A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

Risslegger, Brigitte; Zoran, Tamara; Lackner, Michaela; Aigner, Maria; Sánchez-Reus, Ferran; Rezusta, Antonio; Chowdhary, Anuradha; Taj-Aldeen, Saad J.; Arendrup, Maiken Cavling; Oliveri, Salvatore Massimo; Kontoyiannis, Dimitrios P.; Alastruey‐Izquierdo, Ana; Lagrou, Katrien; Cascio, Giuliana Lo; Meis, Jacques F.; Buzina, Walter; Farina, Claudio; Drogari‐Apiranthitou, Maria; Grancini, Anna; Tortorano, A.M.; Willinger, Birgit; Hamprecht, Axel; Johnson, Elizabeth; Klingspor, Lena; Arsić-Arsenijević, Valentina; Cornely, Oliver A.; Meletiadis, Joseph; Prammer, Wolfgang; Tullio, Viviana Cristina; Vehreschild, J. J.; Trovato, Laura; Lewis, Russell E.; Segal, Esther; Rath, Peter‐Michael; Hamal, Petr; Rodríguez-Iglesias, Manuel; Roilides, Emmanuel; Arıkan-Akdağlı, Sevtap; Chakrabarti, A.; Colombo, Arnaldo Lopes; Fernández, Mariana Soledad; Martín-Gómez, M Teresa; Badali, Hamid; Πετρίκκος, Γεώργιος; Климко, Н Н; Heimann, Sebastian; Houbraken, Jos; Uzun, Ömrüm; Edlinger, Michael; Fuente, Sonia de la; Lass‐Flörl, Cornelia

doi:10.1016/j.cmi.2017.04.012

Cited by 44 publications

(56 citation statements)

References 12 publications

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“…Interestingly, in our study, a large number of A. terreus sensu stricto isolates were found with low amphotericin B MICs. The data in the present study are in concordance with a study by Risslegger et al, who reported low amphotericin MICs (MIC range, 0.25‐0.5 μg/ml) in 6.3% A. terreus sensu stricto . Investigation of the impact of clinical, environmental and even ecological factors on various amphotericin B susceptibility profiles in different countries can be considered.…”

Section: Discussionsupporting

confidence: 93%

“…The variable methodologies employed in previously published studies, the failure of molecular identification and the emergence of cryptic species may be the main reasons associated with these differences. A prospective international A. terreus analysis with 370 cases from 21 countries showed low susceptibility to amphotericin B against the majority of cryptic species, the amphotericin B profiles of A. terreus on a worldwide scale is still poorly understood and more research is needed . Overall, in vitro susceptibility testing can help to select an appropriate therapy and to improve the management of patients infected with A. terreus .…”

Section: Discussionmentioning

confidence: 99%

“…terreus analysis with 370 cases from 21 countries showed low susceptibility to amphotericin B against the majority of cryptic species, the amphotericin B profiles of A. terreus on a worldwide scale is still poorly understood and more research is needed. 23 Overall, in vitro susceptibility testing can help to select an appropriate therapy and to improve the management of patients infected with A. terreus. Susceptibility trends of A. terreus in surveillance studies can aid this objective.…”

Section: Discussionmentioning

confidence: 99%

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In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex

Vaezi

Fakhim

Arastehfar

et al. 2017

Mycoses

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Aspergillus terreus infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other Aspergillus species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n = 36) and environmental (n = 45) A. terreus isolates. In vitro antifungal susceptibility was performed using the CLSI M38-A2 procedure. Amphotericin B exhibited the highest MICs (MIC range, 0.125-4 μg/mL; MIC , 2 μg/mL), followed by terbinafine (MIC range, 0.002-1 μg/mL; MIC , 1 μg/mL). Only one isolate (1/81) showed amphotericin B MIC above the epidemiologic cut-off value (ECV; 4 μg/mL). None of the isolates had a MIC of ≥ ECV for voriconazole, itraconazole and posaconazole. The reasons for the difference in amphotericin B susceptibility patterns between studies remain unknown. The genetic and species diversity, clinical, environmental and ecological factors in Terrei section on various amphotericin B susceptibility profiles in different countries should be considered more as the main reasons associated with these differences.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex

Vaezi

Fakhim

Arastehfar

et al. 2017

Mycoses

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“…Also at 30°C all species exhibited lower growth, although not statistically significant. The three clinically most common species [17,29] A. terreus s.s., A. citrinoterreus and A. hortai showed superior growth rates (statistically significant, p < 0.05) at temperatures relevant for human infection, 30°C (superficial infections) and 37°C (deep infections), when compared with other, less abundant species of the section Terrei. Compared to growth at 37°C and 42°C, standard deviation of colony diameters of cultures grown at 25°C is very low between the individual strains.…”

Section: Resultsmentioning

confidence: 99%

“…is geographically widespread, clusters with particularly high A. terreus infection incidences were reported from Innsbruck (Austria) and Houston (USA) [16]. Approximately 5.2% of all aspergillus infections are caused by Aspergillus terreus s.l [17].…”

Section: Introductionmentioning

confidence: 99%

Cryptic species of Aspergillus section Terrei display essential physiological features to cause infection and are similar in their virulence potential in Galleria mellonella

et al. 2019

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Aspergillus species account for the majority of invasive mold infections in immunocompromised patients. Most commonly, members of the Aspergillus section Fumigati are isolated from clinical material, followed by isolates belonging to section Terrei. The section Terrei contains 16 accepted species. Six species were found to be of clinical relevance and studied for differences in growth adaptability and virulence potential. Therefore, a set of 73 isolates (22 A. terreus s.s., 8 A. alabamensis, 27 A. citrinoterreus, 2 A. floccosus, 13 A. hortai, and 1 A. neoafricanus) was studied to determine differences in (a) germination kinetics, (b) temperature tolerance, (c) oxygen stress tolerance (1% O 2 ), and (d) a combination of the latter two. Virulence potential of phialidic (PC) and accessory conidia (AC) was studied in G. mellonella larvae, using survival as read out. Further, the formation of AC was evaluated in larval tissue. All isolates were able to grow at elevated temperature and hypoxia, with highest growth and germination rates at 37°C. A. terreus s.s., A. citrinoterreus, and A. hortai exhibited highest growth rates. Virulence potential in larvae was inoculum and temperature dependent. All species except A. floccosus formed AC and germination kinetics of AC was variable. Significantly higher virulence potential of AC was found for one A. hortai isolate. AC could be detected in larval tissue 96 h post infection. Based on these findings, cryptic species of section Terrei are well adapted to the host environment and have similar potential to cause infections. ARTICLE HISTORY

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Antifungal Agents

Lockhart,

Berkow

2023

ClinMicroNow

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This chapter summarizes the comparative activities of the major systemic antifungal agents against important groups of fungi. It discusses the characteristics of the several other agents that can be used for the oral or parenteral treatment of superficial, subcutaneous, or systemic fungal infections. The allylamines are a group of synthetic antifungal compounds effective in the topical and oral treatment of dermatophytoses. Terbinafine is a lipophilic drug that is available for oral or topical administration. With the exception of fluconazole and isavuconazole, food has a significant effect on the absorption of azole antifungals. Itraconazole is a lipophilic triazole drug available for oral or parenteral administration. Ketoconazole is a lipophilic drug formulated for oral or topical use. The echinocandins are semisynthetic lipopeptide antifungal agents that target the fungal cell wall. Micafungin is a water‐soluble antifungal agent, derived from a fermentation product of Coleophoma empetri .

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A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

Abstract: Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.

Cited by 44 publications

References 12 publications

In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex

In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex

Cryptic species of Aspergillus section Terrei display essential physiological features to cause infection and are similar in their virulence potential in Galleria mellonella

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