A quaternized chitin derivatives, egg white protein and montmorillonite composite sponge with antibacterial and hemostatic effect for promoting wound healing

Yang, Yiwen; Zhang, Hao; Zeng, Fanwei; Jia, Qiaoqiao; Zhang, Lina; Yu, Aixi; Duan, Bo

doi:10.1016/j.compositesb.2022.109661

Cited by 43 publications

(15 citation statements)

References 57 publications

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“…[42,43] On a different note, quaternary ammonium moieties are wellknown for their antibacterial activity via membrane disruption and depolarization. [44,45] To enhance the broad-spectrum antimicrobial efficacy of quaternary ammonium moieties, our group has recently developed a strategy to disperse ionic silver in a molecularly dispersed fashion by exploiting the unique interaction between the two to form a molecular complex-like structure. [46] This strategy of accumulating ionic silver at the surface was demonstrated with a polydopamine coating over oxide supports like magnetite and silica glass.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Mude

Tata

Trinath

et al. 2023

Advanced Therapeutics

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The rapid emergence of antimicrobial resistance warrants an antibiotic‐free approach to counter the bacterial threat in all possible applications of environmental and biomedical domains. In the context of smart wound dressing, besides imparting anti‐infective characteristics in a nonconventional fashion, it is also essential to imbibe multifunctional attributes like excessive biofluid drainage, easy‐to‐peel, optimal gas permeation, etc., for which appropriate material design is a prime requisite. In this work, poly(ε‐caprolactone) (PCL)− an FDA approved biocompatible polyester− is chosen for imparting antimicrobial properties by surface derivatization with molecularly‐dispersed ionic silver over quaternary ammonium moieties through a facile room temperate and organic solvent‐free approach. To render the other characteristics mentioned above, two different systems comprising PCL with varying porosity, namely, electrospun fibers and polyester‐coated cotton gauze, are developed. The dressing materials are thoroughly characterized and assessed for their structural, surface chemical, morphological, wettability, antibacterial, and peel strength properties as a function of surface derivatization steps. The bactericidal performance of the quaternary ammonium‐functionalized surfaces has enhanced manifold (≈7–10) after derivatizing with ionic silver. The in vivo efficacy study employing the dressing materials reveals ionic silver derivatized electrospun fibers as the most promising candidate, followed by cotton gauze‐coated with 5% PCL.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Mude

Tata

Trinath

et al. 2023

Advanced Therapeutics

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“…Meanwhile, the polysaccharide chain of CMS contains a large number of hydrophilic groups, and the O-H and -COOH groups could enhance the attraction to water molecules ( Yusof et al, 2018 ). Proper infiltration of water and gas could accelerate wound healing while promoting blood absorption in the wound dressing ( Yang Y. et al, 2022 ). There was no significant difference in WVTR among various sponges as WVTR is mainly related to porosity ( Figure 3E ).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial quaternary ammonium chitosan/carboxymethyl starch/alginate sponges with enhanced hemostatic property for the prevention of dry socket

Deng

Wang

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Tooth extraction commonly leads to postoperative wound bleeding, bacterial infection, and even the occurrence of dry socket. Therefore, developing a biomedical material with favorable antibacterial and excellent hemostatic properties to prevent the post-extraction dry socket is necessary. Herein, quaternary ammonium chitosan/ carboxymethyl starch/alginate (ACQ) sponges are developed via Ca2+ cross-linking, electrostatic interaction, and lyophilization methods. The results show that the bio-multifunctional sponges exhibit interconnected porous structures with significant fluid absorption rates and suitable water vapor transmission rates. In vitro cellular and hemolysis experiments indicate that the developed sponges have acceptable biocompatibility. Notably, the constructed sponges effectively inhibit the growth of E. coli, S. aureus, and C. albicans, as well as achieve rapid hemostasis in the mouse liver injury and mini-pig tooth extraction models by absorbing blood and promoting red blood cell adhesion. Thus, the created bio-multifunctional sponges show tremendous promise as a hemostatic material for wound management after tooth extraction.

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“…Hydrogels and dry biomaterials have demonstrated enormous potential in wound control by facilitating the first stage of the wound healing process, i.e., hemostasis. Wound dressings have also accelerated subsequent stages of wound healing (i.e., inflammation, proliferation, and remodeling) due to their intrinsic wound healing promoting effects and capacity to load various drugs . Hemostatic materials and smart hemostatic devices are rapidly being developed to address various clinical needs such as cardiac, arterial, and gastrointestinal hemorrhage. , Blood coagulation during implantation of indwelling needles and bleeding after their withdrawal are the main problems with the current needles.…”

Section: Potential For Clinical Translationmentioning

confidence: 99%

Engineered Hemostatic Biomaterials for Sealing Wounds

et al. 2022

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Hemostatic biomaterials show great promise in wound control for the treatment of uncontrolled bleeding associated with damaged tissues, traumatic wounds, and surgical incisions. A surge of interest has been directed at boosting hemostatic properties of bioactive materials via mechanisms triggering the coagulation cascade. A wide variety of biocompatible and biodegradable materials has been applied to the design of hemostatic platforms for rapid blood coagulation. Recent trends in the design of hemostatic agents emphasize chemical conjugation of charged moieties to biomacromolecules, physical incorporation of blood-coagulating agents in biomaterials systems, and superabsorbing materials in either dry (foams) or wet (hydrogel) states. In addition, tough bioadhesives are emerging for efficient and physical sealing of incisions. In this Review, we highlight the biomacromolecular design approaches adopted to develop hemostatic bioactive materials. We discuss the mechanistic pathways of hemostasis along with the current standard experimental procedures for characterization of the hemostasis efficacy. Finally, we discuss the potential for clinical translation of hemostatic technologies, future trends, and research opportunities for the development of next-generation surgical materials with hemostatic properties for wound management.

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A quaternized chitin derivatives, egg white protein and montmorillonite composite sponge with antibacterial and hemostatic effect for promoting wound healing

Cited by 43 publications

References 57 publications

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Antibacterial quaternary ammonium chitosan/carboxymethyl starch/alginate sponges with enhanced hemostatic property for the prevention of dry socket

Engineered Hemostatic Biomaterials for Sealing Wounds

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