2019
DOI: 10.1136/ijgc-2018-000010
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A prospective multicenter trial on sentinel lymph node biopsy in patients with early-stage cervical cancer (SENTIX)

Abstract: ObjectiveSentinel lymph node (SLN) biopsy has been increasingly used in the management of early-stage cervical cancer. It appears in guidelines as an alternative option to systematic pelvic lymphadenectomy. The evidence about safety is, however, based mostly on retrospective studies, in which SLN was combined with systematic lymphadenectomy.Materials and methodsSENTIX is a prospective multicenter trial aiming to prove that less-radical surgery with SLN is non-inferior to treatment with systematic pelvic lympha… Show more

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Cited by 72 publications
(45 citation statements)
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“…This topic can be answered by currently ongoing prospective studies. 10,147,148 We believe that an ultrastaging protocol aimed at the detection of as many MICs and ITCs as possible should be favored over a more limited approach, until more data regarding their clinical significance are obtained. However, regarding the significance of ITCs, it would be difficult to gain data that would allow us to assess their prognostic meaning even from prospective trials.…”
Section: Discussionmentioning
confidence: 99%
“…This topic can be answered by currently ongoing prospective studies. 10,147,148 We believe that an ultrastaging protocol aimed at the detection of as many MICs and ITCs as possible should be favored over a more limited approach, until more data regarding their clinical significance are obtained. However, regarding the significance of ITCs, it would be difficult to gain data that would allow us to assess their prognostic meaning even from prospective trials.…”
Section: Discussionmentioning
confidence: 99%
“…PI-88 is in clinical trial for the treatment of liver cancer, non-small cell lung cancer, melanoma, and prostate cancer (). Similarly, CX-01 is currently in clinical trials for myeloid leukaemia and cervical cancer [42]. Thus, it is clear that these HS mimetics have the potential to treat human disease and have been shown to produce very few side effects.…”
Section: Discussionmentioning
confidence: 99%
“…In the latest FIGO staging system for cervical cancer, patients with lymphatic metastasis are classified as stage IIIC and should be treated with concurrent chemoradiotherapy [17]. The safety and benefits of omitting lymphadenectomy in SLN-negative patients remain to be determined in prospective trials (SENTIX = NCT02494063, CSEM010 = NCT02642471, SENTICOL III = NCT03386734) [18,19]. Yet, in many institutions, gynecologists have been accustomed to replacing lymphadenectomy with SLN biopsy and waiting for final pathology only.…”
Section: Discussionmentioning
confidence: 99%