A Promising Antibacterial Wound Dressing Made of Electrospun Poly (Glycerol Sebacate) (PGS)/Gelatin with Local Delivery of Ascorbic Acid and Pantothenic Acid

Kermani, Paria Khaloo; Kharazi, Anousheh Zargar

doi:10.1007/s10924-022-02715-8

Cited by 8 publications

(4 citation statements)

References 62 publications

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“…Wound dressings with antibacterial activity at the wound site are preferred to prevent their attraction to the wound side and infections. As a result, the potential of hydrogels to suppress bacterial growth was evaluated by adding and controlling the release of antibacterial medications and agents 63,64 . Figure 4A,B presented the antibacterial properties of CMC/PEG and CMC/PEG containing Cur/Br, against both S. aureus and E. coli bacteria using the zone‐inhibition approach.…”

Section: Resultsmentioning

confidence: 99%

“…As a result, the potential of hydrogels to suppress bacterial growth was evaluated by adding and controlling the release of antibacterial medications and agents. 63,64 Figure 4A,B presented the antibacterial properties of CMC/PEG and CMC/PEG containing Cur/Br, against both S. aureus and E. coli bacteria using the zone-inhibition approach. It was observed that CMC/PEG-Cur/Br samples showed a superposition effect against both bacteria strains, and the inhibition zone against E. coli and S. aureus was 35 mm and 26 mm, respectively.…”

Section: Evaluation Of Antibacterial Propertiesmentioning

confidence: 99%

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Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Mojahedi,

Zargar Kharazi,

Poorazizi

2024

Polymer Engineering & Sci

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In this study, a wound‐healing membrane was fabricated based on carboxymethyl cellulose (CMC) and polyethylene glycol (PEG) containing curcumin (Cur) and bromelain (Br). Citric acid (CA) was used as a cross‐linking agent. This membrane showed an ideal degree of swelling, which was significantly dependent on the concentration and duration of cross‐linked CA. The chemical characterization showed the CA cross‐linker mechanism was more associated with chemical reactions with CMC carboxyl groups, and PEG hydroxyl groups played an important role in forming a hybrid polymer network. It greatly enhanced mechanical and adhesive properties, so the stress strength was improved from 29.4 to 38.52 Mpa. The hydrophilicity of the membrane surface according to the water contact angle assay showed the membrane surface is suitable for adhesion, growth, migration, and proliferation of skin cells. The drug delivery assay demonstrated that the Br and Cur were released during 48 h, but the Br followed the burst release in comparison with Cur. Antibacterial properties showed that CMC/PEG‐Cur/Br have ideal antibacterial properties for preventing the growth of bacteria. In summary, the engineered CMC/PEG containing Cur/Br films with desired cell viability properties and antibacterial activity can potentially improve and accelerate skin regeneration for chronic wound healing.Highlights Hydrogel film was prepared based on carboxymethyl cellulose (CMC), polyethylene glycol (PEG), and citric acid as cross‐linking agent. CMC/PEG film were induced controlling curcumin (Cur) and bromelain (Br) release for wound healing process. CMC/PEG film revealed a wide range of physiochemical, mechanical, adhesion, and biological properties behavior. Incorporation of Cur and Br promoted in vitro biocompatibility, L‐929 cells attachments, and cell migration.

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Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of Antibacterial Propertiesmentioning

confidence: 99%

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Mojahedi,

Zargar Kharazi,

Poorazizi

2024

Polymer Engineering & Sci

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“…This enhancement renders the PGS scaffold a more favorable biomaterial for skin TE applications. In another research, Kermani et al 215 developed a PGS/Gelatin wound dressing containing vitamins B5 and C through electrospinning. The degradation analysis revealed that approximately 20% of the cross-linked PGS-G/Vit B5/Vit C composite degraded over 14 days, while still maintaining satisfactory stability.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Harnessing the power of polyol-based polyesters for biomedical innovations: synthesis, properties, and biodegradation

Fakhri,

Su,

Tavakoli Dare

et al. 2023

J. Mater. Chem. B

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“…It is a biocompatible, elastic, and biodegradable polyester, and its degradation products can be removed by the body's metabolism. However, this polymer does not have an ideal hydrophilicity and degradation rate and cannot form a nanofibrous structure due to its low spinnability [21][22][23]. Thus, it should be blended with hydrophilic polymers.…”

Section: Introductionmentioning

confidence: 99%

PGS/Gelatin Nanocomposite Electrospun Wound Dressing

Naseri,

Hedayatnazari,

Tayebi

2023

J. Compos. Sci.

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Infectious diabetic wounds can result in severe injuries or even death. Biocompatible wound dressings offer one of the best ways to treat these wounds, but creating a dressing with a suitable hydrophilicity and biodegradation rate can be challenging. To address this issue, we used the electrospinning method to create a wound dressing composed of poly(glycerol sebacate) (PGS) and gelatin (Gel). We dissolved the PGS and Gel in acetic acid (75 v/v%) and added EDC/NHS solution as a crosslinking agent. Our measurements revealed that the scaffolds’ fiber diameter ranged from 180.2 to 370.6 nm, and all the scaffolds had porosity percentages above 70%, making them suitable for wound healing applications. Additionally, we observed a significant decrease (p < 0.05) in the contact angle from 110.8° ± 4.3° for PGS to 54.9° ± 2.1° for PGS/Gel scaffolds, indicating an improvement in hydrophilicity of the blend scaffold. Furthermore, our cell viability evaluations demonstrated a significant increase (p < 0.05) in cultured cell growth and proliferation on the scaffolds during the culture time. Our findings suggest that the PGS/Gel scaffold has potential for wound healing applications.

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A Promising Antibacterial Wound Dressing Made of Electrospun Poly (Glycerol Sebacate) (PGS)/Gelatin with Local Delivery of Ascorbic Acid and Pantothenic Acid

Cited by 8 publications

References 62 publications

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Harnessing the power of polyol-based polyesters for biomedical innovations: synthesis, properties, and biodegradation

PGS/Gelatin Nanocomposite Electrospun Wound Dressing

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