A prospective, randomized comparison of Oxyglobin (HB‐200) and packed red blood cell transfusion for canine babesiosis

Abstract

Objective -To establish the efficacy of Oxyglobin in canine babesiosis and compare it to standard therapy, packed red blood cell transfusion (pRBCT) with respect to improvements in specific parameters of blood gas, acid-base, blood pressure, and subjective evaluations. Design -Prospective, randomized, clinical trial. Setting -Onderstepoort Veterinary Academic Hospital. Animals -Twelve dogs (8-25 kg) naturally infected with Babesia rossi and a hematocrit of 0Interventions -Treatment groups were randomized to receive either 20 mL/kg of Oxyglobin or pRBCT over 4 hours via a central venous catheter. Transfusions were followed by lactated Ringer's solution infusion. Rectal temperature, femoral arterial and mixed venous blood sampling, oscillometric blood pressure, and subjective assessment of patient status (habitus), and appetite were performed at time points 0, 1, 4, 8, 24, 48, and 72 hours. Main Results -Dogs presented with a hypoalbuminemic alkalosis; hyperchloremic, dilutional acidosis; normotensive tachycardia; pyrexia; depression; and anorexia. Both treatments produced similar results, with the exception of significant differences in pH (4 h); PCO 2 (4 h); hemoglobin (8 h, 24 h); mean arterial pressure (48 h); albumin (4 h, 8 h); habitus (8 h, 48 h); and appetite (24 h). Arterial O 2 content was higher for pRBCT than Oxyglobin at 72 hours, but central venous PO 2 did not differ between groups or over time and was consistently subnormal. Conclusions -Oxyglobin provides similar overall improvements to pRBCT in dogs with anemia from babesiosis, with respect to blood gas, acid-base and blood pressure, although patients receiving packed cells tended to have more rapid normalization of habitus and appetite.

ACVIM consensus statement on the treatment of immune‐mediated hemolytic anemia in dogs

“…Only a single direct comparison of BHS and pRBC has been undertaken in dogs during an RCT comparing administration of the 2 products for stabilization of dogs with babesiosis. No difference in recovery of acid/base and perfusion variables was found, but those dogs receiving pRBC had a faster clinical recovery …”

“…No difference in recovery of acid/base and perfusion variables was found, but those dogs receiving pRBC had a faster clinical recovery. 39 In conclusion, BHS could be administered if pRBC or whole blood are not available. However, BHS currently is unavailable in many countries, including the United States.…”

Comparison ofHb‐200 and 6% hetastarch 450/0.7 during initial fluid resuscitation of 20 dogs with gastric dilatation‐volvulus

“…Clinical reports describe the use of Hb‐200 in treating anemia and hypotension in dogs and cats. Zambelli and Leisewitz administered 20 mL/kg of Hb‐200 over 4 hours to anemic dogs diagnosed with clinical babesiosis. All dogs treated with Hb‐200 had an SBP that remained <160 mm Hg.…”

Blood Transfusion and Blood Substitutes

“…95,133 One was a multicenter clinical trial for dogs with moderate to severe anemia (PCV, 6% to 23%). 95,133 One was a multicenter clinical trial for dogs with moderate to severe anemia (PCV, 6% to 23%).…”

“…95,133 One was a multicenter clinical trial for dogs with moderate to severe anemia (PCV, 6% to 23%). 133 Blood gas, acid-base, and blood pressure were objective measures of response to treatment. Dogs in both groups were monitored for a decrease in hemoglobin concentration or deterioration in physical condition at which time they received additional oxygen-carrying support.…”