos: dobras maculares em 2, hemorragia vítrea em 1. Nos olhos enucleados, não havia extensão extraescleral, porém células interesclerais foram identificadas. Conclusão: Termoterapia transpupilar mostra um declínio em sua eficácia e conserva os riscos de metástases em períodos mais longos de acompanhamento, sendo necessária uma definição mais exata de seu papel nos melanomas de coróide.

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A Prognostic Factor Study of Disease-Free Interval and Survival Following Enucleation for Uveal Melanoma

Cited by 269 publications

References 17 publications

Autophagy patterns and prognosis in uveal melanomas

Autophagy patterns and prognosis in uveal melanomas

Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic Death

Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

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