A prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate in ERCP: effects on technical success and post-ERCP pancreatitis

Kaffes, Arthur J.; Bourke, Michael J.; Ding, Stephen; Alrubaie, Ahmad; Kwan, Vu

doi:10.1016/j.gie.2005.11.060

Cited by 59 publications

(69 citation statements)

References 17 publications

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“…In the similar study of Kaffes et al, GTS was found to have no influence over prevention of post-ERCP pancreatitis (7.7%, 7.4%) (23). Botulinum toxin is another agent used for this purpose.…”

Section: Discussionmentioning

confidence: 93%

The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

Bozkurt

Güner²,

Kadıoğlu³

et al. 2013

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 93%

The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

Bozkurt

Güner²,

Kadıoğlu³

et al. 2013

Turk J Gastroenterol

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“…Our study revealed that sublingual glyceryl trinitrate (5 mg) before ERCP could reduce pancreatitis and hyperamylasemia. Kaffes et al [11] showed that ransdermal GTN could not improve the success rate of ERCP cannulation or prevent post-ERCP pancreatitis in either average or high-risk patient groups.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: A randomized placebo-controlled trial

Hao¹,

Wu²,

Wang³

et al. 2009

WJG

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A I M :To e x a m i n e t h e p r o p h y l a c t i c e f f e c t o f glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia. METHODS:Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers. RESULTS:A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037). CONCLUSION:Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.

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“…Problems with both of these studies include background rates of pancreatitis in the control groups that seemed unusually high for low-to average-risk patient groups and limited assessment of efficacy in high-risk patients. A recent prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate involving 318 patients did not show any improvement in the rate of success in ERCP cannulation or prevention of PEP in either average or high-risk patient groups [127] . Reducing the risk of post-procedure infection.…”

Section: Category 3: Markers Of Systemic Inflammationmentioning

confidence: 90%

Pancreatits after endoscopic retrograde cholangio-pancreatography

Aziz

Lehman

2007

WJG

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Pancreatitis is the most common complication after endoscopic retrograde cholangio-pancreatography (ERCP); the reported incidence of this complication varies from less than 1% to 40%, but a rate of 4%-8% is reported in most prospective studies involving nonselected patients. Differences in criteria for defining pancreatitis, methods of data collection, and patient populations (i.e. number of high-risk patients included in the published series) are factors that are likely to affect the varying rates of post-ERCP pancreatitis. The severity of post-ERCP pancreatitis (PEP) can range from a minor inconvenience with one or two days of added hospitalization with full recovery to a devastating illness with pancreatic necrosis, multiorgan failure, permanent disability, and even death. Although, most episodes of PEP are mild (about 90%), a small percentage of patients (about 10%) develop moderate or severe pancreatitis. In the past, PEP was often viewed as an unpredictable and unavoidable complication, with no realistic strategy for its avoidance. New data have aided in stratification of patients into PEP risk categories and new measures have been introduced to decrease the risk of PEP. As most ERCPs are performed on an outpatient basis, the majority of patients will not develop PEP and can be discharged. Alternatively, early detection of those patients who will go on to develop PEP can guide decisions regarding hospital admission and aggressive management. In the last decade, great efforts have been addressed toward prevention of this complication. Points of emphasis have included technical measures, pharmacological prophylaxis, and patient selection. This review provides a comprehensive, evidence-based assessment of published data on PEP and current suggestions for its avoidance.© 2007 The WJG Press. All rights reserved.Key words: Endoscopic retrograde cholangiopancreatography; Post-ERCP pancreatitis Abdel Aziz AM, Lehman GA. Pacreatitis after endoscopic r e t r o g r a d e c h o l a n g i o -p a n c r e a t o g r a p h y . W o r l d J

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A prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate in ERCP: effects on technical success and post-ERCP pancreatitis

Cited by 59 publications

References 17 publications

The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: A randomized placebo-controlled trial

Pancreatits after endoscopic retrograde cholangio-pancreatography

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