A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats

Li, Diancheng; Zhu, Jiaan; Liu, Fang; Li, Bing; Liu, Feifei; Li, Wenxue

doi:10.21037/atm-19-4534

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Additionally, previous studies that used SWE to evaluate nerve entrapment or DPN reported that the technique could detect an increase in nerve stiffness. In addition, nerve stiffness measured using SWE could better diagnose DPN than cross-sectional area (CSA) [ 9 10 ]. However, the clinical value of SWE in the early detection of DPN remains debatable.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Nerve Viscosity Using Shear Wave Dispersion Imaging in Diabetic Rats: A Novel Technique for Evaluating Diabetic Neuropathy

Liu

Xin

et al. 2022

Korean J Radiol

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Objective Viscoelasticity is an essential feature of nerves, although little is known about their viscous properties. The discovery of shear wave dispersion (SWD) imaging has presented a new approach for the non-invasive evaluation of tissue viscosity. The present study investigated the feasibility of using SWD imaging to evaluate diabetic neuropathy using the sciatic nerve in a diabetic rat model. Materials and Methods This study included 11 diabetic rats in the diabetic group and 12 healthy rats in the control group. Bilateral sciatic nerves were evaluated 3 months after treatment with streptozotocin. We measured the nerve cross-sectional area (CSA), nerve stiffness using shear wave elastography (SWE), and nerve viscosity using SWD imaging. The motor nerve conduction velocity (MNCV) was also measured. These four indicators and the histology of the sciatic nerves were then compared between the two groups. The performance of CSA, SWE, and SWD imaging in distinguishing the two groups was assessed using receiver operating characteristic (ROC) analysis. Results Nerve CSA, stiffness, and viscosity in the diabetic group was significantly higher than those in the control group (all p < 0.05). The results also revealed a significantly lower MNCV in the diabetic group ( p = 0.005). Additionally, the density of myelinated fibers was significantly lower in the diabetic group ( p = 0.004). The average thickness of the myelin sheath was also lower in the diabetic group ( p = 0.012). The area under the ROC curve for distinguishing the diabetic neuropathy group from the control group was 0.876 for SWD imaging, which was significantly greater than 0.677 for CSA ( p = 0.030) and 0.705 for SWE ( p = 0.035). Conclusion Sciatic nerve viscosity measured using SWD imaging was significantly higher in diabetic rats. The viscosity measured using SWD imaging performed well in distinguishing the diabetic neuropathy group from the control group. Therefore, SWD imaging may be a promising method for the evaluation of diabetic neuropathy.

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Section: Introductionmentioning

confidence: 99%

Quantification of Nerve Viscosity Using Shear Wave Dispersion Imaging in Diabetic Rats: A Novel Technique for Evaluating Diabetic Neuropathy

Liu

Xin

et al. 2022

Korean J Radiol

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“…All of these will seriously endanger patients’ physical and psychological health and life safety. [ 16 , 17 ] There is no specific treatment clinically since the etiology and pathogenesis are unclear. At present, based on normal blood glucose, drugs can reverse neuropathy are often used for treatment, such as alprostadil, mecobalamin, and so on.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy

Mai

Wei

Lin³

et al. 2021

Medicine

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Background: Diabetic peripheral neuropathy is a common complication of diabetes and the main cause of disability. At present, there is no specific therapeutic regimen. Mecobalamin is often used as a neurotrophic drug, and its long-term effects are not satisfactory when used alone. Clinical practice indicates that traditional Chinese medicine injection with mecobalamin has a therapeutic advantage in treating diabetic peripheral neuropathy while it lacks evidence-based medicine. In this scheme, the efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy has been studied. Methods: Computers were used to search the English database (PubMed, the Cochrane Library, Embase, Web of Science), and Chinese database (CNKI, Wanfang, CBMDISC, VIP). Besides, manual searching was conducted to search for Baidu Scholar, CHICTR, Google Scholar. During the establishment of the database to November 2020, a randomized controlled trial on traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy was conducted. There were 2 researchers independently conducting data extraction and quality evaluation of literature on the included studies, RevMan5.3 was performed for meta-analysis on the included literature. Results: In this study, the efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy was evaluated by the total effective rate, motor nerve conduction velocity, sensory nerve conduction velocity, adverse reactions, and glucose metabolism level. Conclusion: This study can provide an evidence-based basis on the clinical applications of traditional Chinese medicine injection with mecobalamin in the treatment of diabetic peripheral neuropathy. Ethics and dissemination: The study does not involve patient privacy or rights and does not require approval from an ethics committee. The results may be published in peer-reviewed journals or disseminated at relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/KPW5E.

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Unresolved issues of using ultrasound elastography methods in patients with mononeuropathy of the lower limb girdle and free part of the lower limb

Yurkovskiy,

Pismennikova

2024

jour

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Objective. Systematization of data and analysis of the diagnostic effectiveness of ultrasound elastography for mononeuropathies of the lower limb girdle and free part of the lower limb.Materials and methods. Publications in the PubMed, EMBASE and Web of Science systems were analysed thoroughly, describing cases of the use of imaging methods in patients with mononeuropathy of the lower limb girdle and free part of the lower limb.Results. The most promising for implementation in wide clinical practice ultrasound elastography techniques have been identified. The use of them can, if refined, provide early diagnosis of mononeuropathies of the lower limb girdle and the free part of the lower limb.Conclusion. The use of ultrasound elastography for the diagnosis of mononeuropathy of the lower limb girdle and free part of the lower limb is hampered by the lack of clear ideas regarding the reference values of stiffness indices (kPa, m/s) for specific peripheral nerves and the possible influence of artifacts from bones and other adjacent tissues on these stiffness indices. In addition, there is no clear algorithm for choosing an ultrasound elastography technique, depending on the location and cross-section of the nerve. Solving these issues will allow optimizing the use of ultrasound elastography for the diagnosis of mononeuropathies of the lower limb girdle and the free part of the lower limb.

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A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats

Cited by 3 publications

References 36 publications

Quantification of Nerve Viscosity Using Shear Wave Dispersion Imaging in Diabetic Rats: A Novel Technique for Evaluating Diabetic Neuropathy

Quantification of Nerve Viscosity Using Shear Wave Dispersion Imaging in Diabetic Rats: A Novel Technique for Evaluating Diabetic Neuropathy

Efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy

Unresolved issues of using ultrasound elastography methods in patients with mononeuropathy of the lower limb girdle and free part of the lower limb

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