A Proposal for Naming Adenovirus Genome Types, Exemplified by Adenovirus Type 6

Abstract

SUMMARYA numerical code to denominate adenovirus (AV) genome types is proposed. Seven restriction endonuclease patterns are listed in alphabetical order (BamHI, BglII, BstEII, EcoRI, HindIII, KpnI, Sinai); patterns deviating from those of the prototype (1) are named 2, 3 etc. depending on the chronological order of the respective isolates. Thus AV6/3 : 12 31121 is a type 6 strain deviating from the prototype in three patterns, i.e. those of BgllI, BstEII and KpnI. From 24 AV6 isolates, six were identical with the prototype, whereas the other strains represented 13 different genome types.

Molecular Epidemiology of Adenovirus Isolates from Patients Diagnosed with Intussusception in Melbourne, Australia

“…In this study, characterization of species C isolates into serotypes identified types AdV-1, AdV-2, and AdV-5 in both IS and non-IS cases, with no significant differences identified between the groups. AdV-6 was absent as also noted in other studies (2,3).…”

“…Interestingly, five of six genetic types identified were present in ISassociated strains, while only three types were present in the non-IS-associated strains. This large genetic diversity is supported by previous analysis of species C serotypes in non-ISassociated isolates (1,2). Despite this strain diversity, D2 was shown to be the dominant genome type in both IS-and non-IS-associated adenovirus isolates.…”

“…DNA was digested individually with BamHI and SmaI (New England BioLabs, MA), and restriction patterns were assigned according to the system proposed by Adrian et al (2,3).…”

Human Adenovirus from Subgenus D: Restriction Mapping of Types 9 and 19 and Characterization of a New Genome Type

“…For example, a comparison between 24 AV6 isolates and the AV6 prototype has revealed percentages of comigration between 65 ~ and 100 ~ (Adrian et al, 1985b). Between two different AV species from subgenus D, have found percentages of comigration between 38 ~o and 79 ~.…”

Persistent enteral infections with adenovirus types 1 and 2 in infants: no evidence of reinfection

“…To decide between these two possibilities, viruses isolated early and late after infection were compared by DNA restriction analysis. In this context it is advantageous that adenoviruses of subgenus C (types 1, 2, 5, 6) display a high degree of genetic variability (Adrian, Best & Wigand, 1985; Fig. 3.…”