A quantitative trait locus on chromosome 1 modulates intermale aggression in mice

Delprato, Anna; Bonheur, B.; Algéo, Marie-Paule; Murillo, Andrea; Dhawan, Esha; Lu, Lu; Williams, Robert W.; Crusio, Wim E.

doi:10.1111/gbb.12469

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…High impulsivity was found in 5-HT 2B mutant ( Htr2b −/− ) mice [ 161 ]. Among the QTLs underlying behaviors associated with intermale aggression in mice, the strongest candidate within the narrow QTL interval on chromosome 1 for both attack and latency variables is Htr2b gene [ 162 ].…”

Section: The 5-ht 2 Receptor Familymentioning

confidence: 99%

The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

Попова

Цыбко

Науменко

2022

IJMS

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Being different multifactorial forms of psychopathology, aggression, depression and suicidal behavior, which is considered to be violent aggression directed against the self, have principal neurobiological links: preclinical and clinical evidence associates depression, aggression and suicidal behavior with dysregulation in central serotonergic (5-HT) neurotransmission. The implication of different types of 5-HT receptors in the genetic and epigenetic mechanisms of aggression, depression and suicidality has been well recognized. In this review, we consider and compare the orchestra of 5-HT receptors involved in these severe psychopathologies. Specifically, it concentrates on the role of 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3 and 5-HT7 receptors in the mechanisms underlying the predisposition to aggression, depression and suicidal behavior. The review provides converging lines of evidence that: (1) depression-related 5-HT receptors include those receptors with pro-depressive properties (5-HT2A, 5-HT3 and 5-HT7) as well as those providing an antidepressant effect (5-HT1A, 5-HT1B, 5-HT2C subtypes). (2) Aggression-related 5-HT receptors are identical to depression-related 5-HT receptors with the exception of 5-HT7 receptors. Activation of 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C receptors attenuate aggressiveness, whereas agonists of 5-HT3 intensify aggressive behavior.

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Section: The 5-ht 2 Receptor Familymentioning

confidence: 99%

The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

Попова

Цыбко

Науменко

2022

IJMS

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“…We selected these populations to represent a range of relatedness and population structure. The populations were as follows: a reciprocal backcross ( Reifsnyder et al 2000 ), an F2 intercross ( Tyler et al 2016 ), a panel of BXD RILs ( Delprato et al 2015 , 2017 , 2018 ), a cohort of Diversity Outbred mice ( Svenson et al 2012 ; Tyler et al 2017 ), and a cohort from an AIL ( Hernandez Cordero et al 2018 ). We created a sixth study population by averaging over genomic replicates in the RIL.…”

Section: Methodsmentioning

confidence: 99%

“…The data we analyzed were from an experiment investigating the genetics of hippocampal anatomy and spatial learning ( Delprato et al 2015 , 2017 , 2018 ). The data set is called Crusio1.…”

Section: Methodsmentioning

confidence: 99%

Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations

Tyler

Kassaby

Kolishovski

et al. 2021

G3 Genes|Genomes|Genetics

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It is well understood that variation in relatedness among individuals, or kinship, can lead to false genetic associations. Multiple methods have been developed to adjust for kinship while maintaining power to detect true associations. However, relatively unstudied are the effects of kinship on genetic interaction test statistics. Here, we performed a survey of kinship effects on studies of six commonly used mouse populations. We measured inflation of main effect test statistics, genetic interaction test statistics, and interaction test statistics reparametrized by the Combined Analysis of Pleiotropy and Epistasis (CAPE). We also performed linear mixed model (LMM) kinship corrections using two types of kinship matrix: an overall kinship matrix calculated from the full set of genotyped markers, and a reduced kinship matrix, which left out markers on the chromosome(s) being tested. We found that test statistic inflation varied across populations and was driven largely by linkage disequilibrium. In contrast, there was no observable inflation in the genetic interaction test statistics. CAPE statistics were inflated at a level in between that of the main effects and the interaction effects. The overall kinship matrix overcorrected the inflation of main effect statistics relative to the reduced kinship matrix. The two types of kinship matrices had similar effects on the interaction statistics and CAPE statistics, although the overall kinship matrix trended toward a more severe correction. In conclusion, we recommend using an LMM kinship correction for both main effects and genetic interactions and further recommend that the kinship matrix be calculated from a reduced set of markers in which the chromosomes being tested are omitted from the calculation. This is particularly important in populations with substantial population structure, such as recombinant inbred lines in which genomic replicates are used.

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“…Genetic predisposition to aggressive behavior and its neurobiological factors are successfully studied by modern foreign experts (Bortolato et al, 2011;Delprato et al, 2018). Like most biological factors, hormones do not act independently of the social context, which has a significant impact on the manifestation of aggressiveness.…”

Section: Neuropsychological Approach To Aggressiveness Of Personality: Domestic and Foreign Experiencementioning

confidence: 99%

Neuropsychological Approach to the Problem of Aggressive Manifestations of Personality

Chukhrii

Zaplatynska

Komar

et al. 2021

BRAIN

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The article presents a neuropsychological analysis of aggressive manifestations of normal personality and aggression of persons with brain dysfunction. Theoretical analysis of foreign and domestic works on neuropsychological correction of aggressive behavior is carried out. The neuropsychological program on correctional and prophylactic work for persons with affective-personal disorders is offered, considering the peculiarities of determination of aggressive manifestations of personality. The essence of the concept of "aggression" is specified. The types and functions of aggression of personality of different nature are considered: positive, ambivalent, negative. The neuropsychological causes of aggression in connection with the conditionality of aggression by situational and individual and psychological personal factors according to the scheme "personality - aggressive reaction - situation - neuropsychological factor" are clarified. The multifactorial (combination of neuropsychological and social conditions of a formation of aggression) genesis of aggressive behavior in personality disorders, the basis of which is the destructive level of anxiety, which originates from childhood, is analyzed. The integration of neuropsychological and socio-psychological approaches to the study of the problem of aggression is presented.

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A quantitative trait locus on chromosome 1 modulates intermale aggression in mice

Cited by 7 publications

References 40 publications

The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations

Neuropsychological Approach to the Problem of Aggressive Manifestations of Personality

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