A promising technology for wound healing; <i>in-vitro</i> and <i>in-vivo</i> evaluation of chitosan nano-biocomposite films containing gentamicin

Asgarirad, Hossein; Ebrahimnejad, Pedram; Mahjoub, Mohammad Ali; Jalalian, Mohammad; Morad, Hamed; Ataee, Ramin; Hosseini, Seyyedeh Saba; Farmoudeh, Ali

doi:10.1080/02652048.2020.1851789

Cited by 18 publications

(12 citation statements)

References 38 publications

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“…Nanocomposites can be strengthened by adding particles and fibers to their matrix. The type and amount of the superficial interactions between the matrix and particles have a considerable effect on the different features of nanocomposites such as chemo-physical, optical, electrical, and mechanical properties [7]. There are four types of nanocomposites based on matrix substances: polymer matrix, ceramic matrix, metal matrix, and intermetallic matrix nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

Improving Antibacterial Efficiency of Curcumin in Magnetic Polymeric Nanocomposites

et al. 2022

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In recent years, resistance to chemical antibiotics, as well as their side effects, has caused a necessity to utilize natural substances and herbal components with antibacterial effects. Curcumin, the major substance of Curcuma longa’s rhizome, was used as an antibacterial agent since ancient times. This work aimed to formulate a novel nanocomposite for the delivery of curcumin to overcome orthodox drugs resistance against bacteria and improve its efficacy. To fabricate targeting nanocomposites, first, Fe3O4 nanoparticles were synthesized followed by coating the obtained nanoparticles using sodium alginate containing curcumin. A 2 by 3 factorial design was tailored to predict the optimum formulation of nanocomposites. Characterization of nanocomposites including particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and drug loading was performed. The optimum formulation was analyzed by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), Fourier-transformed infrared spectroscopy (FT-IR), and in vitro release study at different pHs. Finally, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of samples against seven common bacteria were determined. Results showed that the optimized formulation contained 400 nm particles with the PDI and zeta potentials of 0.4 and − 58 mV, respectively. The optimized formulation with 70% entrapment efficiency reduced the MIC value 2 to 4 times in comparison with pure curcumin. Results also showed that polymer and drug concentrations can significantly affect entrapment efficiency. In conclusion, the current investigation demonstrated that this magnetic nanocomposite can be applied for the delivery of curcumin. Graphical abstract

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Section: Introductionmentioning

confidence: 99%

Improving Antibacterial Efficiency of Curcumin in Magnetic Polymeric Nanocomposites

et al. 2022

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“…7(a)-6(f). In this staining, the blue color presented the relative amount of deposited total collagen and revealed the synthesis process of collagen (Asgarirad et al 2021). As shown in Fig.…”

Section: In Vivo Wound Healingmentioning

confidence: 88%

A handy skin wound dressing prepared by alginate and cationic nanofibrillated cellulose derived from solid residues of herbs

Jiang

Feng

et al. 2021

BioRes

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Large amounts of solid residues are generated after extraction of active ingredients from herbs for the production of natural medicine, but the residues have not been well utilized. In this work, cationic nanofibrillated cellulose (CCNF) was prepared from the solid residues of Astragali Radix by etherification and homogenization. The CCNF was mixed with sodium alginate (SA) to create a hydrogel dressing by physical interactions between CCNF and SA without any addition of cross-linker. The CCNF-SA dressing exhibited moderate viscosity, good moisture-maintaining property, great antibacterial activities, good cytocompatibility, and clear acceleration of wound healing on rats. Furthermore, this CCNF-SA dressing with nanofibrous structure had moderate air permeability. Therefore, the CCNF-SA hydrogel could be used potentially as a skin wound dressing. Development of cost-effective and bioactive wound dressing materials is of crucial importance to reduce the burden on patients and healthcare systems. Also, this work provides a new strategy for valorization of the solid residues of herbs.

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“…Chitosan (deacetylated chitin) is another natural polymer with unique biological activities such as the ability to prevent viral infection in plants and animal cells and even inhibition of phage infection in infected microbial cultures. This polymer has also been widely used as a promising carrier in drug delivery [ 188 , 189 ]. Amending the natural chemical characteristics of the chitosan molecule and modification of its physicochemical properties including the positive charge, the mean polymerization degree, and the degree of N-deacetylation have a strong impact on its antiviral activity.…”

Section: Polymers With Intrinsic Antiviral Propertymentioning

confidence: 99%

A Novel Vision of Reinforcing Nanofibrous Masks with Metal Nanoparticles: Antiviral Mechanisms Investigation

et al. 2023

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Prevention of spreading viral respiratory disease, especially in case of a pandemic such as coronavirus disease of 2019 (COVID-19), has been proved impossible without considering obligatory face mask-wearing protocols for both healthy and contaminated populations. The widespread application of face masks for long hours and almost everywhere increases the risks of bacterial growth in the warm and humid environment inside the mask. On the other hand, in the absence of antiviral agents on the surface of the mask, the virus may have a chance to stay alive and be carried to different places or even put the wearers at risk of contamination when touching or disposing the masks. In this article, the antiviral activity and mechanism of action of some of the potent metal and metal oxide nanoparticles in the role of promising virucidal agents have been reviewed, and incorporation of them in an electrospun nanofibrous structure has been considered an applicable method for the fabrication of innovative respiratory protecting materials with upgraded safety levels. Graphical Abstract

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A promising technology for wound healing; in-vitro and in-vivo evaluation of chitosan nano-biocomposite films containing gentamicin

Cited by 18 publications

References 38 publications

Improving Antibacterial Efficiency of Curcumin in Magnetic Polymeric Nanocomposites

Improving Antibacterial Efficiency of Curcumin in Magnetic Polymeric Nanocomposites

A handy skin wound dressing prepared by alginate and cationic nanofibrillated cellulose derived from solid residues of herbs

A Novel Vision of Reinforcing Nanofibrous Masks with Metal Nanoparticles: Antiviral Mechanisms Investigation

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