A Prospective Cohort Study Evaluating the Transplacental Transmission of Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Pregnant Women and Their Offspring: The Study Design and Demographic Description

Ley, Sylvia H.; Li, Y.; Piedimonte, Giovanni

doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1775

A52. Pediatric Lung Infections 2022

DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1775

|View full text |Cite

A Prospective Cohort Study Evaluating the Transplacental Transmission of Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Pregnant Women and Their Offspring: The Study Design and Demographic Description

Sylvia H. Ley

Y. Li

Giovanni Piedimonte

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To address these questions, we began a multisite prospective cohort study of 105 dyads, each comprising a pregnant woman delivering a full-term newborn between 2020 and 2022 in greater New Orleans, Louisiana, including clinical outcomes recorded in the perinatal period (e.g., weight, length of hospital stay). Some of the results of these studies have been previously reported in abstract form ( 4 , 5 ).…”

mentioning

confidence: 91%

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Trinh,

Desai,

Ley

et al. 2024

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale Respiratory viral infections can be transmitted from pregnant women to their offspring, but frequency, mechanisms, and postnatal outcomes remain unclear. Objectives The aims of this prospective cohort study were to compare the frequencies of transplacental transmission of respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), analyze the concentrations of inflammatory mediators in maternal and fetal blood, and assess clinical consequences. Methods We recruited pregnant women who developed upper respiratory infections or tested positive for SARS-CoV-2. Maternal and cord blood samples were collected at delivery. Study questionnaires and electronic medical records were used to document demographic and medical information. Measurements and Main Results From October 2020 to June 2022, droplet digital PCR was used to test blood mononuclear cells from 103 mother–baby dyads. Twice more newborns in our sample were vertically infected with RSV compared with SARS-CoV-2 (25.2% [26 of 103] vs. 11.9% [12 of 101]; P = 0.019). Multiplex ELISA measured significantly increased concentrations of several inflammatory cytokines and chemokines in maternal and cord blood from newborns, with evidence of viral exposure in utero compared with control dyads. Prenatal infection was associated with significantly lower birth weight and postnatal weight growth. Conclusions Data suggest a higher frequency of vertical transmission for RSV than SARS-CoV-2. Intrauterine exposure is associated with fetal inflammation driven by soluble inflammatory mediators, with expression profiles dependent on the virus type and affecting the rate of viral transmission. Virus-induced inflammation may have pathological consequences already in the first days of life, as shown by its effects on birth weight and postnatal weight growth.

show abstract

mentioning

confidence: 91%

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Trinh,

Desai,

Ley

et al. 2024

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A Prospective Cohort Study Evaluating the Transplacental Transmission of Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Pregnant Women and Their Offspring: The Study Design and Demographic Description

Cited by 1 publication

References 0 publications

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Contact Info

Product

Resources

About