A Prospective, Longitudinal Study of the Functional Status and Quality of Life of Older Patients with Breast Cancer Receiving Adjuvant Chemotherapy

Hurria, Arti; Hurria, A.; Zuckerman, Enid; Panageas, Katherine S.; Fornier, Monica; D’Andrea, Gabriella; Dang, Chau T.; Moasser, Mark M.; Robson, Mark E.; Seidman, Andrew D.; Currie, Violante E.; Van-Poznak, C.; Theodoulou, Maria; Lachs, Mark S.; Hudis, Clifford A.

doi:10.1111/j.1532-5415.2006.00789.x

Cited by 90 publications

(53 citation statements)

References 53 publications

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“…will superimpose on the geriatric profile of the patient, thereby further compromising prognosis. It has been shown that CGA adds useful information to the evaluation of the World Health Organization-Eastern Cooperative Oncology Group performance status in older patients with cancer and is able to predict efficacy and tolerance of chemotherapy [14,19]. Geriatric instruments appear more sensitive than classic oncological instruments in measuring functional status [9].…”

Section: Geriatric Profilementioning

confidence: 99%

Nutritional assessment in geriatric cancer patients

Vandewoude

2009

Support Care Cancer

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Nutritional assessment should be part of the routine preliminary evaluation of the older oncology patient. Difference should be made between assessment of risk and actual nutritional status, which should be assessed with specific malnutrition indices. Body weight assessment with specific attention to unintended weight loss is essential in this evaluation. One should recognize the fact that body mass index (BMI) should be interpreted with caution, but that a low value for BMI still heralds an increased malnutrition risk. This increased alertness for nutritional problems has a lot to offer in the willingness for early intervention. The nutritional assessment, however, must be framed in a larger comprehensive geriatric assessment addressing several functional domains.

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Section: Geriatric Profilementioning

confidence: 99%

Nutritional assessment in geriatric cancer patients

Vandewoude

2009

Support Care Cancer

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“…An aspect where much less data is available is response and toxicity patterns of patients in intermediate condition that would not fit standard study inclusion criteria, or studies addressing the general population of oncology clinics. Two studies prospectively assessed such a population (18,42). One observed 60 patients with various cancers.…”

Section: Treatment Patterns and Tolerancementioning

confidence: 99%

“…Yet most were able to complete their treatment with little impact on their functional status (43). The other study focused on breast cancer patients (42). Here again, half of the patients experienced toxicity but were able to continue.…”

Section: Treatment Patterns and Tolerancementioning

confidence: 99%

Geriatric Oncology: An Overview of Progresses and Challenges

Extermann

2010

Cancer Res Treat

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I n t r o d u c t i o nThanks to the global improvement of health care and living conditions, the world population is aging. Already, in developed countries, half of the cancers occur in patients aged 70 and older. In booming Asian nations, such as South Korea, the aging trend is particularly striking, and therefore geriatric oncology is rapidly coming at the foreground of oncology practice. In this article, we plan to review the main acquisitions of this field over the last decades, as well as the areas of present critical research. C o n c e p t u a l F r a m e w o r k sThe notion of geriatric oncology was first articulated in the eighties by pioneers such as Rosemary Yancik, Paul Carbone and Jerry Yates (1). Some of the early studies, mostly retrospective reviews of study data, also started in the eighties (2,3). Over the last twenty years, the framework of the research has been mainly to define the characteristics of older cancer patients, analyze how they were tolerating cancer treatments, and how to best integrate geriatric tools and expertise (mostly the CGA) into cancer care.The following concepts are presently under very active investigation: -A two steps approach to the initial evaluation of older cancer patients is becoming the paradigm of choice. A short screening tool applied in the oncology practice, followed by a more comprehensive geriatric assessment and an integrated approach by a multidisciplinary team for those who screen positive. A range of short screening tools are becoming available for use (see below).-The integration of geriatric instruments as decision tools in the treatment of cancer. At this year's ASCO meeting, two scores for predicting toxicity from chemotherapy were presented (4,5). These Thanks to the global improvement of health care and living conditions, the world population is aging. Already, in developed countries half of the cancers occur in patients aged 70 and older. In booming Asian nations, such as South Korea, the aging trend is particularly striking, and therefore geriatric oncology is rapidly coming at the foreground of oncology practice. As older patients have a very variable health status, the need for proper integration of an oncologic and a geriatric approach has become increasingly clear. The last two decades have seen the development of geriatric oncology programs and research, which we review here. An increasing amount of data is making clear that a geriatric assessment identifies many problems in older people with cancer, adds prognostic information, and might improve the outcomes of these patients. The near future will likely deliver the following: Operationalization of geriatric assessment into assessment and decision tools, as well as multidisciplinary interventions, in oncology; cooperation of aging and cancer research in the understanding of cancer biology, aging physiology, pharmacology of anticancer drugs; improved clinical study designs; development of geriatric oncology programs, and screening tools accessible to the private practitioner.

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“…The possible impact of geriatric interventions on cancer outcome is unknown, even though some small prospective studies suggest positive effects. 19,20 Nowadays the concept of oncogeriatry is shared by all oncological and geriatric communities around the world. It is interesting to engage in a semantic discussion about the term: is it actually indicate that it is a sub-speciality of oncology (similar to gastrointestinal oncology), whereas 'oncogeriatry' indicates a merge between oncology and geriatrics.…”

Section: The Concept Of Oncogeriatrymentioning

confidence: 99%

Development of Oncogeriatry – A European Perspective from the French Experience

Terret¹,

Droz²

2009

European Oncology &Amp; Haematology

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Oncogeriatry is the clinical discipline concerned with the management of elderly cancer patients. It is based on a global oncological and geriatric approach to the health status of patients. Oncogeriatry has been widely adopted throughout the world, but the approaches used and the organisational solutions provided are complex and varied. Based on the French experience of a centralised health system, the different aspects are discussed: clinical management, organisation, clinical research and information. At a European level, the best approach seems to be a partnership between the International Society of Geriatric Oncology and the Elderly Task Force of the European Organisation on Research and Treatment of Cancer. This co-operation ensures comprehensive information on oncogeriatric programmes, clinical research and teaching programmes, thus enhancing the effectiveness of the oncogeriatric approach.

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A Prospective, Longitudinal Study of the Functional Status and Quality of Life of Older Patients with Breast Cancer Receiving Adjuvant Chemotherapy

Cited by 90 publications

References 53 publications

Nutritional assessment in geriatric cancer patients

Nutritional assessment in geriatric cancer patients

Geriatric Oncology: An Overview of Progresses and Challenges

Development of Oncogeriatry – A European Perspective from the French Experience

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