A Progressive Case of Lymphocytic Hypophysitis Accompanied by Paresis of the Left Abducens Nerve

Kageyama, Kazunori; Naraoka, Maki; Sakihara, Satoru; Ikeda, Hidetoshi; Sendo, Toshiaki; Suda, Toshio

doi:10.2169/internalmedicine.47.0952

Intern. Med.

2008

DOI: 10.2169/internalmedicine.47.0952

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A Progressive Case of Lymphocytic Hypophysitis Accompanied by Paresis of the Left Abducens Nerve

Kazunori Kageyama

Maki Naraoka

Satoru Sakihara

et al.

Abstract: Abstract

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Cited by 2 publications

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“…Histologically, LH is characterized by massive infiltration of the pituitary gland by lymphocytes and plasma cells. 9 Rituximab (Rituxan, Genentech, Inc.) is a monoclonal antibody against CD20 that selectively induces apoptosis in B lymphocytes. It is approved for various immune-mediated disorders, including B-cell non-Hodgkin lymphoma, CD20-positive chronic lymphocytic leukemia, rheumatoid arthritis, Wegener granulomatosis, and microscopic polyangiitis.…”

mentioning

confidence: 99%

Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab

Schreckinger¹,

Francis²,

Rajah³

et al. 2012

JNS

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Lymphocytic hypophysitis is an uncommon autoimmune condition that often results in significant morbidity. Although most cases resolve spontaneously or after a short course of steroids, rarely, refractory cases can cause persistent neurological deficits despite aggressive medical and surgical management. A 41-year-old woman presented with progressive visual loss in the left eye and was found to have a sellar mass. She underwent transsphenoidal surgery because of lesion enlargement. Histopathology was consistent with adenohypophysitis with B-cell predominance. Despite steroid treatment, her neurological condition worsened and she experienced loss of vision in the right eye. Craniotomy with decompression of the right optic nerve was performed. Her condition improved initially, but she continued to have progressive visual compromise over the following months. She was therefore treated with rituximab, a monoclonal antibody against B cells. Her vision improved significantly within a few weeks. There was no clinical or radiographic exacerbation 2 years after starting immunotherapy. Rituximab, an anti-CD20 antibody that specifically depletes B lymphocytes, can be an effective treatment strategy for patients with steroid-refractory, B cell-predominant lymphocytic hypophysitis.

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mentioning

confidence: 99%

Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab

Schreckinger¹,

Francis²,

Rajah³

et al. 2012

JNS

View full text Add to dashboard Cite

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Complete and Uneventful Recovery in a Case of Lymphocytic Hypophysitis Causing a Third Nerve Palsy

Nord

Shah

Verma

2022

Neuro-Ophthalmology

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A Progressive Case of Lymphocytic Hypophysitis Accompanied by Paresis of the Left Abducens Nerve

Abstract: Abstract

Cited by 2 publications

References 26 publications

Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab

Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab

Complete and Uneventful Recovery in a Case of Lymphocytic Hypophysitis Causing a Third Nerve Palsy

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