A Prospective Study on Intrapartum Risk Factors for Birth Asphyxia

Krishnan, Murali; Padarthi, SreeChandu

doi:10.9790/0853-1509120407

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…This figure is very high when compared with prevalence of 0.24% in Canada, 0.85% in the Netherlands, 2.5% observed in Dire Dawa, Ethiopia, and 2.69 in Nepal but lower than the study in Nigeria which was 29.4% [10, 13–16]. In addition, male to female ratio was found to be 1.07:1 which is similar to study in India [17]. This difference could be due to the level of quality care provided during antenatal, natal, or postnatal period among nations.…”

Section: Discussionsupporting

confidence: 65%

“…In contrary, a large size of a baby at birth (a proxy for birth weight) had been found an associated factor for birth asphyxia-related neonatal mortality [20]. Meconium-stained amniotic fluid also found significantly associated with the incidence of perinatal asphyxia like other studies indicated it before [9, 11, 17, 25]. Presence of meconium in the amniotic fluid may lead to aspiration of it into the lung that could eventually result in perinatal asphyxia.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018

Gebreheat

Gebru

Kiros

et al. 2018

BioMed Research International

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Perinatal asphyxia is one of the most important causes of morbidity and mortality in neonates. Perinatal asphyxia occurs in association with maternal, fetal, and maternofetal factors. However, the magnitude and associated factors of perinatal asphyxia are not well studied in Tigray, Ethiopia. Therefore, our study is conducted to determine the prevalence and factors associated with perinatal asphyxia among neonates in general hospitals of Tigray. An observational hospital-based cross-sectional study was conducted in randomly selected general hospitals. A semistructured questionnaire was used to collect data from 421 randomly selected neonates with their mothers and medical records. The data was entered into epidata version 3.5 and exported to Statistical Package for Social Sciences (SPSS) version 20 for analysis. Finally, the presence of an association between a dependent variable and an independent variables has been declared at P-value ≤0.05, or adjusted odds ratio (AOR), 95% confidence interval (CI). Accordingly, the result of this study showed that the prevalence of perinatal asphyxia among the selected general hospitals was 22.1%. Neonates born with cesarean section are seven times more likely to have perinatal asphyxia than those who are born spontaneously through the vagina (AOR, 6.97; CI (2.87-16.93)). In addition, neonates who are born meconium stained are 8.55 times more likely to have perinatal asphyxia than those who had not stained with meconium (AOR, 8.55; CI (4.20-17.39)). Neonates who are weighed less than 2.5 kg are 12.75 times more likely to have perinatal asphyxia than those who are weighed 2.5-4 kg (AOR, 12.75; CI (4.05-40.08)). Prolonged duration of labour was also associated statistically with perinatal asphyxia (AOR, 3.33, CI (1.32-8.38)). In conclusion, the magnitude of perinatal asphyxia in general hospitals of Tigray remains high. Low birth weight, meconium-stained amniotic fluid, cesarean section, and prolonged maternal labour have been associated with perinatal asphyxia.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018

Gebreheat

Gebru

Kiros

et al. 2018

BioMed Research International

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“…The current study revealed that the odds of developing perinatal asphyxia was 4 times higher in neonates of mothers who had meconium-stained amniotic fluid than those without meconium-stained amniotic fluid. Such was demonstrated in the general hospitals of Tigray [17] and also [20,28,29]. MASF is often associated with fetal hypoxia which promotes meconium discharge in amniotic fluid, gasping and aspiration of MSAF, and also changes in the vascular muscular of pulmonary blood vessels of the fetus [30].…”

Section: Discussionmentioning

confidence: 90%

Prevalence and Associated Factors of Perinatal Asphyxia in Neonates Admitted to Ayder Comprehensive Specialized Hospital, Northern Ethiopia: A Cross-Sectional Study

Gebregziabher

Hadgu

Abebe

2020

International Journal of Pediatrics

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Background. Perinatal asphyxia is defined as the inability of the newborn to initiate and sustain enough respiration after delivery and is characterized by a marked impairment of gas exchange. It is one of the most common causes of neonatal mortality and morbidity. There are very few studies on perinatal asphyxia in Tigray, and so this study is aimed at assessing the prevalence and associated factors of perinatal asphyxia in Ayder Comprehensive Specialized Hospital NICU, Tigray, Ethiopia. Methods. An institution-based cross-sectional study design was conducted among neonates admitted to Ayder Comprehensive Specialized Hospital from January 1, 2016, to December 30, 2017. Medical records of 267 neonates admitted to the neonatal intensive care unit were selected by a systematic sampling method, and relevant information was collected using a checklist. The data was analyzed using SPSS version 20. Descriptive statistics were computed to determine the prevalence of birth asphyxia and sociodemographic and obstetrics data. Binary logistic regression was used to test associations between the associated factors and perinatal asphyxia. First bivariate analysis was performed to assess the association without controlling the effect of other independent variables. Variables with P value < 0.25 were fitted to the multivariable binary logistic regression model. Finally, variables with P value < 0.05 were expressed as associated factors of perinatal asphyxia. Results. Of the 267 neonates, 48 neonates had perinatal asphyxia, giving a prevalence of 18%. Prolonged labor (AOR=5.19, 95% CI: 1.73-15.63, P=0.003), presence of meconium (AOR=4.17, 95% CI: 1.34-12.98, P=0.014), and preeclampsia (AOR=7.94, 95% CI: 2.22-28.37, P=0.001) were important determinant factors for birth asphyxia. The case fatality rate of perinatal asphyxia was 37.5%. Conclusion and Recommendations. Prevalence and mortality of asphyxia were high. Prolonged labor, presence of meconium, and preeclampsia were determinant factors for birth asphyxia. Early detection and intervention of high-risk mothers should be carried out by health care providers, and mothers should be monitored with partograph during labor.

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“…The structure geometries of these complexes have been investigated by elemental analysis, conductivity measurements, FT-IR and UV-visible spectra. acids (aaH) such as alanine (alaH), phenyl alanine (phealaH), tyrosine (tyrH), methionine (metH) and glycine (glyH) were reported [25]. These complexes have been characterized by spectroscopic, magnetic susceptibility studies, elemental and thermal analysis.…”

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confidence: 99%

“…The antioxidant properties of complexes show the gradation due to the presence of different amino acids and hence it could be proved that the presence of a second ligand affects the properties of complex. The selectivity index as high as 32 and 64, which indicates the fact that these compounds could be used as good anticancer agents [25]. Ekennia et al [26] prepared a novel N-methyl-N-phenyl dithiocarbamate and its Ni(II), Co(II), Cu(II) and Mn(II) complexes (Schemes IV and V).…”

mentioning

confidence: 99%

Metal Complexes of Dithiocarbamate Derivatives and its Biological Activity

Ahmed¹

2018

Asian J. Chem.

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In chelate complexes the metal ion performs a coordination with two or more donor atoms of the same ligand. The chelate impact means preferring metal ions in order to create complexes with chelating ligand instead of non-chelating ones in which the two types of ligands are capable of forming bonds of similar strength. The impact of the chelate is influenced by the effects of enthalpy and entropy [1]. Metal complexes of oxygen, sulfur and nitrogen-chelating ligands gained consideration owing to their curiously explanatory [2], biological [3] and physico-chemical [4], properties, articulated biological activities and for their utility as models of metalloenzyme dynamic sites [5]. In coordination of metals, sulfur and nitrogen atoms play a key part at the dynamic destinations of various metallobimolecules [6]. The intrigued in sulfur given chelating operators have developed exceptionally rapidly [7]. Coordination chemistry is centered on potential applications of macrocylic thio Schiff bases and their metal complexes [8]. Dithiocarbamates are very common compounds binding strongly and selectively to a wide range of metal ions, therefore, in the past decade self-assembly which is controlled by the MINI REVIEW Metal Complexes of Dithiocarbamate Derivatives and its Biological Activity

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A Prospective Study on Intrapartum Risk Factors for Birth Asphyxia

Cited by 4 publications

References 10 publications

Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018

Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018

Prevalence and Associated Factors of Perinatal Asphyxia in Neonates Admitted to Ayder Comprehensive Specialized Hospital, Northern Ethiopia: A Cross-Sectional Study

Metal Complexes of Dithiocarbamate Derivatives and its Biological Activity

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