Abstract:N-nitrosamine contaminants in medicinal products are of concern due to their high carcinogenic potency; however, not all nitrosamines are created equal, and some are relatively benign chemicals. Understanding the structure-activity relationships (SARs) that drive hazard in one molecule versus another is key to both protecting human health and alleviating costly and sometimes inaccurate animal testing. Here, we report on an extension of the CADRE (Computer-Aided Discovery and REdesign) platform, used broadly by… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.