A Prospective Study of Serum Carcinoembryonic Antigen in Patients with Newly Diagnosed Colorectal Cancer and Healthy Individuals

Younesi, Mohammad Reza

doi:10.21767/2386-5180.100098

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…There are several studies on the interaction of the CEA tumor marker with colorectal cancer. CEA is a tumor marker that is overexpressed, especially in colorectal cancer, and there are many conflicting findings about the sensitivity and usefulness of this tumor marker (19,20). The percentages of the individuals included in the reference range of 7 different gene and biomarkers were compared (see Figure II).…”

Section: Discussionmentioning

confidence: 99%

Kolorektal Kanseri Teşhi̇s İçi̇n Yedi̇ Kan Bi̇yobeli̇rteçleri̇ Üzeri̇nde Karşilaştirmali Anali̇z

Bursalıoğlu¹

2020

Sağlık Bilimleri Dergisi

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Cancer has become one of the most important causes of mortality that human beings have faced in this century. Because the digestive system is a region where nutrients are involved and processed in the human body, colorectal cancer (CRC) has been increasing in recent years due to irregular and bad nutrition, stress, immobility and increased environmental pollution. Early detection has become one of the most important ways to stay alive in cancer. In recent years, artificial intelligence studies have begun to be used in the diagnosis and treatment of cancer. In this study, there is a search for early and practical diagnosis by analyzing some blood data acquisition related to colon cancer from different literatures together. Seven different biomarkers and blood-related gene data acquisition were used in the literature and WBC, CRP and CEA type may be used as biomarkers to diagnosis and follow-up for colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Kolorektal Kanseri Teşhi̇s İçi̇n Yedi̇ Kan Bi̇yobeli̇rteçleri̇ Üzeri̇nde Karşilaştirmali Anali̇z

Bursalıoğlu¹

2020

Sağlık Bilimleri Dergisi

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Multivariate Investigation of Toxic and Essential Metals in the Serum from Various Types and Stages of Colorectal Cancer Patients

Mahmood

Qayyum

Yaseen

et al. 2021

Biol Trace Elem Res

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Biocompatible graphene-zirconia nanocomposite as a cyto-safe immunosensor for the rapid detection of carcinoembryonic antigen

Lin

Tham

Loh

et al. 2021

Sci Rep

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Graphene-based materials have gained remarkable attention in numerous disciplines owing to their unique electrochemical properties. Out of various hybridized nanocomposites, graphene-zirconia nanocomposite (GZ) was distinctive due to its biocompatibility. Zirconia nanoparticles serve as spacers that reduce the stacking of graphene and improve the electrochemical performance of the material. Considering that lungs and skin suffer the greatest exposure to nanoparticles, this study aimed to evaluate the cytotoxicity of the as-synthesized GZ nanocomposites on MRC5 (lung cells) and HaCaT (skin cells) via morphological observation and cell viability assay using 3-(4,5 dimethylthiazol-2-yl)-(2,5-diphenyltetrazolium bromide) tetrazolium (MTT). GZ-treated cells showed a comparable proliferation rate and morphology with untreated cells under microscopic evaluation. Based on MTT results, the IC50 values of GZ were > 500 µg/ml for MRC5 and HaCaT cells. The excellent biocompatibility was the supremacy of GZ over other nanocomposites applied as electrode materials in biosensors. GZ was functionalized with biolinker for the detection of carcinoembryonic antigen (CEA). The proposed immunosensor exhibited good responses towards CEA detection, with a 4.25 pg/ml LOD and correlation coefficient of R2 = 0.99 within a linear working range from 0.01 to 10 ng/ml. The performance of the immunosensor to detect CEA present in human serum was also evaluated. Good recovery of CEA was found, suggesting that the proposed immunosensor possess a high affinity to CEA even in a complex biological matrix, rendering it a promising sensing platform for real sample analysis and open a new way for the detection of cancer-associated proteins.

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A Prospective Study of Serum Carcinoembryonic Antigen in Patients with Newly Diagnosed Colorectal Cancer and Healthy Individuals

Cited by 3 publications

References 13 publications

Kolorektal Kanseri Teşhi̇s İçi̇n Yedi̇ Kan Bi̇yobeli̇rteçleri̇ Üzeri̇nde Karşilaştirmali Anali̇z

Kolorektal Kanseri Teşhi̇s İçi̇n Yedi̇ Kan Bi̇yobeli̇rteçleri̇ Üzeri̇nde Karşilaştirmali Anali̇z

Multivariate Investigation of Toxic and Essential Metals in the Serum from Various Types and Stages of Colorectal Cancer Patients

Biocompatible graphene-zirconia nanocomposite as a cyto-safe immunosensor for the rapid detection of carcinoembryonic antigen

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