A prospective, open label, clinical study for evaluation of management of chronic non-healing, non-diabetic leg ulcers in a tertiary care hospital

Mukherjee, Sujoy; Raza, Mohd. Arshad; Mukherjee, Shobha; Bansal, Piyush; Joshi, Gaurav

doi:10.18203/2349-2902.isj20151080

Cited by 1 publication

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“…Compared to diabetic foot ulcers which cause considerable morbidity and mortality along with increased cost of management, non-diabetic chronic lower extremity ulcers cause lesser morbidity and negligible mortality. 10 Therefore, a proper wound care, modification in lifestyle and hygiene, health education and treatment or removal of precipitating cause of chronic leg ulcer promotes healing. The regenerative medicine is utilizing therapeutic potential of the stem cells to promote skin regeneration following injuries or post debridement.…”

Section: Discussionmentioning

confidence: 99%

Non diabetic chronic leg ulcers: etiology and management

et al. 2019

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An accurate diagnosis is essential to avoid inappropriate treatment that may cause deterioration of the wound, delay in wound healing or harm to the patient. Hence, knowing the etiology of the chronic leg ulcers becomes an important pivot for research in managing the wound and also increases the quality of life along with reduction of the financial burden. Since there is paucity of research ABSTRACT Background: Chronic leg ulceration has varied etiologies and a systemic approach towards its pathogenesis, definitive diagnosis and optimal treatment is the need of the hour. Paucity of research data on non-diabetic chronic leg ulcer becomes the rational of present study. Methods: Total number of 60 patients with non-healing ulcer below knee and above ankle for more than 6 weeks duration were included in this observational study. A detailed clinical presentation, relevant biochemical, microbiological and imaging investigations were recorded. The management of these ulcers was based on its etiology with an approach to conservative management (antibiotics, daily dressings, improvement in nutritional status) to surgical debridement, wide local excision followed by split thickness/full thickness skin grafting. Outcome of present study was in terms complete or partial healing of ulcer, persistence or recurrence of ulcer. Results: Majority of patients (28.33%) with chronic leg ulcer presented during sixth decade with a male to female ratio of 5:1. The mean duration of chronicity of ulcer was 17.75 months with standard deviation of 7.83 months. Trauma was the commonest etiological factor (45%) followed by venous insufficiency (31.66%). About 31.66% of ulcers were managed conservatively and 68.32% by surgical procedure. Complete healing rate was found in 66.67% patients, persistence of ulcer in 18.32%, partial healing in 11.67% patients and 1.67% patient showed recurrence. Conclusions: Trauma and venous etiology were commonest cause of chronic leg ulcer. A comprehensive etiological assessment and judicious use of conservative or surgical therapy are pivotal in management of these ulcers.

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Section: Discussionmentioning

confidence: 99%