A Prospective, Noninterventional Study of the Treatment of the Aging Hand with Juvéderm Ultra® 3 and Juvéderm® Hydrate

Dallara, Jean-Marie

doi:10.1007/s00266-012-9890-5

Cited by 17 publications

(7 citation statements)

References 6 publications

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“…As more patients undergo facial rejuvenation treatments, discrepancies in the appearance of a youthful face and aged hands may become bothersome and reveal a patient's true age. 2 , 6 Accordingly, greater numbers of aesthetically aware patients are seeking hand rejuvenation treatments.…”

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confidence: 99%

“…Several treatments are used to restore lost volume and minimize the appearance of veins and tendons in the hand, including injectable hyaluronic acid, 6 poly- l -lactic acid, 7 and calcium hydroxylapatite 8 ; autologous fat transfer 2 ; vein treatment (sclerotherapy) 2 ; chemical peels 2 ; and laser and light therapies. 2 One photonumeric scale has been validated for photographic 9 and live-subject 10 assessments of the severity of hand aging.…”

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confidence: 99%

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Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Hand

Jones

Donofrio

Hardas

et al. 2016

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BACKGROUNDA validated scale is needed for objective and reproducible comparisons of hand appearance before and after treatment in practice and clinical studies.OBJECTIVETo describe the development and validation of the 5-point photonumeric Allergan Hand Volume Deficit Scale.METHODSThe scale was developed to include an assessment guide, verbal descriptors, morphed images, and real-subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 296) completed during 2 sessions occurring 3 weeks apart.RESULTSA score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 1.12 [0.99–1.26] for clinically different image pairs and 0.45 [0.33–0.57] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was almost perfect (mean weighted kappa = 0.83). Interrater agreement was almost perfect during the second session (0.82, primary end point).CONCLUSIONThe Allergan Hand Volume Deficit Scale is a validated and reliable scale for physician rating of hand volume deficit.

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confidence: 99%

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Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Hand

Jones

Donofrio

Hardas

et al. 2016

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“…It has also been commonly used as a debriding topical agent for wound care [14]. FDA approved hyaluronic acid based dermal fillers have also been safely employed for reconstructive reasons [15-17]. However, of all the procedures mentioned, autologous fat grafting has the longest track record of use well prior to the advent of modern medicine [18].…”

Section: Discussionmentioning

confidence: 99%

Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy

Wu¹,

Morrow²

2013

J Transl Med

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BackgroundIn an attempt to engineer a regulatory compliant form of cell assisted lipotransfer in the U.S., the authors developed Autologous Fat Transfer with In-situ Mediation (AIM) for reconstruction of a refractory surgical scar.MethodsThis method incorporates use of accepted standard procedures like autologous fat grafting and intradermal injection of NB6 collagenase to release adipose stem cells from a naturally occurring high concentration stromal vascular fraction (SVF) fat graft. To prevent off-target effects of collagenase, a hyaluronic acid and serum deactivation barrier is placed circumferentially around the operative site.FindingsThis novel protocol was well tolerated by the patient and improved scar appearance, mobility and texture. Deepest scar contour defect correction was 80% and 77% at 4 and 12 weeks respectively.ConclusionAIM appears to be a practical and viable option for scar reconstruction requiring small to moderate volume correction.

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“…Both the investigators and the patients reported a significant aesthetic improvement. 36 However, these agents are not currently available in the United States. Another study looked at long-term effectiveness of small gel particle (SGP)-HA for the hands in 16 patients.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Hand Rejuvenation Using a Combination Approach

Butterwick

Sadick

2016

Dermatologic Surgery

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A Prospective, Noninterventional Study of the Treatment of the Aging Hand with Juvéderm Ultra® 3 and Juvéderm® Hydrate

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors at www.springer.com/00266.

Cited by 17 publications

References 6 publications

Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Hand

Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Hand

Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy

Hand Rejuvenation Using a Combination Approach

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