A Prospective Study on Prevalence and Antibiotic Susceptibility Pattern of <i>Acinetobacter baumannii</i> in Clinical Samples obtained from Patients admitted in Various Wards and Intensive Care Units

Sharma, Rajesh; Mamoria, Ved Prakash

doi:10.5005/jp-journals-10057-0050

Cited by 3 publications

(5 citation statements)

References 25 publications

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“…However, the subsequent data from 12 European countries18 revealed a significant increase in the resistance rates against imipenem (42.5%) and meropenem (43.4%) [25].Data of the antibiotic susceptibilities from different geographical regions revealed that the resistance of Acinetobacter spp. to imipenem was in the range of, no resistance to 40% (2000-2004) [26].Other studies have also reported increasing resistance to carbapenems [9,23],which is reflected in our study as well.…”

Section: Resultssupporting

confidence: 86%

“…Gender ratio was 1.9:1, which shows a female preponderance in our study. This was not the case with most studies that reported a slight male preponderance [7][8][9]. Saha et al and Sivaranjaniet al [11,12] have reported slight predominance of female patients over male.…”

Section: Resultsmentioning

confidence: 84%

“…While,Shanthiet al [16]reporteda maximum number of isolates from endotracheal (ET) secretion (41.8%), followed by urinary tract (25.5%), wound (20%) and blood (12.7%). Sharma et al [9] and Jaggiet al [14]also reported maximum isolates from respiratory secretions.…”

Section: Resultsmentioning

confidence: 97%

“…None of the isolates were resistant to colistin. Most of the Acinetobacterspp sensitivity study in India and US [9,11,12,14,28,29]have reported mostly zero or around 1% resistance to colistin.Studies in other countries have however shown increase in colistin resistance. Study in Western Pacific [30] region showed 3.3% resistance to colistin.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence and Antibiotic Susceptibility of Acinetobacterin a Tertiary Care Hospital in Chennai, India

Anjali

Abiramasundari

2021

Int J Curr Pharm Sci

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Objective: The present study is to determine the prevalence and antibiotic susceptibility of Acinetobacter species in samples collected from patients in tertiary care hospital in Chennai. Methods: A total of17,827patient’s clinical samples were collected from various wards and ICUs of Saveetha Medical College and Hospital, Chennai, Tamilnadu over a period of 7 mo [between January 2020 and July 2020]. All samples were tested in the microbiology lab of Saveetha Medical College and Hospital using standard operating procedures. Results: Out of 17,827 samples, 2,816 were culture positive. 122 of the isolates tested positive for Acinetobacter spp.and 81.1% of the isolates belonged to Acinetobacterbaumannii. Most of the infection occurred in the age group of 21-40 y and predominantly in female patients (female, male ratio 1.9:1).General wards contributed to 54.9% of the Acinetobacter infection, followed by ICU(27%) and OPD(18%). Maximum isolates were recovered from urine(34.4%) and endotracheal secretions(29.5%).60.7% of the Acinetobacterspp were multidrug-resistant(MDR)i.e. resistant to more than 3 antibiotic group.In our study, most Acinetobactersppwere resistant to penicillin(46-100%), third and fourth generation cephalosporin (36-61.5%), carbapenems (34.4-82.8%)and quinolones(39.3-46.7%). None of the isolates were resistant to colistin. 93.4% ofisolates were sensitive to tigecycline and 87.7% sensitive to amikacin. Conclusion: Our study observed a high incidence of MDR inAcinetobacterspp, which is in line with most of the research findings in recent times. Most of Acinetobacterspp were resistant to penicillin, third and fourth generation cephalosporins, quinolones, carbapenems,which is alarming as it leaves fewer options for the line of treatment. Some strains were sensitive to cefepime, ceftazidime, piperacillin-tazobactam, levofloxacin, imipenem and meropenem. Considering the increasing MDR nature of Acinetobacterspp a combination of the former along with colistin, tigecycline, amikacin(which have shown more than 85% sensitivity) would need to be studied.Also, strict measures to control the spread of Acinetobacter infection, better management of antibiotics usage and newer therapeutic option for treatment need to be looked at.

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and Antibiotic Susceptibility of Acinetobacterin a Tertiary Care Hospital in Chennai, India

Anjali

Abiramasundari

2021

Int J Curr Pharm Sci

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“…There was no gender-based difference in the frequency of isolation of A. baumannii in the current study, which is in contrast with the findings of previous studies showing a higher frequency of isolation among males. [ 14 15 ] Medical and surgical interventions such as urinary and central venous catheterization, mechanical ventilation, prior surgery, etc., are potential risk factors associated with A. baumannii infection. [ 16 17 ] In the current study, the majority of the patients had been exposed to one or more of these interventions either in the wards or ICUs.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Pattern of Acinetobacter baumannii Strains

Sannathimmappa

Nambiar

Aravindakshan

2021

Saudi Journal of Medicine &Amp; Medical Sciences

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Background: Multidrug-resistant (MDR) Acinetobacter baumannii is of serious health concern and associated with high mortality. Data regarding the antibiotic resistance pattern of A. baumannii strains in Oman is limited. Objectives: To determine the antibiotic resistance pattern of A. baumannii from various clinical samples in a tertiary care hospital in the North-Batinah region of Oman. Methods: A. baumannii isolates recovered from various clinical samples in the Microbiology laboratory of Sohar Hospital, Oman, during 2015–2019 were retrospectively analyzed. Organism identification and their antibiotic resistance patterns were performed as recommended by the Clinical and Laboratory Standards Institute. Results: A total of 1890 A. baumannii nonduplicate isolates were found from clinical samples of 1326 patients. The isolates were more frequently isolated from elderly patients (40%) and in-patient department patients (67%). Infection/colonization was more common among patients treated in the medicine, intensive-care unit, and surgery departments. A. baumannii strains were highly resistant (50-83%) to most of the tested antibiotics, with the highest against ceftriaxone (83%) and ceftazidime (75%), and lowest against colistin (1%) and tigecycline (8%). Among the isolates, 67% (1265) were MDR strains. Of these, 22%, 32% and 16% were resistant to all six, five and four classes of the tested antibiotics. Conclusion: The study found that the frequency of isolation of MDR A. baumannii isolates in the northern region of Oman is high.

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Prevalence and Antimicrobial Susceptibility Pattern of Acinetobacter baumannii Complex in Clinical Samples Among Patients at a Tertiary Care Hospital, Jaipur

ACHARYA,

MAMORIA,

KUMAWAT

et al. 2024

AnnalsARSciMed

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Aims and objectives: Acinetobacter causes a wide spectrum of infections, including nosocomial pneumonia, secondary meningitis, surgical wound infections, skin and soft tissue infections, urinary tract infections, bacteraemia, and transmission via the hands of hospital personnel. The study aimed to determine the prevalence of Acinetobacter baumannii complex isolates and the antimicrobial susceptibility pattern of isolated A. baumannii complex. in clinical samples among patients at Mahatma Gandhi Medical College and Hospital. Introduction: In recent decades, Acinetobacter baumannii (A. baumannii) infections have also occurred outside the ICU or in trauma patients after natural disasters, and they have even affected patients after co-morbidities in the community. Materials and methods: All A. baumannii complex isolates (non-repetitive) from different clinical samples received in a clinical microbiology laboratory from inpatients and outpatients at Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, were included in the study. Routine microscopy of the samples was done. Gram‘s staining was done on all samples except urine. All clinical samples were inoculated on blood agar and MacConkey agar and incubated at 370 °C for 18–24 hours. Antimicrobial susceptibility testing of the isolated A. baumannii complex was done by the VITEK2-AST Compact system. Results: Among 6483 samples, 157 (2.42%) A. baumannii complex isolates were culture-positive, 68.37% were sterile, and 29.19% were other culture-positive. The maximum sensitivity of A. baumannii isolates was seen to be Tigecycline (70%), followed by Minocyclin (29.9%), while maximum resistance was observed for Piperacillin/Toazobactam (97%), followed by Imipenem, Meropenem (96.8%), Ceftazidime (96%), Cefepime (91.7%), Cipropfloxacin (88%), and Gentamycin (87%). Conclusion: Based on this study, it could be concluded that, as antibiotic resistance increases, hardships will be experienced in A. baumannii complex treatment unless the necessary precautions are taken and new antibiotics are discovered. In order to prevent the spreading of resistant Acinetobacter strains, infection control measures should be taken, clinicians and laboratory workers should cooperate during antibiotic use, and hospital hygienic rules should be observed.

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A Prospective Study on Prevalence and Antibiotic Susceptibility Pattern of Acinetobacter baumannii in Clinical Samples obtained from Patients admitted in Various Wards and Intensive Care Units

Cited by 3 publications

References 25 publications

Prevalence and Antibiotic Susceptibility of Acinetobacterin a Tertiary Care Hospital in Chennai, India

Prevalence and Antibiotic Susceptibility of Acinetobacterin a Tertiary Care Hospital in Chennai, India

Antibiotic Resistance Pattern of Acinetobacter baumannii Strains

Prevalence and Antimicrobial Susceptibility Pattern of Acinetobacter baumannii Complex in Clinical Samples Among Patients at a Tertiary Care Hospital, Jaipur

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