A Proximity Ligation Screen Identifies Snat2 as a Novel Target of the March1 E3 Ubiquitin Ligase
Renaud Balthazard,
William Mitchell,
Maxime Raymond
et al.
Abstract:E3 ubiquitin ligases are part of various families of proteins and include hundreds of members, which play key roles in all aspects of cell biology. They generally regulate the half-life of other proteins but can also modulate their cellular localization and functions. The MARCH family of ubiquitin ligases is composed of 11 members and two closely related proteins, MARCH1 and MARCH8, share similar targets, while being active in different cell types. Although they appear to target principally immune cell compone… Show more
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