A prospective study of asthma incidence and its predictors: the RHINE study

Torén, K.; Gislason, T.; Omenaas, E.; Jögi, R.; Forsberg, B.; Nyström, L.; Olin, A-C.; Svanes, C.; Janson, C.

doi:10.1183/09031936.04.00044804

Cited by 84 publications

(103 citation statements)

References 25 publications

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“…The first part of the questionnaire contained questions identical to the original version, i.e. items about asthma symptoms [12]. A second part included items about self-reported asthma.…”

Section: Methodsmentioning

confidence: 99%

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Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Holm

Omenaas²,

Gíslason³

et al. 2007

Eur Respir J

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The aim of the present study was to investigate the remission rate of adult asthma in a general population sample in relation to age, sex, asthma symptoms, allergic rhinitis and smoking.A follow-up of the random population samples from the European Community Respiratory Health Survey in Northern Europe was conducted from 1999-2001 on 1,153 individuals (aged 26-53 yrs) with reported asthma. Remission was defined as no asthmatic symptoms in two consecutive years and no current use of asthma medication. Remission rates per 1,000 personyrs were calculated and Cox regression models, adjusting for confounders, were used to estimate hazard ratios (HR) with 95% confidence intervals (CI).An average remission rate of 20.2 per 1,000 person-yrs was found. There was no significant difference according to sex; the remission rates were 21.7 and 17.8 per 1,000 person-yrs in females and males, respectively. An increased remission rate was observed among subjects who quit smoking during the observation period. Subjects not reporting any asthma symptom at baseline had an increased remission rate. In the Cox regression model, ex-smoking (HR 1.65, 95% CI 1.01-2.71) was associated with increased remission rate, and reporting any asthma symptom at baseline was associated with decreased remission rate (HR 0.7, 95% CI 0.40-0.90).In conclusion, the present prospective longitudinal study showed that quitting smoking and the presence of mild disease appeared to favour remission.

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“…The first part of the questionnaire contained questions identical to the original version, i.e. items about asthma symptoms [12]. A second part included items about self-reported asthma.…”

Section: Methodsmentioning

confidence: 99%

“…At follow-up all subjects were mailed a questionnaire [12]. The centres mailed the follow-up questionnaires in different years, but all centres performed the follow-up at any year during the period 1999-2001.…”

Section: Methodsmentioning

confidence: 99%

Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Holm

Omenaas²,

Gíslason³

et al. 2007

Eur Respir J

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“…Since there exists no gold standard for asthma, any definition has limitations. We used doctor-diagnosed asthma, which has been found to have high specificity and low sensitivity [40]. Therefore, we would expect, if anything, an underreporting.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study

et al. 2015

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A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland and its relation to sex, taking into account age and allergic sensitisation.We assessed incidence of self-report of doctor-diagnosed asthma between 1991/1992 and 2010/2011 in 5128 subjects without asthma, aged 18-60 years at baseline. The age-related probability of asthma onset was analysed by logistic regression adjusting for potential confounders and stratified by sex and allergic sensitisation at baseline.Over 20 years, 128 (5.1%) men and 198 (7.5%) women newly reported doctor-diagnosed asthma. The adjusted odds ratio for female sex was 1.99 (95% CI 1.54-2.57) overall, 3.21 (95% CI 2.12-4.85) among nonsensitised subjects, and 1.43 (95% CI 1.02-2.02) in sensitised subjects. The probability of asthma onset decreased with increasing baseline age in women but not in men. The higher probability of new asthma in sensitised compared with nonsensitised men was unrelated to age, whereas in women it decreased with age.Asthma incidence was higher in women than in men but decreased with increasing age. The female predominance was considerably stronger in nonsensitised adults compared with those with allergic sensitisation. @ERSpublications Female predominance in new-onset adult asthma decreased with age and was more pronounced in nonsensitised subjects

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“…A few studies have prospectively assessed the incidence of asthma and/or nasal allergy in adulthood using a 10-year follow-up [3][4][5][6]. Most of these papers have utilised data from the European Community Respiratory Health Survey (ECRHS).…”

Section: Introductionmentioning

confidence: 99%

Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

et al. 2013

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Limited information exists regarding the incidence and predictors of asthma and nasal allergy in adulthood. We determined the incidence rate of asthma and nasal allergy in adults and assessed the predictive value of skin prick tests (SPTs) and radioallergosorbent tests (RASTs) for these two outcomes.Two German centres involved in the European Community Respiratory Health Survey conducted a follow-up assessment in 2012 of the baseline participants (1185 adults aged 21-47 years assessed in 1990). The predictive value of SPTs and RASTs on new-onset asthma and nasal allergy was assessed by Cox regression and by calculating the positive or negative predictive value.During the 20 years between baseline and follow-up, 3.1 and 4.4 per 1000 person-years of new-onset asthma and nasal allergy cases were recorded, respectively. The hazard ratios for SPTs of any specific and of all aeroallergens combined were slightly higher than those of RASTs for asthma and nasal allergy. The negative predictive values of both the SPT and RAST were very high and similar (0.94-0.96), whereas the postive predictive values were low (0.09-0.20).Positive SPT results showed a better association with new onset asthma and nasal allergy than positive RAST either to any specific aeroallergens or to all combined. @ERSpublications Positive SPT shows better association with new-onset asthma and nasal allergy than positive radioallergosorbent tests

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A prospective study of asthma incidence and its predictors: the RHINE study

Cited by 84 publications

References 25 publications

Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study

Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

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