A Propos De L'Effet Des Rayons De Roentgen, Des Rayons γ, Et Des Rayons β Sur La Cellule Epidermique

Jadassohn, W.; Bujard, E; Paillard, R; Wenger, Paul Eugène Etienne; Gaudin, P.

doi:10.3109/00016925009135296

Cited by 8 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The volutiietric changes occurring in irradiated epithelia have been previouslyrelated to a marked aqueous inhibition of the keratinocytes (Jadassohn et al 1950, de Rey & Klein-Szanto 1972, de Rey & Cabritii 1973, Liu et al 1976. Recent quantitative studies of enzymes, protein, nucleic acids and sulfhydryl groups (KJein-Szanto & Cabrini 1970, Klein-Szanto et al 1974, Frasch et al 1976) and stereologic analysis of epidermal organelle composition (de Rey et al 1976) have detnonstrated that the lethally or sublethally irradiated keratinoeyte is capable of tnarkedly increasing its metabolic activity as well as the nutnber and volutne of itnportant cytoplasmic organelles.…”

Section: Discussionmentioning

confidence: 99%

Volumetric Modifications of X‐Irradiated Keratinocytes

1977

View full text Add to dashboard Cite

The number of epithelial cells per unit volume of tissue (NV) and the relative volume (VV) occupied by the spinous and basal layers of X-irradiated and non-irradiated rat-tail epidermis were studied using techniques of stereologic cytology. By a simple calculation, the absolute volumes of basal and spinous keratinocytes were determined in irradiated (and in non-irradiated, control) epidermis, 24, 48, 72 and 96 h after exposure to a single dose of 16 Krads. During this post-irradiation period, the absolute volumetric values of both basal and spinous keratinocytes increased gradually, reaching a three-fold increase 96 h after irradiation. At the same time, the relative volume of the spinous layer increased from 58% to 75% of the total epidermis, whereas the volume fraction occupied by the basal layer decreased from 20% to 16%. These findings support previous evidence that lethally and sublethally damaged keratinocytes are capable of a metabolic effort resulting in a cell hypertrophy which in some circumstances could lead to repair and recovery from radiation damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Volumetric Modifications of X‐Irradiated Keratinocytes

1977

View full text Add to dashboard Cite

show abstract

“…P a r des ex p érien ces a n té rie u res, nous savons q u 'une dose de 400 r donnée p a r 70 K v ., 5 m A ., d ista n c e de 24 cm , filtre de 0,5 m m Al. dim in u e fo rte m e n t la réactio n de D u stin au niv eau de l'ép iderm e de la té tin e d u co b ay e m âle m ise en p ro lifératio n p a r l'H o rm oestrol (8). N ous av o n s re p ris c e tte dose de 400 r p o u r ju g e r de l'effet des ray o n s X su r la ré a c tio n de D u stin au n iv eau de la glan d e m am m aire, m ais nous av o n s f a it v a rie r le kilovoltage e t le filtre.…”

Section: ° Durée D'action De Vhormoestrol Sur La Glande M Am M Aireunclassified

“…nous sav o n s q u e c e tte dose ne d o n n e q u 'irrég u lièrem en t une d im in u tio n d u n o m b re des m itoses au n iv eau de l'ép id erm e de la té tin e (8). N ous p o u v o n s tir e r de ces ré s u lta ts u n e a u tre conclusion: les m ito ses de la g lan d e m am m aire sem b lent av oir la m êm e sensibilité aux ra y o n s X q u e les m itoses de l'ép id erm e puisq u e les deu x genres de m ito se so n t fo rte m e n t dim inués avec 400 r et ne le so n t que p a rtie lle m e n t avec 200 r.…”

Section: ° Durée D'action De Vhormoestrol Sur La Glande M Am M Aireunclassified

La glande mammaire du cobaye et son emploi comme organe-test en radiothérapie dermatologique

Golay¹

1958

Dermatology

View full text Add to dashboard Cite

“…Greater effectiveness ratios, based on mean survival time of mice after supralethal irradiation, have been reported (20); it is not clear, however, whether the dose rates for 'Y-and x-rays were com parable. It is curious, moreover, that mice were killed by total-body doses as small as 100 r. Differences in biological efficiency are not always apparent in this region of ionization density (21,22) and, in fact, fast electrons may be more effective in certain instances (23).…”

mentioning

confidence: 99%

Radiation Effects on Mammalian Systems

Patt¹

1954

Annu. Rev. Physiol.

View full text Add to dashboard Cite

This review will be concerned with the acute effects of high energy radia tions on mammalian systems. Its purpose is twofold; to delineate many of the recent papers in this areal and to place the more important contributions in some perspective to the over-all physiology of radiation injury. Complete coverage of radiation effects is not intended, owing to the vast literature and the consequent necessity of excluding many papers to conform to the allotted space.3 Several surveys of the more general aspects of radiation effects on liv ing systems have been presented recently (1 to 7); cellular (8, 9), embryo logiCal (10), and carcinogenic (11) actions of irradiation have also been cov ered. The extensive report of acute radiation injury in man resulting from accidental nuclear reactions should be consulted (12). These cases represent radiation injury not complicated by the effects of heat and blast.It is appropriate to say a word about trends in mammalian radiobiology by way of introduction. We may note an increasing interest in the more im mediate physical and chemical changes in irradiated tissue. Such endeavors have been greatly influenced by present concepts of the modes of energy transfer and the recognition that certain, apparently primary, events may be modified experimentally. Greatest attention continues to be focused, how ever, on the disordered physiology as manifested by effects on growing and developing systems generally and by pancytopenia, bleeding, inanition, in fection, altered immune reactions, and carcinogenesis, specifically. In this area, there is a growing awareness that injury and recovery may be influenced to a considerable extent by the physiological interplay in the organism as a whole.THE RADIATIONS While all of the ionizing radiations produce more or less similar biological effects, their efficiency can vary considerably, This depends apparently upon the energy absorption in space and time and also upon its distribution within the organism. For most effects, excluding those that are related pre sumably to very small volumes, biological effectiveness increases with in crease in linear ion density or, more appropriately, in linear energy transfer. Gray (13) has emphasized that the rapid variation of efficiency with ion 1 The survey of literature pertaining to this review covers the period from January, 1951 to June, 1953.2 The following abbreviations are used in this chapter: DNA (desoxyribonucleic acid); RNA (ribonucleic acid).3 This refers in particular to miscellaneous effects on skin, bone, gonads, and nervous system. 51Annu. Rev. Physiol. 1954.16:51-80. Downloaded from www.annualreviews.org by University of Laval on 07/11/14. For personal use only.Quick links to online content Further ANNUAL REVIEWS

show abstract

A Propos De L'Effet Des Rayons De Roentgen, Des Rayons γ, Et Des Rayons β Sur La Cellule Epidermique

Cited by 8 publications

References 0 publications

Volumetric Modifications of X‐Irradiated Keratinocytes

Volumetric Modifications of X‐Irradiated Keratinocytes

La glande mammaire du cobaye et son emploi comme organe-test en radiothérapie dermatologique

Radiation Effects on Mammalian Systems

Contact Info

Product

Resources

About