A prospective cohort study investigating the peri- and postoperative outcomes following ovariohysterectomy in bitches neutered prepubertally or post-pubertally

Moxon, Rachel; Freeman, Sarah; Payne, Richard; Corr, Sandra A.

doi:10.1016/j.theriogenology.2022.11.047

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Interestingly, a dorsal vulval skin fold was apparent in almost all vulval images from bitches at both ages, and percentage cover of the skin fold was reported, which to the authors knowledge is the first time that this feature has been documented in such a large study population. Similar to findings relating to peri and postoperative outcomes [51], veterinary practice was one of the biggest and most consistent influencing factors for height, weight, BCS, and vulva size measurements.…”

Section: Discussionsupporting

confidence: 67%

“…Using a prospective cohort study design, 306 bitches born in an assistance dog programme between 22 February 2012 and 9 August 2015 were neutered either prepubertally or post-pubertally as previously described [51]. Data were gathered from bitches at sixand 17-months of age to examine their physical development.…”

Section: Methodsmentioning

confidence: 99%

“…Bitches were allocated into two groups: neutered prepubertally (at six-months of age: PPN, n = 155) or post-pubertally (after their first oestrus: control, n = 151). Bitches were from five different Labrador/Golden Retriever cross breeds [51]. All 306 bitches were available for physical assessments at six-months of age.…”

Section: Study Animalsmentioning

confidence: 99%

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A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development

Moxon

Freeman

Payne

et al. 2023

Animals

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No previous large prospective cohort studies have been identified that have investigated the impact of the surgical neutering of bitches before or after known puberty on their growth and physical development. This study was designed to examine the data on physical development, vulval size, and conformation for bitches neutered by ovariohysterectomy before puberty (PPN, n = 155) or after puberty (control, n = 151) using a prospective cohort study design. Data were gathered at 6- and 17-months of age using bespoke physical assessment forms and digital images of the vulva. PPN bitches had greater changes in height measurements (mean difference = 2.039, SEM = 0.334, 91% CI = 1.471 to 2.608, p < 0.001) and smaller changes in the measurements of vulval length (mean difference = −0.377, SEM = 0.079, 91% CI = −0.511 to −0.243, p < 0.001) and width (mean difference = −0.221, SEM = 0.063, 91% CI = −0.328 to −0.113, p < 0.001) between 6- and 17-months of age than for the control bitches. Although not significant, the PPN bitches were taller (mean 58.5 vs. 56.6 cm) and heavier (mean 28.3 vs. 27.3 kg) with smaller vulval size measurements (mean vulval length 2.8 vs. 3.2 cm, mean vulval width 1.7 vs. 2.1 cm) at 17-months of age. At 17-months of age, significantly more PPN bitches had vulvas that appeared juvenile (Yates’ Chi-square = 14.834, D.F. = 1, p < 0.001) and recessed (Yates’ Chi-square = 7.792, D.F. = 1, p = 0.005) at the physical assessment, and significantly more PPN bitches had vulvas that appeared ‘recessed/inverted’ on the examination of digital images (Chi-square = 9.902, D.F. = 1, p = 0.002). The results from this study suggest no contraindications to prepubertal ovariohysterectomy for large breed bitches. However, any longer-term health implications of these differences in physical development need to be investigated and better understood prior to recommendations being made.

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Section: Discussionsupporting

confidence: 67%

Section: Methodsmentioning

confidence: 99%

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A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development

Moxon

Freeman

Payne

et al. 2023

Animals

Self Cite

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“…For many years, surgical castration was the only reliable and permanent method of contraception in dogs. Ovariectomy, ovariohysterectomy (OHC) and orchidectomy are the most common surgical procedures routinely performed in small animal practice [1,2]. Prepubertal ovariectomy (or OHC) is defi ned as the surgical castration of immature female animals between 6 to 14 weeks of age, and it is often associated with some long-term behavior and health effects [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Use of Long-Term GnRH Agonist in Prepubertal Bitches: Effect on P4, E2 and Melatonin Serum Concentration before and During First Estrus

Daghistani,

Stanišić,

Đurić

et al. 2024

Acta Veterinaria

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The aim of this study was to determine the length of the contraceptive period after the application of deslorelin implant (4.7 mg) in juvenile, prepubertal bitches and assess the effects on the hormonal status (P4, E2 and melatonin), as well as on the occurrence of normal physiological estrus. Twelve crossbred prepubertal female dogs (4 months of age) were divided into the two groups, the treated group (DESLO) and control (placebo) group (C). Hormone assays, vaginal microbiological and cytological smears and the measurements of electrical resistance of cervical mucus were performed once in 3 weeks until the first signs of proestrus, and every day during estrus. GnRH implant significantly postponed time of onset of estrus (633 ± 30,38 days vs. 143.80 ± 52,30 days, P<0.001). In estrus, DESLO group showed statistically higher E2 (34.58 pg/mL vs. 20.59 pg/mL, P<0.001) and melatonin serum concentration (45.86 pg/mL vs. 18.85 pg/mL, P<0.001) compared to the control group. The average P4 serum concentration had no statistically significant differences between groups. In conclusion, deslorelin implants do not cause “flare up” effect in perpubertal bitches, however, increase of E2 and especially melatonin serum concentrations show the need to explore the consequences and mutual influence of melatonin and deslorelin implants in the future.

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Surgical Time for Laparoscopic Ovariectomy in Adult and Prepubertal Dogs

Tez

Kanca

ERGÜL

2023

Harran Üniversitesi Veteriner Fakültesi Dergisi

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Two-portal laparoscopic ovariectomy (LOVE) was performed in adult (n=23) and prepubertal dogs (n=23) to compare surgical time and to evaluate the effect of age, body weight (BW), body condition score (BCS), ovarian pedicle fat score (OPFS) and intraoperative surgical complications on surgical time. Three classes of BCS were considered: BCS 1-2=lean; BCS 3=ideal; BCS 4-5=overweight. All surgeries were performed by the same surgeon. OPF was scored and was considered negative or positive. Intraoperative complications were recorded. Total surgical time was recorded as time from the first skin incision to placement of the last portal closure suture. The surgical procedure was divided into 7 different stages and the time for each stage was recorded. Data are reported as mean±SEM. Differences in the duration of defined surgical stages between groups were evaluated by age, BW, OPFS and intraoperative complications. One-way analysis of variance was used to evaluate the effect of BCS. No major complications were observed. Five and 4 minor complications were observed in adult and prepubertal dogs, respectively. Total surgical time was not different (p>0.05) between adult (20.63±0.60 min) and prepubertal (21.48±1.75 min) dogs. BCS, BW and OPF did not affect total surgical time (p>0.05). Intraoperative complications prolonged surgical times (25.20±2.33 min vs 20.04±0.93 min). Time from first skin incision to insertion of first trocar was shorter (p

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A prospective cohort study investigating the peri- and postoperative outcomes following ovariohysterectomy in bitches neutered prepubertally or post-pubertally

Cited by 3 publications

References 21 publications

A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development

A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development

Clinical Use of Long-Term GnRH Agonist in Prepubertal Bitches: Effect on P4, E2 and Melatonin Serum Concentration before and During First Estrus

Surgical Time for Laparoscopic Ovariectomy in Adult and Prepubertal Dogs

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