A Prospective Open Study of the Efficacy of High‐Dose Recombinant Hepatitis B Rechallenge Vaccination in HIV‐Infected Patients

Abstract

Double-dose hepatitis B virus revaccination of human immunodeficiency virus (HIV)-infected patients proved to be effective in 50.7% of 144 patients who had previously failed to respond to standard doses. In the multivariate analysis, female patients were found to have a significantly better response (P= .03). The effect of age on the response depended on the viral load at the time of revaccination. For patients with a detectable HIV RNA load, the effect of age was stronger (odds ratio [OR], 0.34 per 10 years older [95% confidence interval {CI}, 0.16-0.72]; P= .005) than for patients with an undetectable HIV RNA load (OR, 0.74 per 10 years older [95% CI, 0.50-1.09]; P= .12).

Seroprevalence of HBV and HIV Co-infection in Children in Nnewi, South-East, Nigeria

“…While the prevalence rate of HBV obtained among HIV negative (0.8%) in this study is comparable to findings of an Ibadan [29] study (0.5%) that used similar method of assay it is however, lower than the reports from other studies [30,31]. This may be related to differences in population characteristics such as exposure to risk factors, socioeconomic status, HBV immunization rates and methods of assay.…”

Safety and Immunogenicity of 4 Intramuscular Double Doses and 4 Intradermal Low Doses vs Standard Hepatitis B Vaccine Regimen in Adults With HIV-1

“…16 .36 Fever 7 (5) 18 (13) 11 (8) .03 .47 Myalgia 10 (7) 20 (14) 7 (5 (2) 10 (7) 28 (20) .09 Ͻ.001 Nodule 8 (6) 10 (7) 21 (15) .81 .02 Induration 5 (4) 9 (6) 19 (14) .41 .005 Edema 1 (1) 9 (6) 15 (11) .02 Ͻ.001 c Only events that occurred in at least 8% of patients in either vaccination group are shown to be able to present the data concisely (for complete data on adverse events, see eTable 2; available at http://www.jama.com). d Hypertransaminemia was defined as alanine aminotransferase or aspartate aminotransferase or both at levels more than 1.25 times the upper limit of normal.…”

Vaccination in HIV-Infected Adults

“…Responses rates to the second vaccine series vary, but have been reported as 51-77%. 57,58 Since vaccine response rates are correlated with the immunocompetence of the host, some experts suggest delaying the second vaccine series among initial nonresponders until receipt of CART and a higher CD4 count. Response rates to vaccination have been estimated as 30-50% and 60-70% among not receiving and receiving CART, respectively.…”