A Prospective Study on the Comparison of Efficacy, Quality of Life and Medication Adherence of Triazoles and Allylamines Among Patients With Superficial Mycotic Infections of Skin and Nails in a Tertiary Care Hospital

Abstract

Objective : The main objective of the study was to compare the efficacy, quality of life and medication adherence of Triazoles and Allylamines among patients with superficial fungal infections of skin and nails. Methods: Efficacy was assessed by efficacy parameters such as KOH test and changes in signs and symptom severity score, Quality of life by Dermatology Life Quality Index and Medication Adherence by Medication adherence scale 8. Results : The data collected reveals that greater proportion of patients showed excellent improvement and better quality of life with Allylamines than Triazoles and medication adherence evaluated suggests that both Triazoles and Allylamines have medium adherence. Conclusion: Allylamines are the best choice of antifungal therapy with excellent efficacy, better quality of life and good adherence when compared to Triazoles. Conventional azole antifungals have been associated with high rates of disease recurrence caused in part by lack of adherence to therapy, which points out that, once-daily dosing may a valuable option for physicians treating topical fungal infections. The major drawback of antifungal regimen is its long term therapy leading to poor compliance and a high relapse rate which necessitates such a study.