A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction

Mu, Jin; Yang, Yongyi; Niu, Xiaofeng; Marin, Thibault; Brankov, Jovan G.; Feng, Bing; Pretorius, P. Hendrik; King, Michael A.; Wernick, Miles N.

doi:10.1088/0031-9155/54/18/019

Cited by 25 publications

(43 citation statements)

References 30 publications

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“…The FBP without AC plus lowpass filtering is currently the standard as per ASNC guidelines, 32 while the additional temporal filtering is the standard employed clinically at UMass Medical School. 22,23 This method is referred to as "ST121. "…”

Section: Iid1 Clinical Spatiotemporal Methodsmentioning

confidence: 99%

“…Based on previous reports that imaging dose can be halved using advanced 3D reconstruction 9,10 and that 4D reconstruction can achieve superior performance over 3D reconstruction, 22,23 we hypothesize that advanced 4D reconstruction can yield images at even lower (e.g., quarter) dose with comparable or even better quality to clinically reconstructed images at standard dose. To test our hypothesis, we used Monte Carlo simulation 24 to simulate GSPECT acquisition of different dose levels (standard, half, and quarter dose) with the 4D NURBS-based cardiac-torso (NCAT) phantom 25 and 99m Tc-Sestamibi as the imaging agent.…”

Section: Introductionmentioning

confidence: 90%

“…In recent years, 4D reconstruction methods that exploit the temporal correlation among the gated frames have been developed to improve image quality in GSPECT, aiming to achieve better perfusion defect detectability and functional assessment. [17][18][19][20][21][22][23] Indeed, in our recent work, 23 it was demonstrated that use of temporal processing in GSPECT reconstruction can have greater impact on the accuracy of the myocardium than correction of other degrading factors. However, all these 4D studies were conducted at the standard dose level with the focus on image quality improvement.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous work, 22 attenuation and scatter compensation as well as resolution recovery were integrated with motion-compensated temporal smoothing in 4D reconstruction. Based on previous reports that imaging dose can be halved using advanced 3D reconstruction 9,10 and that 4D reconstruction can achieve superior performance over 3D reconstruction, 22,23 we hypothesize that advanced 4D reconstruction can yield images at even lower (e.g., quarter) dose with comparable or even better quality to clinically reconstructed images at standard dose.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, as preliminary demonstration, GSPECT data acquired in list-mode from two patients were used to mimic lower dose acquisitions for comparison of image quality. It is noted that the previous studies 22, 23 focused on 4D reconstruction development and the effects of different degrading factors at standard dose. The purpose of this work is to investigate the important question of whether 4D reconstruction can be utilized to significantly lower the imaging dose of GSPECT.…”

Section: Introductionmentioning

confidence: 99%

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4D reconstruction for low-dose cardiac gated SPECT

Niu

et al. 2013

Med. Phys.

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Purpose: Due to the combination of high-frequency use and relatively high diagnostic radiation dose (>9 mSv for one scan), there is a need to lower the radiation dose used in myocardial perfusion imaging (MPI) studies in cardiac gated single photon emission computed tomography (GSPECT) in order to reduce its population based cancer risk. The aim of this study is to assess quantitatively the potential utility of advanced 4D reconstruction for GSPECT for significantly lowered imaging dose. Methods: For quantitative evaluation, Monte Carlo simulation with the 4D NURBS-based cardiactorso (NCAT) phantom is used for GSPECT imaging at half and quarter count levels in the projections emulating lower injected activity (dose) levels. Both 4D and 3D reconstruction methods are applied at these lowered dose levels, and compared with standard clinical spatiotemporal reconstruction (ST121) at full dose using a number of metrics on the reconstructed images: (1) overall reconstruction accuracy of the myocardium, (2) regional bias-variance analysis of the left ventricle (LV) wall, (3) uniformity of the LV wall, (4) accuracy of the time activity curve (TAC) of the LV wall, and (5) detectability of perfusion defects using channelized Hotelling observer. As a preliminary demonstration, two sets of patient data acquired in list-mode are used to illustrate the conservation of both image quality and LV ejection fraction (LVEF) by 4D reconstruction where only a portion of the acquired counts at each projection angle are used to mimic low-dose acquisitions. Results: Compared to ST121 at standard dose, even at quarter dose 4D achieved better performance on overall reconstruction accuracy of the myocardium (28.7% improvement on relative root mean square error: standard vs 4D quarter p-value < 10 −30 ), regional bias-variance analysis, and similar performance on accuracy of the TAC of the LV wall and detectability of perfusion defects. A slight degradation in uniformity of the LV wall was observed in 4D at quarter dose due to use of scatter correction which increases reconstruction variance. The reconstructed images from simulated and patient data show that 4D at quarter dose is visually comparable to ST121 at standard dose, if not better. Compared to ST121 and 3D, 4D images exhibit less noise artifacts and better definition of the LV wall. The 4D images are also observed to be more consistent between half dose and quarter dose. 4D also yields more consistent LVEF results at different count levels on the patient data. Conclusions: With various quantitative metrics 4D reconstruction is demonstrated to achieve better or comparable performance at quarter dose (∼2.25 mSv, 75% dose reduction) compared to conventional clinical reconstruction at standard dose (∼9 mSv). Preliminary results from two patient datasets also show that 4D at an equivalent quarter dose can achieve better performance than clinical and 3D methods at higher dose levels. Such a significant dose reduction (75%) has not been demonstrated quantitatively in previous studies in GS...

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Section: Iid1 Clinical Spatiotemporal Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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4D reconstruction for low-dose cardiac gated SPECT

Niu

et al. 2013

Med. Phys.

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Image informatics for clinical and preclinical biomedical analysis

Yadav,

Kolekar,

Patil

et al. 2025

Mining Biomedical Text, Images and Visual Features for Information Retrieval

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Comparison study of temporal regularization methods for fully 5D reconstruction of cardiac gated dynamic SPECT

Niu¹,

Yang²,

King³

2012

Phys. Med. Biol.

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Temporal regularization plays a critical role in cardiac gated dynamic SPECT reconstruction, of which the goal is to obtain an image sequence from a single acquisition which shows simultaneously both cardiac motion and tracer distribution change over the course of imaging (termed 5D). In our recent work, we explored two different approaches for temporal regularization of the dynamic activities in gated dynamic reconstruction without the use of fast camera rotation: one is the dynamic EM (dEM) approach which is imposed on the temporal trend of the time activity of each voxel, and the other is a B-spline modeling approach in which the time activity is regulated by a set of B-spline basis functions. In this work, we extend the B-spline approach to fully 5D reconstruction, and conduct a thorough quantitative comparison with the dEM approach. In evaluation of the reconstruction results, we apply a number of quantitative measures on two major aspects of the reconstructed dynamic images: 1) accuracy of the reconstructed activity distribution in the myocardium, and 2) ability of the reconstructed dynamic activities to differentiate perfusion defects from normal myocardial wall uptake. These measures include: mean square error (MSE), bias-variance analysis (BV), accuracy of time activity curves (TAC), contrast- to-noise ratio (CNR) of a defect, composite kinetic map of the LV wall, and perfusion defect detectability with channelized Hotelling observer (CHO). In the experiments, we simulated gated cardiac imaging with the NURBS-based cardiac-torso (NCAT) phantom and Tc99m-Teboroxime as the imaging agent, where acquisition with the equivalent of only three full camera rotations was used during the imaging period. The results show that both dEM and B-spline 5D could achieve similar overall accuracy in the myocardium in terms of MSE. However, compared to dEM 5D, the B-spline approach could achieve a more accurate reconstruction of the voxel time-activity curves; in particular, B-spline 5D could achieve a much smaller bias level in the early uptake stage of the imaging period. Furthermore, it could allow better separation of the perfusion defect from the normal at both the early and late stages of the imaging period.

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A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction

Cited by 25 publications

References 30 publications

4D reconstruction for low-dose cardiac gated SPECT

4D reconstruction for low-dose cardiac gated SPECT

Image informatics for clinical and preclinical biomedical analysis

Comparison study of temporal regularization methods for fully 5D reconstruction of cardiac gated dynamic SPECT

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